{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T10:53:19Z","timestamp":1769856799406,"version":"3.49.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0095342","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T20:55:40Z","timestamp":1397595340000},"page":"e95342","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effects of Hypocretin\/Orexin Cell Transplantation on Narcoleptic-Like Sleep Behavior in Rats"],"prefix":"10.1371","volume":"9","author":[{"given":"Oscar","family":"Arias-Carri\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Murillo-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1517\/13543784.16.11.1785","article-title":"The hypocretin\/orexin receptor: therapeutic prospective in sleep disorders","volume":"16","author":"S Nishino","year":"2007","journal-title":"Expert Opin Investig Drugs"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12305","DOI":"10.1523\/JNEUROSCI.2630-12.2012","article-title":"Narcolepsy: neural mechanisms of sleepiness and cataplexy","volume":"32","author":"CR Burgess","year":"2012","journal-title":"J Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/187152709788921681","article-title":"Cell transplantation: a future therapy for narcolepsy?","volume":"8","author":"O Arias-Carrion","year":"2009","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"ref4","unstructured":"Arias-Carrion O (2009) Hypocretin system and narcolepsy. Rev Med Chil. 2009\/12\/17 ed. pp. 1209\u20131216."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"L de Lecea","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"T Sakurai","year":"1998","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"RM Chemelli","year":"1999","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1212\/01.WNL.0000168173.71940.ab","article-title":"Concomitant loss of dynorphin, NARP, and orexin in narcolepsy","volume":"65","author":"A Crocker","year":"2005","journal-title":"Neurology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity","volume":"30","author":"J Hara","year":"2001","journal-title":"Neuron"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1073\/pnas.0400590101","article-title":"Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice","volume":"101","author":"M Mieda","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1001\/archneur.59.10.1553","article-title":"The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias","volume":"59","author":"E Mignot","year":"2002","journal-title":"Arch Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"C Peyron","year":"2000","journal-title":"Nat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0896-6273(00)00058-1","article-title":"Reduced number of hypocretin neurons in human narcolepsy","volume":"27","author":"TC Thannickal","year":"2000","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1073\/pnas.0400590101","article-title":"Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice","volume":"101","author":"M Mieda","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref15","first-page":"23","article-title":"Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs","volume":"3","author":"J John","year":"2000","journal-title":"Sleep Research Online"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/sleep\/26.8.953","article-title":"Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog","volume":"6","author":"N Fujiki","year":"2003","journal-title":"Sleep"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/sleep\/28.6.754","article-title":"Emerging therapies in narcolepsy-cataplexy","volume":"28","author":"E Mignot","year":"2005","journal-title":"Sleep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0031-9384(04)00349-X","article-title":"Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man","volume":"83","author":"M Hallschmid","year":"2004","journal-title":"Physiology & Behavior"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Dhuria SV, Hanson LR, Frey II WH (2008) Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system. Journal of Pharmaceutical Sciences ahead of print.","DOI":"10.1002\/jps.21604"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1755-7682-1-17","article-title":"Locally induced neural stem cells\/pluripotent stem cells for in vivo cell replacement therapy","volume":"1","author":"T-F Yuan","year":"2008","journal-title":"International Archives of Medicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1460-9568.2008.06446.x","article-title":"Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice","volume":"28","author":"M Liu","year":"2008","journal-title":"European Journal of Neuroscience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1523\/JNEUROSCI.6069-10.2011","article-title":"Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice","volume":"31","author":"M Liu","year":"2011","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2006.05.017","article-title":"Survival rates through time of hypocretin grafted neurons within their projection site","volume":"404","author":"O Arias-Carrion","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1093\/sleep\/27.8.1465","article-title":"Transplantation of hypocretin neurons into the pontine reticular formation: preliminary results","volume":"27","author":"O Arias-Carrion","year":"2004","journal-title":"Sleep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/WCO.0b013e3282f22ad9","article-title":"Therapies for narcolepsy with or without cataplexy: evidence-based review","volume":"20","author":"S Keam","year":"2007","journal-title":"Curr Opin Neurol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0306-4522(02)00575-4","article-title":"Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats","volume":"116","author":"D Gerashchenko","year":"2003","journal-title":"Neuroscience"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7273","DOI":"10.1523\/JNEUROSCI.21-18-07273.2001","article-title":"Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat","volume":"21","author":"D Gerashchenko","year":"2001","journal-title":"J Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0014-4886(03)00388-1","article-title":"Relationship between CSF hypocretin levels and hypocretin neuronal loss","volume":"184","author":"D Gerashchenko","year":"2003","journal-title":"Exp Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/sleep\/26.8.943","article-title":"Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study","volume":"26","author":"E Murillo-Rodriguez","year":"2003","journal-title":"Sleep"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2007.01.076","article-title":"Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat","volume":"562","author":"E Murillo-Rodriguez","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/sleep\/28.6.754","article-title":"Emerging therapies in narcolepsy-cataplexy","volume":"28","author":"E Mignot","year":"2005","journal-title":"Sleep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.psych.55.090902.141545","article-title":"Hypocretin (orexin): role in normal behavior and neuropathology","volume":"55","author":"JM Siegel","year":"2004","journal-title":"Annu Rev Psychol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/jnr.22666","article-title":"Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors","volume":"89","author":"O Arias-Carrion","year":"2011","journal-title":"J Neurosci Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.sleep.2006.05.009","article-title":"Daytime sleepiness with and without cataplexy in Chinese-Taiwanese patients","volume":"7","author":"YS Huang","year":"2006","journal-title":"Sleep Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/exnr.1996.6386","article-title":"Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery","volume":"144","author":"JH Kordower","year":"1997","journal-title":"Exp Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1043-6618(03)00037-9","article-title":"Stem cells for cell therapy in Parkinson's disease","volume":"47","author":"O Lindvall","year":"2003","journal-title":"Pharmacol Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jnr.20235","article-title":"Neurogenesis in the subventricular zone following transcranial magnetic field stimulation and nigrostriatal lesions","volume":"78","author":"O Arias-Carrion","year":"2004","journal-title":"J Neurosci Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/jnr.21068","article-title":"Neuronal precursors within the adult rat subventricular zone differentiate into dopaminergic neurons after substantia nigra lesion and chromaffin cell transplant","volume":"84","author":"O Arias-Carrion","year":"2006","journal-title":"J Neurosci Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.sleep.2011.06.015","article-title":"Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy","volume":"12","author":"PC Baier","year":"2011","journal-title":"Sleep Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awn193","article-title":"Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal Orexin A (Hypocretin-1)","volume":"131","author":"PC Baier","year":"2008","journal-title":"Brain"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","article-title":"The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy","volume":"262","author":"SL Weinhold","year":"2014","journal-title":"Behav Brain Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0095342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T15:21:33Z","timestamp":1565364093000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0095342"}},"subtitle":[],"editor":[{"given":"Andreas","family":"Androutsellis-Theotokis","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0095342","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}