{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:33:25Z","timestamp":1779910405478,"version":"3.53.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T00:00:00Z","timestamp":1402617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0096777","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T20:19:08Z","timestamp":1402690748000},"page":"e96777","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Modulatory Effect of Acupuncture at Waiguan (TE5) on the Functional Connectivity of the Central Nervous System of Patients with Ischemic Stroke in the Left Basal Ganglia"],"prefix":"10.1371","volume":"9","clinical-trial-number":[{"clinical-trial-number":"chictr-onrc-08000255","registry":"10.18810\/chictr"}],"author":[{"given":"Junqi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinsheng","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunzhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongjun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,13]]},"reference":[{"key":"ref1","first-page":"1518","article-title":"NIH Consensus Conference. Acupuncture","volume":"280","journal-title":"JAMA"},{"key":"ref2","unstructured":"Cheng XN (2000) Chinese Acupuncture and Moxibustion. Beijing: People\u2019s Medical Publishing House."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-2236(02)00006-1","article-title":"Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies","volume":"26","author":"JS Han","year":"2003","journal-title":"Trends Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jmri.21805","article-title":"Combining spatial and temporal information to explore function-guide action of acupuncture using fMRI","volume":"30","author":"P Liu","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1142\/S0192415X12500528","article-title":"Commonality and specificity of acupuncture action at three acupoints as evidenced by FMRI","volume":"40","author":"JD Claunch","year":"2012","journal-title":"Am J Chin Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.04.027","article-title":"Comparison of visual cortical activations induced by electro-acupuncture at vision and nonvision-related acupoints","volume":"458","author":"Y Zhang","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Hui KK, Napadow V, Liu J, Li M, Marina O, et al. (2010) Monitoring acupuncture effects on human brain by FMRI. J Vis Exp.","DOI":"10.3791\/1190"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e32960","DOI":"10.1371\/journal.pone.0032960","article-title":"Characterizing acupuncture stimuli using brain imaging with FMRI\u2013a systematic review and meta-analysis of the literature","volume":"7","author":"W Huang","year":"2012","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jmri.22393","article-title":"Divergent neural processes specific to the acute and sustained phases of verum and SHAM acupuncture","volume":"33","author":"J Liu","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.mri.2012.01.003","article-title":"FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients","volume":"30","author":"Y Feng","year":"2012","journal-title":"Magn Reson Imaging"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2009.07.015","article-title":"Partial correlation investigation on the default mode network involved in acupuncture: an fMRI study","volume":"462","author":"P Liu","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1142\/S0192415X11009111","article-title":"Variations of brain activities of acupuncture to TE5 of left hand in normal subjects","volume":"39","author":"SF Hsu","year":"2011","journal-title":"Am J Chin Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1744-8069-4-55","article-title":"FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network","volume":"4","author":"W Qin","year":"2008","journal-title":"Mol Pain"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2009.06.061","article-title":"Acupuncture mobilizes the brain\u2019s default mode and its anti-correlated network in healthy subjects","volume":"1287","author":"KK Hui","year":"2009","journal-title":"Brain Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pain.2008.01.011","article-title":"Acupuncture modulates resting state connectivity in default and sensorimotor brain networks","volume":"136","author":"RP Dhond","year":"2008","journal-title":"Pain"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tics.2004.07.008","article-title":"Organization, development and function of complex brain networks","volume":"8","author":"O Sporns","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/ana.21228","article-title":"Cortical connectivity after subcortical stroke assessed with functional magnetic resonance imaging","volume":"63","author":"C Grefkes","year":"2008","journal-title":"Ann Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/brain\/awq043","article-title":"Dynamic functional reorganization of the motor execution network after stroke","volume":"133","author":"L Wang","year":"2010","journal-title":"Brain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1545968308322840","article-title":"Motor network changes associated with successful motor skill relearning after acute ischemic stroke: a longitudinal functional magnetic resonance imaging study","volume":"23","author":"T Askim","year":"2009","journal-title":"Neurorehabil Neural Repair"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/hbm.21227","article-title":"Relationship between functional connectivity and sensory impairment: red flag or red herring","volume":"33","author":"M Dinomais","year":"2012","journal-title":"Hum Brain Mapp"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1126\/science.272.5261.545","article-title":"Cerebellum implicated in sensory acquisition and discrimination rather than motor control","volume":"272","author":"JH Gao","year":"1996","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/cercor\/bhp157","article-title":"Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity","volume":"20","author":"JX O\u2019Reilly","year":"2010","journal-title":"Cereb Cortex"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1088\/0954-898X_14_4_305","article-title":"Modulation of excitatory synaptic coupling facilitates synchronization and complex dynamics in a biophysical model of neuronal dynamics","volume":"14","author":"M Breakspear","year":"2003","journal-title":"Network"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/brain\/awr033","article-title":"Reorganization of cerebral networks after stroke: new insights from neuroimaging with connectivity approaches","volume":"134","author":"C Grefkes","year":"2011","journal-title":"Brain"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/brain\/awh369","article-title":"Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke","volume":"128","author":"F Hummel","year":"2005","journal-title":"Brain"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/ana.10848","article-title":"Influence of interhemispheric interactions on motor function in chronic stroke","volume":"55","author":"N Murase","year":"2004","journal-title":"Ann Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2007.02.013","article-title":"Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect","volume":"53","author":"BJ He","year":"2007","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.1002431107","article-title":"Double dissociation of two cognitive control networks in patients with focal brain lesions","volume":"107","author":"EM Nomura","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1002\/hbm.20583","article-title":"The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation","volume":"30","author":"J Fang","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Huang Y, Chen JQ, Lai XS, Tang CZ, Yang JJ, et al. (2013) Lateralisation of cerebral response to active acupuncture in patients with unilateral ischaemic stroke: an fMRI study. Acupunct Med.","DOI":"10.1136\/acupmed-2012-010299"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/acm.2007.6316","article-title":"Correlated change in upper limb function and motor cortex activation after verum and sham acupuncture in patients with chronic stroke","volume":"13","author":"JD Schaechter","year":"2007","journal-title":"J Altern Complement Med"},{"key":"ref32","unstructured":"Maciocia G (1994) The practice of Chinese medicine: the treatment of diseases with acupuncture and Chinese herbs. Edinburgh, UK: Churchill Livingstone. 342\u2013385 p."},{"key":"ref33","first-page":"981","article-title":"Study on the effects of acupuncture at acupoint and non-acupoint on functional connectivity of different brain regions with functional magnetic resonance imaging","volume":"29","author":"B Liu","year":"2009","journal-title":"Zhongguo Zhen Jiu"},{"key":"ref34","unstructured":"(1999) MONICA Manual."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"AE Cavanna","year":"2006","journal-title":"Brain"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/brain\/awf282","article-title":"Correlation between motor improvements and altered fMRI activity after rehabilitative therapy","volume":"125","author":"H Johansen-Berg","year":"2002","journal-title":"Brain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"14518","DOI":"10.1073\/pnas.222536799","article-title":"The role of ipsilateral premotor cortex in hand movement after stroke","volume":"99","author":"H Johansen-Berg","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/brain\/awf148","article-title":"Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke","volume":"125","author":"SL Small","year":"2002","journal-title":"Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0304-3959(01)00444-4","article-title":"Acupuncture treatment of chronic low-back pain \u2013 a randomized, blinded, placebo-controlled trial with 9-month follow-up","volume":"96","author":"E Leibing","year":"2002","journal-title":"Pain"},{"key":"ref40","first-page":"191","article-title":"Effect of needle acupuncture on pain perception and functional impairment of patients with coxarthrosis","volume":"59","author":"MG Fink","year":"2000","journal-title":"Z Rheumatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/j.1532-2149.2012.00145.x","article-title":"Acupuncture points are large fields: the fuzziness of acupuncture point localization by doctors in practice","volume":"16","author":"AF Molsberger","year":"2012","journal-title":"Eur J Pain"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1526-4610.2009.01424.x","article-title":"Acupuncture for treating acute attacks of migraine: a randomized controlled trial","volume":"49","author":"Y Li","year":"2009","journal-title":"Headache"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/jmri.22887","article-title":"Modulatory effects of acupuncture on resting-state networks: a functional MRI study combining independent component analysis and multivariate Granger causality analysis","volume":"35","author":"C Zhong","year":"2012","journal-title":"J Magn Reson Imaging"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/acm.2008.0356","article-title":"Sham acupuncture may be as efficacious as true acupuncture: a systematic review of clinical trials","volume":"15","author":"HH Moffet","year":"2009","journal-title":"J Altern Complement Med"},{"key":"ref45","first-page":"315","article-title":"[Thinking about the conclusion of no difference between the acupuncture and sham-acupuncture in the clinically therapeutic effects on migraine abroad]","volume":"29","author":"JJ Wang","year":"2009","journal-title":"Zhongguo Zhen Jiu"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:37:23Z","timestamp":1540287443000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096777"}},"subtitle":[],"editor":[{"given":"Cornelis","family":"Jan Stam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,13]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096777","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,13]]}}}