{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:54:16Z","timestamp":1778273656676,"version":"3.51.4"},"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0096987","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T20:29:17Z","timestamp":1400099357000},"page":"e96987","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Transcriptome-Based Analysis of Kidney Gene Expression Changes Associated with Diabetes in OVE26 Mice, in the Presence and Absence of Losartan Treatment"],"prefix":"10.1371","volume":"9","author":[{"given":"Radko","family":"Komers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Kantharidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert T.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(98)01346-4","article-title":"Pathogenesis, prevention, and treatment of diabetic nephropathy","volume":"352","author":"ME Cooper","year":"1998","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mcna.2012.10.008","article-title":"Clinical manifestations and natural history of diabetic kidney disease","volume":"97","author":"E Ritz","year":"2013","journal-title":"Med Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/cphy.c100049","article-title":"Pathophysiology of the diabetic kidney","volume":"1","author":"V Vallon","year":"2011","journal-title":"Compr Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1152\/physiolgenomics.00231.2004","article-title":"Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes","volume":"21","author":"KE Knoll","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1159\/000324407","article-title":"Inflammatory gene expression in OVE26 diabetic kidney during the development of nephropathy","volume":"119","author":"L Yang","year":"2011","journal-title":"Nephron Exp Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1159\/000327586","article-title":"Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression","volume":"119","author":"S Zheng","year":"2011","journal-title":"Nephron Exp Nephrol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e44714","DOI":"10.1371\/journal.pone.0044714","article-title":"Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes","volume":"7","author":"MA Jaffa","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.2337\/diabetes.53.12.3248","article-title":"Development of late-stage diabetic nephropathy in OVE26 diabetic mice","volume":"53","author":"S Zheng","year":"2004","journal-title":"Diabetes"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0092-8674(89)90505-9","article-title":"Calmodulin-induced early-onset diabetes in transgenic mice","volume":"58","author":"PN Epstein","year":"1989","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"F487","DOI":"10.1152\/ajprenal.00018.2010","article-title":"FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria","volume":"299","author":"J Xu","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nat Protoc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2337\/db05-1595","article-title":"Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney","volume":"55","author":"R Komers","year":"2006","journal-title":"Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"BM Brenner","year":"2001","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"C594","DOI":"10.1152\/ajpcell.1991.261.4.C594","article-title":"Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells","volume":"261","author":"DM Cohen","year":"1991","journal-title":"Am J Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"49390","DOI":"10.1074\/jbc.M107517200","article-title":"Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain","volume":"276","author":"A Chairoungdua","year":"2001","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-1119(02)00435-3","article-title":"Homologues of amino acid permeases: cloning and tissue expression of XAT1 and XAT2","volume":"286","author":"JP Blondeau","year":"2002","journal-title":"Gene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.2337\/dc08-0659","article-title":"Risk factors related to inflammation and endothelial dysfunction in the DCCT\/EDIC cohort and their relationship with nephropathy and macrovascular complications","volume":"31","author":"MF Lopes-Virella","year":"2008","journal-title":"Diabetes Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/HJH.0b013e328362b7fa","article-title":"Angiotensin receptor blocker therapy and risk of cancer","volume":"31","author":"KK Teo","year":"2013","journal-title":"J Hypertens"},{"key":"ref21","first-page":"50","article-title":"Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies","volume":"296","author":"FS Collins","year":"2007","journal-title":"Sci Am"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/CS20130065","article-title":"Nox as a target for diabetic complications","volume":"125","author":"Y Gorin","year":"2013","journal-title":"Clin Sci (Lond)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","article-title":"The SLC3 and SLC7 families of amino acid transporters","volume":"34","author":"D Fotiadis","year":"2013","journal-title":"Mol Aspects Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"778","DOI":"10.5301\/JN.2011.6382","article-title":"Gene expression profiling in ethnic Malays with type 2 diabetes mellitus, with and without diabetic nephropathy","volume":"24","author":"FE Lokman","year":"2011","journal-title":"J Nephrol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000089849","article-title":"SGK1-mediated fibronectin formation in diabetic nephropathy","volume":"16","author":"Y Feng","year":"2005","journal-title":"Cell Physiol Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ki.2010.214","article-title":"Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition","volume":"78","author":"J Cheng","year":"2010","journal-title":"Kidney Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1681\/ASN.2010080827","article-title":"The WNK kinase network regulating sodium, potassium, and blood pressure","volume":"22","author":"EJ Hoorn","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0272-6386(98)70075-7","article-title":"Preferential expression of insulin-like growth factor binding proteins-1, -3, and -5 during early diabetic renal hypertrophy in rats","volume":"32","author":"IS Park","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"E563","DOI":"10.1152\/ajpendo.00591.2011","article-title":"Genetic disruption of soluble epoxide hydrolase is protective against streptozotocin-induced diabetic nephropathy","volume":"303","author":"G Chen","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1681\/ASN.V11125","article-title":"Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis","volume":"11","author":"BL Riser","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1007\/s00216-012-6412-x","article-title":"Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy","volume":"404","author":"A Hirayama","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2009.05356.x","article-title":"Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism","volume":"1199","author":"GF Oxenkrug","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","first-page":"453","article-title":"The protective effect of telmisartan in type 2 diabetes rat kidneys is related to the downregulation of thioredoxin-interacting protein","volume":"36","author":"J Wu","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1074\/jbc.M112.419101","article-title":"Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells","volume":"288","author":"A Shah","year":"2013","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MOL.0b013e3283630cf0","article-title":"The angiopoietin-like protein 3: a hepatokine with expanding role in metabolism","volume":"24","author":"M Arca","year":"2013","journal-title":"Curr Opin Lipidol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"S Kathiresan","year":"2008","journal-title":"Nat Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbrc.2010.07.027","article-title":"Angiopoietin-like protein 3 regulates the motility and permeability of podocytes by altering nephrin expression in vitro","volume":"399","author":"X Gao","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2337\/db09-0801","article-title":"Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands","volume":"59","author":"D Yao","year":"2010","journal-title":"Diabetes"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1172\/JCI10963","article-title":"Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes","volume":"107","author":"SC Thomson","year":"2001","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e3280","DOI":"10.1371\/journal.pone.0003280","article-title":"Species specificity in major urinary proteins by parallel evolution","volume":"3","author":"DW Logan","year":"2008","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0083-6729(10)83006-7","article-title":"Major urinary protein regulation of chemical communication and nutrient metabolism","volume":"83","author":"Y Zhou","year":"2010","journal-title":"Vitam Horm"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"14050","DOI":"10.1074\/jbc.M109.001107","article-title":"Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice","volume":"284","author":"X Hui","year":"2009","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11152","DOI":"10.1074\/jbc.M900754200","article-title":"Identification of MUP1 as a regulator for glucose and lipid metabolism in mice","volume":"284","author":"Y Zhou","year":"2009","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1073\/pnas.0305300101","article-title":"Temporal linkage between the phenotypic and genomic responses to caloric restriction","volume":"101","author":"JM Dhahbi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1210\/me.2002-0142","article-title":"Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice","volume":"16","author":"RA Miller","year":"2002","journal-title":"Mol Endocrinol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jash.2008.11.002","article-title":"Purification and mechanism of action of \u201ccortexin,\u201d a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men","volume":"3","author":"S Chakraborty","year":"2009","journal-title":"J Am Soc Hypertens"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/ibd.21647","article-title":"C1q\/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts","volume":"17","author":"C Hofmann","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.2337\/db12-0217","article-title":"C1q\/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome","volume":"61","author":"KM Choi","year":"2012","journal-title":"Diabetes"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"31317","DOI":"10.1074\/jbc.M703951200","article-title":"S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains","volume":"282","author":"E Leclerc","year":"2007","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"R Zhou","year":"2010","journal-title":"Nat Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"15425","DOI":"10.1073\/pnas.1208031109","article-title":"Structural basis for activation of the complement system by component C4 cleavage","volume":"109","author":"RT Kidmose","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0002-9440(10)64268-X","article-title":"Deletion of decay-accelerating factor (CD55) exacerbates autoimmune disease development in MRL\/lpr mice","volume":"161","author":"T Miwa","year":"2002","journal-title":"Am J Pathol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.4049\/jimmunol.179.11.7729","article-title":"Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense","volume":"179","author":"D Degrandi","year":"2007","journal-title":"J Immunol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1081\/JDI-100104729","article-title":"Connective tissue growth factor and its regulation: a new element in diabetic glomerulosclerosis","volume":"23","author":"BL Riser","year":"2001","journal-title":"Ren Fail"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1046\/j.1523-1755.2001.00776.x","article-title":"Connective tissue growth factor in tubulointerstitial injury of diabetic nephropathy","volume":"60","author":"S Wang","year":"2001","journal-title":"Kidney Int"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrg2884","article-title":"Analysing biological pathways in genome-wide association studies","volume":"11","author":"K Wang","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2337\/db11-0402","article-title":"Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin","volume":"61","author":"S Miyamoto","year":"2012","journal-title":"Diabetes"},{"key":"ref58","first-page":"5196","article-title":"Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray","volume":"62","author":"RK Thimmulappa","year":"2002","journal-title":"Cancer Res"},{"key":"ref59","first-page":"216512","article-title":"Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy","volume":"2012","author":"B Li","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1681\/ASN.2012050457","article-title":"Bardoxolone methyl decreases megalin and activates nrf2 in the kidney","volume":"23","author":"SA Reisman","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0891-5849(97)00463-2","article-title":"Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes","volume":"24","author":"S Puntarulo","year":"1998","journal-title":"Free Radic Biol Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2337\/db08-1536","article-title":"Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases","volume":"58","author":"AA Eid","year":"2009","journal-title":"Diabetes"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.prostaglandins.2011.06.009","article-title":"Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice","volume":"96","author":"G Chen","year":"2011","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","article-title":"The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha","volume":"91","author":"C Hetz","year":"2011","journal-title":"Physiol Rev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1681\/ASN.2007121313","article-title":"Proteinuria and hyperglycemia induce endoplasmic reticulum stress","volume":"19","author":"MT Lindenmeyer","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bbrc.2008.04.031","article-title":"Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease","volume":"370","author":"G Liu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.2353\/ajpath.2010.090386","article-title":"Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation","volume":"176","author":"J Wu","year":"2010","journal-title":"Am J Pathol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1172\/JCI118994","article-title":"150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein","volume":"98","author":"Y Tsukamoto","year":"1996","journal-title":"J Clin Invest"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/sj.emboj.7600777","article-title":"ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth","volume":"24","author":"M Bi","year":"2005","journal-title":"EMBO J"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2119\/molmed.2011.00131","article-title":"Endoplasmic reticulum stress implicated in the development of renal fibrosis","volume":"17","author":"CK Chiang","year":"2011","journal-title":"Mol Med"},{"key":"ref71","first-page":"507986","article-title":"Endoplasmic reticulum stress-related factors protect against diabetic retinopathy","volume":"2012","author":"WK Hu","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref72","first-page":"21","article-title":"Response of renal medullary cells to osmotic stress","volume":"148","author":"FX Beck","year":"2005","journal-title":"Contrib Nephrol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1161\/ATVBAHA.112.249318","article-title":"Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice","volume":"32","author":"M Kassan","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1172\/JCI64583","article-title":"ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension","volume":"122","author":"CN Young","year":"2012","journal-title":"J Clin Invest"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.tox.2011.11.008","article-title":"Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1\u20137)-mas axis","volume":"291","author":"S Arumugam","year":"2012","journal-title":"Toxicology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ejps.2011.10.009","article-title":"Modulation of AT-1R\/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice","volume":"44","author":"AP Lakshmanan","year":"2011","journal-title":"Eur J Pharm Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"L33","DOI":"10.1152\/ajplung.00001.2013","article-title":"Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1\u20137","volume":"305","author":"BD Uhal","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.freeradbiomed.2008.08.013","article-title":"Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production","volume":"45","author":"SI Dikalov","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMoa0808400","article-title":"Renal and retinal effects of enalapril and losartan in type 1 diabetes","volume":"361","author":"M Mauer","year":"2009","journal-title":"N Engl J Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/path.4121","article-title":"Wnt signalling in kidney diseases: dual roles in renal injury and repair","volume":"229","author":"T Kawakami","year":"2013","journal-title":"J Pathol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"F911","DOI":"10.1152\/ajprenal.00037.2005","article-title":"Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis","volume":"289","author":"R Mathew","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00439-005-0019-7","article-title":"Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians","volume":"118","author":"AR Red Eagle","year":"2005","journal-title":"Hum Genet"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"CV Dang","year":"2012","journal-title":"Cell"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"EA Musgrove","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/387296a0","article-title":"Mdm2 promotes the rapid degradation of p53","volume":"387","author":"Y Haupt","year":"1997","journal-title":"Nature"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ccr.2008.10.016","article-title":"HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma","volume":"14","author":"JD Gordan","year":"2008","journal-title":"Cancer Cell"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"4674","DOI":"10.1158\/0008-5472.CAN-09-0146","article-title":"Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney","volume":"69","author":"R Beroukhim","year":"2009","journal-title":"Cancer Res"},{"key":"ref88","first-page":"3014","article-title":"VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells","volume":"62","author":"RS Bindra","year":"2002","journal-title":"Cancer Res"},{"key":"ref89","first-page":"3803","article-title":"Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease","volume":"62","author":"M Zatyka","year":"2002","journal-title":"Cancer Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/jnci\/86.17.1325","article-title":"Altered patterns of MDM2 and TP53 expression in human bladder cancer","volume":"86","author":"P Lianes","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1200\/JCO.2011.35.1908","article-title":"Angiotensin receptor blockade and risk of cancer in type 2 diabetes mellitus: a nationwide case-control study","volume":"29","author":"CH Chang","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S1470-2045(10)70106-6","article-title":"Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials","volume":"11","author":"I Sipahi","year":"2010","journal-title":"Lancet Oncol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/HJH.0b013e328344a7de","article-title":"Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrolling 138,769 individuals","volume":"29","author":"ARBT Collaboration","year":"2011","journal-title":"J Hypertens"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1470-2045(10)70260-6","article-title":"Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials","volume":"12","author":"S Bangalore","year":"2011","journal-title":"Lancet Oncol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/jnci\/83.16.1142","article-title":"Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States?","volume":"83","author":"DR Shopland","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"E1073","DOI":"10.1503\/cmaj.101497","article-title":"Use of angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers and cancer risk: a meta-analysis of observational studies","volume":"183","author":"C Yoon","year":"2011","journal-title":"CMAJ"},{"key":"ref97","first-page":"4176","article-title":"Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis","volume":"62","author":"A Miyajima","year":"2002","journal-title":"Cancer Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1158\/1078-0432.CCR-05-2213","article-title":"Angiotensin II type 1 receptor antagonist candesartan as an angiogenic inhibitor in a xenograft model of bladder cancer","volume":"12","author":"M Kosugi","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/bjc.2011.565","article-title":"Prognonstic impact of renin-angiotensin system blockade in localised upper-tract urothelial carcinoma","volume":"106","author":"N Tanaka","year":"2012","journal-title":"Br J Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0096987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T04:05:41Z","timestamp":1689221141000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0096987"}},"subtitle":[],"editor":[{"given":"Ines","family":"Armando","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":99,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0096987","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}