{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T20:10:35Z","timestamp":1776802235948,"version":"3.51.2"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0096442","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T20:41:42Z","timestamp":1399408902000},"page":"e96442","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Congenitally Acquired Persistent Lymphocytic Choriomeningitis Viral Infection Reduces Neuronal Progenitor Pools in the Adult Hippocampus and Subventricular Zone"],"prefix":"10.1371","volume":"9","author":[{"given":"Tony","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Vasek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"G Kempermann","year":"1997","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1073\/pnas.85.7.2265","article-title":"T-cell tolerance: exposure to virus in utero does not cause a permanent deletion of specific T cells","volume":"85","author":"BD Jamieson","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/35066584","article-title":"Neurogenesis in the adult is involved in the formation of trace memories","volume":"410","author":"TJ Shors","year":"2001","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1053\/j.tcam.2009.07.002","article-title":"Small Animal Zoonoses and Immuncompromised Pet Owners","volume":"24","author":"I Mani","year":"2009","journal-title":"Topics in Companion Animal Medicine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"H van Praag","year":"2002","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1128\/JVI.66.5.3155-3160.1992","article-title":"Viral infection of the thymus","volume":"66","author":"CC King","year":"1992","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF02122450","article-title":"Production or prevention of neurologic disease by continuous lines of arenavirus-specific cytotoxic T lymphocytes","volume":"175","author":"GA Cole","year":"1986","journal-title":"Med Microbiol Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"PS Eriksson","year":"1998","journal-title":"Nat Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/oxfordjournals.bmb.a072515","article-title":"Viral persistence and disease: cytopathology in the absence of cytolysis","volume":"47","author":"JC la Torre de","year":"1991","journal-title":"Br Med Bull"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.spen.2012.02.002","article-title":"Lymphocytic Choriomeningitis Virus: An Underrecognized Cause of Neurologic Disease in the Fetus, Child, and Adult","volume":"19","author":"DJ Bonthius","year":"2012","journal-title":"Seminars in Pediatric Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/321897","article-title":"Congenital Lymphocytic Choriomeningitis Virus Infection: Decade of Rediscovery","volume":"33","author":"LL Barton","year":"2001","journal-title":"CLIN INFECT DIS"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/ana.21161","article-title":"Congenital lymphocytic choriomeningitis virus infection: spectrum of disease","volume":"62","author":"DJ Bonthius","year":"2007","journal-title":"Ann Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1099\/0022-1317-64-8-1689","article-title":"Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains","volume":"64 (Pt 8)","author":"FJ Dutko","year":"1983","journal-title":"J Gen Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9082","DOI":"10.1128\/JVI.00795-06","article-title":"Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus","volume":"80","author":"S Kunz","year":"2006","journal-title":"J Virol"},{"key":"ref15","first-page":"Unit1910","article-title":"Animal models using lymphocytic choriomeningitis virus","volume":"19","author":"M Herrath von","year":"2001","journal-title":"Curr Protoc Immunol Chapter"},{"key":"ref16","unstructured":"LCMV and the central nervous system: uncovering basic principles of CNS physiology and virus-induced disease (2002) LCMV and the central nervous system: uncovering basic principles of CNS physiology and virus-induced disease. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.jeffredwine.com\/CTMI-LCMV%20Evans%202002.PDF\" xlink:type=\"simple\">http:\/\/www.jeffredwine.com\/CTMI-LCMV%20Evans%202002.PDF<\/ext-link>."},{"key":"ref17","first-page":"95","article-title":"Ultrastructural localization of viral antigens in the CNS of mice persistently infected with lymphocytic choriomeningitis virus (LCMV)","volume":"110","author":"M Rodriguez","year":"1983","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1084\/jem.160.2.521","article-title":"Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"R Ahmed","year":"1984","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Ciurea A, Klenerman P, Hunziker L (1999) Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice.","DOI":"10.1073\/pnas.96.21.11964"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jviromet.2007.08.025","article-title":"Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo","volume":"147","author":"MM McCausland","year":"2008","journal-title":"J Virol Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1371\/journal.ppat.0030149","article-title":"Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat","volume":"3","author":"DJ Bonthius","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Mirzadeh Z, Doetsch F, Sawamoto K, Wichterle H, Alvarez-Buylla A (2010) The subventricular zone en-face: wholemount staining and ependymal flow. J Vis Exp. doi:10.3791\/1938.","DOI":"10.3791\/1938"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12031-009-9293-5","article-title":"Interleukin-1 mediates long-term hippocampal dentate granule cell loss following postnatal viral infection","volume":"41","author":"AG Orr","year":"2010","journal-title":"J Mol Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1073\/pnas.0800898105","article-title":"CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis","volume":"105","author":"EE McCandless","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/nbdi.2002.0531","article-title":"Neonatal viral infection decreases neuronal progenitors and impairs adult neurogenesis in the hippocampus","volume":"11","author":"A Sharma","year":"2002","journal-title":"Neurobiol Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1111\/j.1532-5415.2011.03719.x","article-title":"Associations between cytomegalovirus infection and functional impairment and frailty in the BELFRAIL Cohort","volume":"59","author":"C Mathe\u00ef","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1128\/JVI.79.17.11457-11466.2005","article-title":"Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis","volume":"79","author":"RS Klein","year":"2005","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/13550289709029467","article-title":"Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice","volume":"3","author":"MD Brot","year":"1997","journal-title":"J Neurovirol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0304-3940(93)90748-A","article-title":"Neurogenesis persists in the subependymal layer of the adult mouse brain","volume":"149","author":"FS Corotto","year":"1993","journal-title":"Neurosci Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.molmed.2003.12.001","article-title":"Virus-induced neurobehavioral disorders: mechanisms and implications","volume":"10","author":"K Tomonaga","year":"2004","journal-title":"Trends Mol Med"},{"key":"ref31","unstructured":"Colonna L, Zaidi B, Garcia-Verdugo JM, Doetsch F (2008) A specialized vascular niche for adult neural stem cells. Cell Stem Cell."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.stem.2010.05.019","article-title":"Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1\/CXCR4 signaling","volume":"7","author":"E Kokovay","year":"2010","journal-title":"Cell Stem Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/cne.21229","article-title":"Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain","volume":"500","author":"PB Tran","year":"2007","journal-title":"J Comp Neurol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.3390\/v2112443","article-title":"Inhibition of the type I interferon antiviral response during arenavirus infection","volume":"2","author":"P Borrow","year":"2010","journal-title":"Viruses"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e25406","DOI":"10.1371\/journal.pone.0025406","article-title":"Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation","volume":"6","author":"A Turbic","year":"2011","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/jnr.21359","article-title":"Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke","volume":"85","author":"XS Liu","year":"2007","journal-title":"J Neurosci Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/j.yexcr.2008.02.019","article-title":"The beta-chemokines CCL2 and CCL7 are two novel differentiation factors for midbrain dopaminergic precursors and neurons","volume":"314","author":"LC Edman","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.4049\/jimmunol.167.7.4091","article-title":"Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis","volume":"167","author":"MT Liu","year":"2001","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.virol.2004.08.024","article-title":"Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10","volume":"329","author":"G van Marle","year":"2004","journal-title":"Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fphar.2012.00041","article-title":"Microglial activation - tuning and pruning adult neurogenesis","volume":"3","author":"CT Ekdahl","year":"2012","journal-title":"Front Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-2012-120070","article-title":"Aging-related neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice","volume":"30","author":"F Guzman-Sanchez","year":"2012","journal-title":"J Alzheimers Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T02:54:51Z","timestamp":1597805691000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096442"}},"subtitle":[],"editor":[{"given":"Robert Shin","family":"Fujinami","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,6]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096442","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,6]]}}}