{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:58:34Z","timestamp":1768085914264,"version":"3.49.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0096542","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T22:02:59Z","timestamp":1399586579000},"page":"e96542","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Conditions Associated with Circulating Tumor-Associated Folate Receptor 1 Protein in Healthy Men and Women"],"prefix":"10.1371","volume":"9","author":[{"given":"Linda E.","family":"Kelemen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Brenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"C. Whitaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Piskorz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Csizmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula J.","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ijc.21712","article-title":"The role of folate receptor alpha in cancer development, progression and treatment: Cause, consequence or innocent bystander?","volume":"119","author":"LE Kelemen","year":"2006","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.nu.10.070190.001535","article-title":"Folate-binding proteins","volume":"10","author":"GB Henderson","year":"1990","journal-title":"Annu Rev Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ygyno.2013.07.080","article-title":"Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer","volume":"131","author":"CL Walters","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1200\/JCO.2013.49.7685","article-title":"PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer","volume":"31","author":"RW Naumann","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.addr.2004.01.008","article-title":"Folate-targeted chemotherapy","volume":"56","author":"CP Leamon","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nm.2472","article-title":"Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results","volume":"17","author":"GM van Dam","year":"2011","journal-title":"Nat Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/ijc.23717","article-title":"Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligands","volume":"123","author":"W He","year":"2008","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1021\/jm100509v","article-title":"Folate-targeted therapies for cancer","volume":"53","author":"W Xia","year":"2010","journal-title":"J Med Chem"},{"key":"ref9","first-page":"2820","article-title":"Modulation of the folate receptor alpha gene by the estrogen receptor: mechanism and implications in tumor targeting","volume":"63","author":"KM Kelley","year":"2003","journal-title":"Cancer Res"},{"key":"ref10","first-page":"71","article-title":"Folate binding protein and the estrogen receptor in breast cancer","volume":"8","author":"H Rochman","year":"1985","journal-title":"Cancer Detect Prev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1172\/JCI113469","article-title":"Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells","volume":"81","author":"MA Kane","year":"1988","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1073\/pnas.89.13.6006","article-title":"Folate receptor allows cells to grow in low concentrations of 5-methyltetrahydrofolate","volume":"89","author":"H Matsue","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1172\/JCI115959","article-title":"Transfection of a glycosylated phosphatidylinositol-anchored folate-binding protein complementary DNA provides cells with the ability to survive in low folate medium","volume":"90","author":"CA Luhrs","year":"1992","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1158\/0008-5472.CAN-04-2890","article-title":"Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting","volume":"65","author":"T Tran","year":"2005","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-1119(99)00081-5","article-title":"Retinoic acid-dependent upregulation of mouse folate receptor-alpha expression in embryonic stem cells, and conservation of alternative splicing patterns","volume":"230","author":"JA Bolton","year":"1999","journal-title":"Gene"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1158\/1055-9965.EPI-05-0260","article-title":"Multivitamin and alcohol intake and folate receptor alpha expression in ovarian cancer","volume":"14","author":"LE Kelemen","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref17","first-page":"8781","article-title":"Food standards: amendment of the standards of identity for enriched grain products to require addition of folic acid. Final rule. 1996","volume":"61","journal-title":"Fed Regist"},{"key":"ref18","first-page":"3026","article-title":"Health Canada (November 25, 1998) Folic acid fortification in Canada","volume":"(24)","journal-title":"Canada Gazette Part II 132"},{"key":"ref19","unstructured":"Food standards Australia New Zealand. Final assessment report. Proposal P295. Consideration of mandatory fortification with folic acid. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwfoodstandardsgovau\/standardsdevelopment\/\" xlink:type=\"simple\">http:\/\/wwwfoodstandardsgovau\/standardsdevelopment\/<\/ext-link>. Accessed: 2006 October 4."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/aje\/kwh207","article-title":"Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999\u20132000","volume":"160","author":"K Radimer","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6546","DOI":"10.1073\/pnas.84.18.6546","article-title":"Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation","volume":"84","author":"CA Luhrs","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","first-page":"5329","article-title":"Folate-binding protein is a marker for ovarian cancer","volume":"51","author":"IG Campbell","year":"1991","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1681\/ASN.V34895","article-title":"Glycosyl-phosphatidylinositol-anchored membrane proteins","volume":"3","author":"D Brown","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1182\/blood.V42.2.281.281","article-title":"Measurement of serum folate levels and serum folic acid-binding protein by 3H-PGA radioassay","volume":"42","author":"S Waxman","year":"1973","journal-title":"Blood"},{"key":"ref25","first-page":"207","article-title":"Appearance of a folate binder in leukocytes and serum of women who are pregnant or taking oral contraceptives","volume":"83","author":"M Da Costa","year":"1974","journal-title":"J Lab Clin Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1182\/blood.V48.6.911.911","article-title":"Total folate binding capacity of normal human plasma, and variations in uremia, cirrhosis, and pregnancy","volume":"48","author":"N Colman","year":"1976","journal-title":"Blood"},{"key":"ref27","first-page":"81","article-title":"Hormonal dependence of folic acid protein binding in human serum","volume":"44","author":"T Markkanen","year":"1974","journal-title":"Int J Vitam Nutr Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1753-4887.1982.tb05320.x","article-title":"Serum folate binders are not correlated to folate nutritional status","volume":"40","journal-title":"Nutr Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e6292","DOI":"10.1371\/journal.pone.0006292","article-title":"Functional folate receptor alpha is elevated in the blood of ovarian cancer patients","volume":"4","author":"E Basal","year":"2009","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.clinbiochem.2013.03.010","article-title":"Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients","volume":"46","author":"F Leung","year":"2013","journal-title":"Clin Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1757-2215-6-29","article-title":"Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4","volume":"6","author":"DJ O\u2019Shannessy","year":"2013","journal-title":"J Ovarian Res"},{"key":"ref32","first-page":"51","article-title":"Population-based cohort development in Alberta, Canada: a feasibility study","volume":"27","author":"H Bryant","year":"2006","journal-title":"Chronic Dis Can"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1017\/S1368980007184287","article-title":"Adaptation and evaluation of the National Cancer Institute\u2019s Diet History Questionnaire and nutrient database for Canadian populations","volume":"10","author":"I Csizmadi","year":"2007","journal-title":"Public Health Nutr"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s13277-010-0074-0","article-title":"All-trans retinoic acid is capable of inducing folate receptor beta expression in KG-1 cells","volume":"31","author":"Y Xu","year":"2010","journal-title":"Tumour Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijpharm.2010.09.019","article-title":"Targeting human clonogenic acute myelogenous leukemia cells via folate conjugated liposomes combined with receptor modulation by all-trans retinoic acid","volume":"402","author":"H Li","year":"2010","journal-title":"Int J Pharm"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/carcin\/21.2.189","article-title":"Polymorphisms in the human aromatase cytochrome P450 gene (CYP19) and breast cancer risk","volume":"21","author":"CS Healey","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref37","unstructured":"Institute of Medicine (2001) Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, DC: National Academy Press."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9951","DOI":"10.1021\/bi00031a018","article-title":"Structural and functional analysis of the human KB cell folate receptor gene P4 promoter: cooperation of three clustered Sp1-binding sites with initiator region for basal promoter activity","volume":"34","author":"Y Saikawa","year":"1995","journal-title":"Biochemistry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1021\/bi962070h","article-title":"The divergent 5\u2032 termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure","volume":"36","author":"PC Elwood","year":"1997","journal-title":"Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T09:04:50Z","timestamp":1648976690000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096542"}},"subtitle":[],"editor":[{"given":"Arun","family":"Rishi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,8]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096542","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,8]]}}}