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Genetics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer&apos;s disease","volume":"41","author":"JC Lambert","year":"2009","journal-title":"Nature Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer&apos;s disease","volume":"43","author":"AC Naj","year":"2011","journal-title":"Nature Genetics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-wide analysis of genetic loci associated with Alzheimer disease","volume":"303","author":"S Seshadri","year":"2010","journal-title":"JAMA: the journal of the American Medical Association"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer&apos;s disease","volume":"45","author":"JC Lambert","year":"2013","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1042\/BST0390910","article-title":"Alzheimer&apos;s disease genetics: lessons to improve disease modelling","volume":"39","author":"RJ Guerreiro","year":"2011","journal-title":"Biochemical Society transactions"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000103512","article-title":"Non-replication and inconsistency in the genome-wide association setting","volume":"64","author":"JP Ioannidis","year":"2007","journal-title":"Human heredity"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1086\/423901","article-title":"The future of association studies: gene-based analysis and replication","volume":"75","author":"BM Neale","year":"2004","journal-title":"American journal of human genetics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000101424","article-title":"Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation","volume":"64","author":"V Moskvina","year":"2007","journal-title":"Human heredity"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/sj.ejhg.5201583","article-title":"An utter refutation of the &quot;fundamental theorem of the HapMap&quot;","volume":"14","author":"JD Terwilliger","year":"2006","journal-title":"European journal of human genetics: EJHG"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-7-3","article-title":"Both common variations and rare non-synonymous substitutions and small insertion\/deletions in CLU are associated with increased Alzheimer risk","volume":"7","author":"K Bettens","year":"2012","journal-title":"Molecular neurodegeneration"},{"key":"ref16","first-page":"222","article-title":"Linkage strategies for genetically complex traits. I. Multilocus models","volume":"46","author":"N Risch","year":"1990","journal-title":"American journal of human genetics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1086\/376549","article-title":"Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia","volume":"73","author":"CM Lewis","year":"2003","journal-title":"American journal of human genetics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/376547","article-title":"Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder","volume":"73","author":"R Segurado","year":"2003","journal-title":"American journal of human genetics"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Lambert JCea (2013) Extended meta-analysis of 74,538 individuals identifies 11 new susceptibility loci for Alzheimer&apos;s disease.","DOI":"10.1016\/j.jalz.2013.04.040"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","article-title":"SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap","volume":"24","author":"AD Johnson","year":"2008","journal-title":"Bioinformatics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","article-title":"Genetic Control of Human Brain Transcript Expression in Alzheimer Disease","volume":"84","author":"JA Webster","year":"2009","journal-title":"American Journal of Human Genetics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1471-4159.2011.07432.x","article-title":"Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies","volume":"119","author":"D Trabzuni","year":"2011","journal-title":"J Neurochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1038\/onc.2011.25","article-title":"TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression","volume":"30","author":"M Seux","year":"2011","journal-title":"Oncogene"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/cdd.2012.30","article-title":"TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death","volume":"19","author":"M Seillier","year":"2012","journal-title":"Cell death and differentiation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/pros.22477","article-title":"TP53INP1 as new therapeutic target in castration-resistant prostate cancer","volume":"72","author":"S Giusiano","year":"2012","journal-title":"Prostate"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, <etal>et al<\/etal>.. (2012) Inverse association between cancer and Alzheimer&apos;s disease: results from the Framingham Heart Study. British Medical Journal 344.","DOI":"10.1136\/bmj.e1442"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1212\/WNL.0b013e3181c91873","article-title":"Cancer linked to Alzheimer disease but not vascular dementia","volume":"74","author":"CM Roe","year":"2010","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/gene.2012.12","article-title":"The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease","volume":"13","author":"CT Watson","year":"2012","journal-title":"Genes and immunity"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, <etal>et al<\/etal>.. (2013) BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Molecular &amp; cellular proteomics: MCP.","DOI":"10.1074\/mcp.M112.025882"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"23521","DOI":"10.1074\/jbc.M111.220178","article-title":"The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle","volume":"286","author":"HJ Warnatz","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.mam.2012.05.005","article-title":"The mitochondrial transporter family SLC25: identification, properties and physiopathology","volume":"34","author":"F Palmieri","year":"2013","journal-title":"Molecular aspects of medicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1074\/jbc.M111.328377","article-title":"Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway","volume":"287","author":"C Katz","year":"2012","journal-title":"The Journal of biological chemistry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00125-012-2773-0","article-title":"Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology","volume":"56","author":"F Bernhard","year":"2013","journal-title":"Diabetologia"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1111\/j.1464-5491.2012.03665.x","article-title":"The role of obesity-related genetic loci in insulin sensitivity","volume":"29","author":"T Fall","year":"2012","journal-title":"Diabetic medicine: a journal of the British Diabetic Association"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/oby.2009.413","article-title":"Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI\/MRS 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