{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:42:46Z","timestamp":1780580566451,"version":"3.54.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0095925","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T20:41:08Z","timestamp":1400186468000},"page":"e95925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["eNOS Activation by HDL Is Impaired in Genetic CETP Deficiency"],"prefix":"10.1371","volume":"9","author":[{"given":"Monica","family":"Gomaraschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Ossoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo B.","family":"Cefal\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Averna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Albert","family":"Kuivenhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Kees","family":"Hovingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Veglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calabresi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa064278","article-title":"HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events","volume":"357","author":"PJ Barter","year":"2007","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1056\/NEJMoa031766","article-title":"Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol","volume":"350","author":"ME Brousseau","year":"2004","journal-title":"N Engl J Med"},{"key":"ref3","first-page":"82","article-title":"Safety and tolerability of dalcetrapib","volume":"104","author":"EA Stein","year":"2009","journal-title":"Am J Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ahj.2008.09.022","article-title":"Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients","volume":"157","author":"D Bloomfield","year":"2009","journal-title":"Am Heart J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa0706628","article-title":"Effects of Torcetrapib in Patients at High Risk for Coronary Events","volume":"357","author":"PJ Barter","year":"2007","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1056\/NEJMoa1206797","article-title":"Effects of dalcetrapib in patients with a recent acute coronary syndrome","volume":"367","author":"GG Schwartz","year":"2012","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/eurheartj\/ehr348","article-title":"Torcetrapib impairs endothelial function in hypertension","volume":"33","author":"B Simic","year":"2012","journal-title":"Eur Heart J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/FJC.0b013e3181cf03cb","article-title":"Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition","volume":"55","author":"MA Connelly","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMe0707210","article-title":"Illuminating HDL\u2013is it still a viable therapeutic target","volume":"357","author":"DJ Rader","year":"2007","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/CIRCULATIONAHA.111.066589","article-title":"Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport","volume":"125","author":"RS Rosenson","year":"2012","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1001689","article-title":"Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis","volume":"364","author":"AV Khera","year":"2011","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/01.ATV.0000094961.74697.54","article-title":"Endothelial protection by high-density lipoproteins: from bench to bedside","volume":"23","author":"L Calabresi","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1161\/01.RES.0000225982.01988.93","article-title":"Endothelial and antithrombotic actions of HDL","volume":"98","author":"C Mineo","year":"2006","journal-title":"Circ Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1172\/JCI42946","article-title":"Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease","volume":"121","author":"C Besler","year":"2011","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1161\/01.CIR.0000070934.69310.1A","article-title":"Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein","volume":"107","author":"RJ Bisoendial","year":"2003","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1067\/mhj.2002.123145","article-title":"A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: enhanced vasorelaxation and increased endothelial nitric oxide synthase expression","volume":"144","author":"JT Kuvin","year":"2002","journal-title":"Am Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5551\/jat.11.110","article-title":"Molecular mechanisms of cholesteryl ester transfer protein deficiency in Japanese","volume":"11","author":"M Nagano","year":"2004","journal-title":"J Atheroscler Thromb"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1172\/JCI27602","article-title":"HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway","volume":"116","author":"F Matsuura","year":"2006","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/ATVBAHA.106.138347","article-title":"Inhibition of cholesteryl ester transfer protein by torcetrapib modestly increases macrophage cholesterol efflux to HDL","volume":"27","author":"L Yvan-Charvet","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/ATVBAHA.110.207142","article-title":"Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib","volume":"30","author":"L Yvan-Charvet","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bbalip.2012.12.008","article-title":"Inhibition of cholesteryl ester transfer protein by anacetrapib does not impair the anti-inflammatory properties of high density lipoprotein","volume":"1831","author":"S Han","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.atherosclerosis.2009.01.006","article-title":"A novel homozygous mutation in CETP gene as a cause of CETP deficiency in a caucasian kindred","volume":"205","author":"L Calabresi","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.atherosclerosis.2008.08.031","article-title":"Novel mutations of CETP gene in Italian subjects with hyeralphalipoproteinemia","volume":"204","author":"AB Cefalu","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1194\/jlr.M600405-JLR200","article-title":"Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians","volume":"48","author":"WA van der Steeg","year":"2007","journal-title":"J Lipid Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-2275(20)41577-9","article-title":"A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol","volume":"19","author":"GR Warnick","year":"1978","journal-title":"J Lipid Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/CIRCULATIONAHA.107.705657","article-title":"Normal vascular function despite low levels of high-density lipoprotein cholesterol in carriers of the apolipoprotein A-I(Milano) mutant","volume":"116","author":"M Gomaraschi","year":"2007","journal-title":"Circulation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1161\/01.ATV.18.9.1450","article-title":"Factors influencing the ability of HDL to inhibit expression of vascular cell adhesion molecule-1 in endothelial cells","volume":"18","author":"DT Ashby","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI200418004","article-title":"HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3","volume":"113","author":"JR Nofer","year":"2004","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0022-2275(20)33375-7","article-title":"Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells","volume":"40","author":"PW Baker","year":"1999","journal-title":"J Lipid Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e49336","DOI":"10.1371\/journal.pone.0049336","article-title":"High-Density Lipoprotein (HDL) Particle Subpopulations in Heterozygous Cholesteryl Ester Transfer Protein (CETP) Deficiency: Maintenance of Antioxidative Activity","volume":"7","author":"S Chantepie","year":"2012","journal-title":"PLoS ONE"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.atherosclerosis.2008.07.047","article-title":"Acute hypertriglyceridaemia in humans increases the triglyceride content and decreases the anti-inflammatory capacity of high density lipoproteins","volume":"204","author":"S Patel","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15832","DOI":"10.1074\/jbc.M100228200","article-title":"Apolipoprotein A-II Modulates the Binding and Selective Lipid Uptake of Reconstituted High Density Lipoprotein by Scavenger Receptor BI","volume":"276","author":"MC De Beer","year":"2001","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0021-9150(02)00311-8","article-title":"Scavenger receptor BI (SR-BI) mediates a higher selective cholesteryl ester uptake from LpA-I compared with LpA-I:A-II lipoprotein particles","volume":"166","author":"F Rinninger","year":"2003","journal-title":"Atherosclerosis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.atherosclerosis.2003.08.005","article-title":"Modulation of HDL metabolism by probucol in complete cholesteryl ester transfer protein deficiency","volume":"171","author":"H Noto","year":"2003","journal-title":"Atherosclerosis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0022-3565(24)29198-9","article-title":"Post-translational control of endothelial nitric oxide synthase: why isn't calcium\/calmodulin enough","volume":"299","author":"D Fulton","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/ATVBAHA.109.199166","article-title":"ABCG1 Deficiency in Mice Promotes Endothelial Activation and Monocyte-Endothelial Interactions","volume":"30","author":"AM Whetzel","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1172\/JCI35470","article-title":"ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet","volume":"118","author":"N Terasaka","year":"2008","journal-title":"J Clin Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.atherosclerosis.2011.12.027","article-title":"Functionality of postprandial larger HDL2 particles is enhanced following CETP inhibition therapy","volume":"221","author":"N Bellanger","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.thromres.2008.06.022","article-title":"Cholesterylestertransfer protein inhibition and endothelial function in type II hyperlipidemia","volume":"123","author":"F Hermann","year":"2009","journal-title":"Thromb Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/eurheartj\/ehs019","article-title":"Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial","volume":"33","author":"TF Luscher","year":"2012","journal-title":"Eur Heart J"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0095925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T22:57:21Z","timestamp":1746226641000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0095925"}},"subtitle":[],"editor":[{"given":"Antonio","family":"Moschetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0095925","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}