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Naito","year":"2006","journal-title":"Gastroenterology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/JCM.01616-06","article-title":"Strategy to characterize the number and type of repeating EPIYA phosphorylation motifs in the carboxyl terminus of CagA protein in <italic>Helicobacter pylori<\/italic> clinical isolates","volume":"45","author":"EG Panayotopoulou","year":"2007","journal-title":"J Clin Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.gastro.2008.03.041","article-title":"Clinical relevance of <italic>Helicobacter pylori<\/italic> cagA and vacA gene polymorphisms","volume":"135","author":"D Basso","year":"2008","journal-title":"Gastroenterology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1523-5378.2009.00684.x","article-title":"Distinct cagA EPIYA motifs are associated with ethnic diversity in Malaysia and Singapore","volume":"14","author":"HM 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Tegtmeyer","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1478-811X-9-28","article-title":"Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by <italic>Helicobacter pylori<\/italic>","volume":"9","author":"S Backert","year":"2011","journal-title":"Cell Commun Signal"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00535-012-0592-1","article-title":"How <italic>Helicobacter pylori<\/italic> infection controls gastric acid secretion","volume":"47","author":"AJ Smolka","year":"2012","journal-title":"J Gastroenterol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1073\/pnas.90.12.5791","article-title":"Molecular characterization of the 128-kDa immunodominant antigen of <italic>Helicobacter pylori<\/italic> associated with cytotoxicity and duodenal ulcer.","volume":"90","author":"A Covacci","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1128\/JCM.36.8.2258-2263.1998","article-title":"Variants of the 3&apos; region of the cagA gene in <italic>Helicobacter pylori<\/italic> isolates from patients with different <italic>H. pylori<\/italic>-associated diseases.","volume":"36","author":"Y Yamaoka","year":"1998","journal-title":"J Clin Microbiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1053\/gast.1999.0029900342","article-title":"Relationship between the <italic>cagA<\/italic> 3&apos; repeat region of <italic>Helicobacter pylori<\/italic>, gastric histology, and susceptibility to low pH.","volume":"117","author":"Y Yamaoka","year":"1999","journal-title":"Gastroenterol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1038\/sj.onc.1203957","article-title":"The protein tyrosine kinase family of the human genome","volume":"19","author":"DR Robinson","year":"2000","journal-title":"Oncogene"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/373536a0","article-title":"Catalytic specificity of protein-tyrosine kinases is critical for selective signaling","volume":"373","year":"1995","journal-title":"Nature"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1478-811X-11-77","article-title":"The functional interplay of <italic>Helicobacter pylori<\/italic> factors with gastric epithelial cells induces a multi-step process in pathogenesis","volume":"11","author":"G Posselt","year":"2013","journal-title":"Cell Commun Signal"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ejcb.2010.11.006","article-title":"Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the <italic>Helicobacter pylori<\/italic> CagA protein","volume":"90","author":"N Tegtmeyer","year":"2011","journal-title":"Eur J Cell Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/41483","article-title":"The complete genome sequence of the gastric pathogen <italic>Helicobacter pylori<\/italic>","volume":"388","author":"JF Tomb","year":"1997","journal-title":"Nature"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1128\/IAI.72.6.3646-3649.2004","article-title":"<italic>Helicobacter pylori<\/italic> induces AGS cell motility and elongation via independent signaling pathways","volume":"72","author":"S Moese","year":"2004","journal-title":"Infect Immun"},{"key":"ref78","first-page":"1148","article-title":"The <italic>Helicobacter pylori<\/italic> CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell","volume":"9","author":"S Moese","year":"2007","journal-title":"Microbiol"},{"key":"ref79","first-page":"798","article-title":"<italic>Helicobacter pylori<\/italic> HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO Rep","volume":"11","author":"B Hoy","year":"2010"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"9300","DOI":"10.1073\/pnas.0409873102","article-title":"NF-kappaB activation and potentiation of proinflammatory responses by the <italic>Helicobacter pylori<\/italic> CagA protein","volume":"102","author":"S Brandt","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/1471-2164-11-335","article-title":"Sequencing, annotation, and comparative genome analysis of the gerbil-adapted <italic>Helicobacter pylori<\/italic> strain B8","volume":"11","author":"M Farnbacher","year":"2010","journal-title":"BMC Genomics"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1128\/JCM.05562-11","article-title":"Association between <italic>Helicobacter pylori<\/italic> virulence factors and gastroduodenal diseases in Okinawa, Japan","volume":"50","author":"O Matsunari","year":"2012","journal-title":"J Clin Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T02:55:03Z","timestamp":1597805703000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096488"}},"subtitle":[],"editor":[{"given":"Ivo G.","family":"Boneca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,6]]},"references-count":82,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096488","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,6]]}}}