{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:37:36Z","timestamp":1758631056962},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0096943","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T21:26:56Z","timestamp":1399670816000},"page":"e96943","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Functional Variant of PTPN22 Confers Risk for Vogt-Koyanagi-Harada Syndrome but Not for Ankylosing Spondylitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Qi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/art.503","article-title":"Management of uveitis: a rheumatologic perspective","volume":"46","author":"JR Smith","year":"2002","journal-title":"Arthritis and rheumatism"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/02713680500263606","article-title":"Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China","volume":"30","author":"P Yang","year":"2005","journal-title":"Current eye research"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10384-012-0158-z","article-title":"The 2009 prospective multi-center epidemiologic survey of uveitis in Japan","volume":"56","author":"N Ohguro","year":"2012","journal-title":"Japanese journal of ophthalmology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10384-006-0383-4","article-title":"Epidemiological survey of intraocular inflammation in Japan","volume":"51","author":"H Goto","year":"2007","journal-title":"Japanese journal of ophthalmology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"J Braun","year":"2007","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ophtha.2006.07.040","article-title":"Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients","volume":"114","author":"P Yang","year":"2007","journal-title":"Ophthalmology"},{"key":"ref7","volume":"115","unstructured":"Yang P, Fang W, Meng Q, Ren Y, Xing L, <etal>et al<\/etal>.. (2008) Clinical features of chinese patients with Behcet&apos;s disease. Ophthalmology <volume>115<\/volume>: : 312\u2013318 e314."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ng.1005","article-title":"A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis","volume":"44","author":"Z Lin","year":"2012","journal-title":"Nature genetics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng.513","article-title":"Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci","volume":"42","author":"JD Reveille","year":"2010","journal-title":"Nature genetics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.humimm.2010.06.020","article-title":"Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behcet&apos;s disease in a Chinese Han population","volume":"71","author":"Q Shu","year":"2010","journal-title":"Human immunology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.4049\/jimmunol.165.12.7323","article-title":"Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease","volume":"165","author":"K Yamaki","year":"2000","journal-title":"Journal of immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","article-title":"Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet&apos;s disease susceptibility loci","volume":"42","author":"N Mizuki","year":"2010","journal-title":"Nature genetics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/ng.914","article-title":"Lyp breakdown and autoimmunity","volume":"43","author":"TW Behrens","year":"2011","journal-title":"Nature genetics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/ng1204-1248","article-title":"PTPN22 and autoimmune disease","volume":"36","author":"KA Siminovitch","year":"2004","journal-title":"Nature genetics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/ng1205-1300","article-title":"Gaining insight into PTPN22 and autoimmunity","volume":"37","author":"PK Gregersen","year":"2005","journal-title":"Nature genetics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ni.2246","article-title":"Protein tyrosine phosphatases in lymphocyte activation and autoimmunity","volume":"13","author":"I Rhee","year":"2012","journal-title":"Nature immunology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.clim.2013.10.006","article-title":"Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity","volume":"149","author":"G Fousteri","year":"2013","journal-title":"Clin Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/422827","article-title":"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis","volume":"75","author":"AB Begovich","year":"2004","journal-title":"American journal of human genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1323","article-title":"A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes","volume":"36","author":"N Bottini","year":"2004","journal-title":"Nature genetics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1086\/423790","article-title":"Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE","volume":"75","author":"C Kyogoku","year":"2004","journal-title":"American journal of human genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/thy.2007.0353","article-title":"Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves&apos; disease in a Japanese population","volume":"18","author":"M Ichimura","year":"2008","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/hmg\/ddn363","article-title":"A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus","volume":"18","author":"V Orru","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10038-005-0246-8","article-title":"Ethnic differences in allele frequency of autoimmune-disease-associated SNPs","volume":"50","author":"M Mori","year":"2005","journal-title":"Journal of human genetics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/rheumatology\/kel170","article-title":"The PTPN22 C1858T functional polymorphism and autoimmune diseases\u2014a meta-analysis","volume":"46","author":"YH Lee","year":"2007","journal-title":"Rheumatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1744-313X.2008.00803.x","article-title":"PTPN22 allele polymorphisms in 15 Chinese populations","volume":"35","author":"ZH Zhang","year":"2008","journal-title":"International journal of immunogenetics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/art.24245","article-title":"Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations","volume":"60","author":"HS Lee","year":"2009","journal-title":"Arthritis and rheumatism"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/ajmg.a.31124","article-title":"Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations","volume":"140","author":"E Kawasaki","year":"2006","journal-title":"American journal of medical genetics Part A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1399-0039.2007.00871.x","article-title":"The PTPN22 promoter polymorphism -1123G&gt;C association cannot be distinguished from the 1858C&gt;T association in a Norwegian rheumatoid arthritis material","volume":"70","author":"MK Viken","year":"2007","journal-title":"Tissue antigens"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.humimm.2010.05.016","article-title":"Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population","volume":"71","author":"M Taniyama","year":"2010","journal-title":"Human immunology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00296-010-1705-x","article-title":"A PTPN22 promoter polymorphism -1123G&gt;C is associated with RA pathogenesis in Chinese","volume":"32","author":"JJ Huang","year":"2012","journal-title":"Rheumatology international"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Ge J, Li H, Gu D, Du W, Xue F, <etal>et al<\/etal>.. (2012) PTPN22 -1123G &gt; C polymorphism is associated with susceptibility to primary immune thrombocytopenia in Chinese population. Platelets.","DOI":"10.3109\/09537104.2012.730646"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e31230","DOI":"10.1371\/journal.pone.0031230","article-title":"No association of PTPN22 polymorphisms with susceptibility to ocular Behcet&apos;s disease in two Chinese Han populations","volume":"7","author":"Q Zhang","year":"2012","journal-title":"PloS one"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"S van der Linden","year":"1984","journal-title":"Arthritis and rheumatism"},{"key":"ref34","first-page":"647","article-title":"Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature","volume":"131","author":"RW Read","year":"2001","journal-title":"American journal of ophthalmology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00439-012-1200-4","article-title":"Two-stage association study in Chinese Han identifies two independent associations in CCR1\/CCR3 locus as candidate for Behcet&apos;s disease susceptibility","volume":"131","author":"S Hou","year":"2012","journal-title":"Human genetics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1016\/j.febslet.2011.04.032","article-title":"Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?","volume":"585","author":"GL Burn","year":"2011","journal-title":"FEBS letters"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/gene.2012.46","article-title":"Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue","volume":"13","author":"J Zheng","year":"2012","journal-title":"Genes and immunity"},{"key":"ref38","volume":"131","unstructured":"Chew GY, Sinha U, Gatenby PA, Demalmanche T, Adelstein S, <etal>et al<\/etal>.. (2013) Autoimmunity in primary antibody deficiency is associated with protein tyrosine phosphatase nonreceptor type 22 (PTPN22). The Journal of allergy and clinical immunology <volume>131<\/volume>: : 1130\u20131135 e1131."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.diabres.2012.04.011","article-title":"Association of the PTPN22 gene (+1858C\/T, -1123G\/C) polymorphisms with type 1 diabetes mellitus: a systematic review and meta-analysis","volume":"97","author":"S Tang","year":"2012","journal-title":"Diabetes research and clinical practice"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaut.2008.01.001","article-title":"Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22\/Lyp 620Trp variant","volume":"31","author":"J Aarnisalo","year":"2008","journal-title":"Journal of autoimmunity"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.4049\/jimmunol.179.7.4704","article-title":"Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes","volume":"179","author":"M Rieck","year":"2007","journal-title":"Journal of immunology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"828","DOI":"10.4049\/jimmunol.173.2.828","article-title":"IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice","volume":"173","author":"AC Anderson","year":"2004","journal-title":"Journal of immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ng.904","article-title":"The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp\/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness","volume":"43","author":"J Zhang","year":"2011","journal-title":"Nature genetics"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1744-313X.2005.00534.x","article-title":"A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn&apos;s disease","volume":"32","author":"SE Wagenleiter","year":"2005","journal-title":"International journal of immunogenetics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-0039.2005.00428.x","article-title":"The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease","volume":"66","author":"MC Martin","year":"2005","journal-title":"Tissue Antigens"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s00415-005-0795-y","article-title":"Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis","volume":"252","author":"F Matesanz","year":"2005","journal-title":"Journal of neurology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1136\/ard.2005.048181","article-title":"Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population","volume":"65","author":"J Wipff","year":"2006","journal-title":"Annals of the rheumatic diseases"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/ard.2005.046094","article-title":"Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity","volume":"65","author":"G Orozco","year":"2006","journal-title":"Annals of the rheumatic diseases"},{"key":"ref49","first-page":"208","article-title":"Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort","volume":"15","author":"TM Martin","year":"2009","journal-title":"Molecular vision"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Huang CH, Wei JC, Chen CC, Chuang CS, Chou CH, <etal>et al<\/etal>.. (2013) Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis. Rheumatol Int.","DOI":"10.1007\/s00296-013-2894-x"},{"key":"ref51","first-page":"1115","article-title":"Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients","volume":"15","author":"Y Horie","year":"2009","journal-title":"Molecular vision"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A proposed classification of the immunological diseases","volume":"3","author":"D McGonagle","year":"2006","journal-title":"PLoS medicine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T10:19:36Z","timestamp":1565432376000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096943"}},"subtitle":[],"editor":[{"given":"Graham R.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,9]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096943","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,9]]}}}