{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:58:53Z","timestamp":1790380733855,"version":"4.1.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T00:00:00Z","timestamp":1399852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097105","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T21:21:24Z","timestamp":1399929684000},"page":"e97105","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Platelet-Derived Growth Factor Receptor-\u03b2 Antagonism Restores Morphine Analgesic Potency against Neuropathic Pain"],"prefix":"10.1371","volume":"9","author":[{"given":"Courtney L.","family":"Donica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard B.","family":"Gutstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"ref1","unstructured":"Board of Health Sciences Policy (2011) Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education and Research. Washington, DC: The National Academies Press. 313 p."},{"key":"ref2","unstructured":"Gutstein H, Akil H (2006) Opioid Analgesics. In: Brunton L, Lazo J, Parker K, editors. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11 ed. New York: McGraw-HIll. pp. 547\u2013590."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/bja\/81.1.58","article-title":"Opioid tolerance: the clinical perspective","volume":"81","author":"BJ Collett","year":"1998","journal-title":"Br J Anaesth"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1073\/pnas.96.14.7731","article-title":"Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions","volume":"96","author":"D Mayer","year":"1999","journal-title":"Proc Natl Acad Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nm.2633","article-title":"Blockade of PDGFR-\u03b2 Activation Eliminates Morphine Analgesic Tolerance","volume":"18","author":"Y Wang","year":"2012","journal-title":"Nature Medicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/00001756-199510010-00007","article-title":"Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats","volume":"6","author":"D Bian","year":"1995","journal-title":"Neuroreport"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(98)00956-X","article-title":"Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats","volume":"367","author":"B Przewlocka","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0014-2999(01)01308-5","article-title":"Opioids in chronic pain","volume":"429","author":"R Przewlocki","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: evidence-based recommendations","volume":"132","author":"RH Dworkin","year":"2007","journal-title":"Pain"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(99)01307-0","article-title":"Neuropathic pain: aetiology, symptoms, mechanisms, and management","volume":"353","author":"CJ Woolf","year":"1999","journal-title":"Lancet"},{"key":"ref11","first-page":"35","article-title":"Segmental spinal nerve ligation model of neuropathic pain","volume":"99","author":"JM Chung","year":"2004","journal-title":"Methods Mol Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1213\/01.ane.0000226100.46866.ea","article-title":"Intermittent lumbar puncture in rats: a novel method for the experimental study of opioid tolerance","volume":"103","author":"JJ Xu","year":"2006","journal-title":"Anesthesia & Analgesia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"WJ Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"SR Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(24)38879-2","article-title":"Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors","volume":"295","author":"E Buchdunger","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.med.57.121304.131324","article-title":"New treatments for neuropathic pain","volume":"57","author":"ASC Rice","year":"2006","journal-title":"Annual Review of Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/dbio.1993.1044","article-title":"Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia","volume":"155","author":"PA Eccleston","year":"1993","journal-title":"Dev Biol"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Masuda J, Tsuda M, Tozaki-Saitoh H, Inoue K (2009) Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia. Molecular Pain. 2009\/05\/12 ed. pp. 23.","DOI":"10.1186\/1744-8069-5-23"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-3806(92)90246-S","article-title":"Platelet-derived growth factor B-chain-like immunoreactivity in the developing and adult rat brain","volume":"68","author":"A Sasahara","year":"1992","journal-title":"Brain Res Dev Brain Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0092-8674(91)90223-L","article-title":"PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model","volume":"64","author":"M Sasahara","year":"1991","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(95)00073-2","article-title":"Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions","volume":"62","author":"J Mao","year":"1995","journal-title":"Pain"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T21:57:46Z","timestamp":1746223066000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097105"}},"subtitle":[],"editor":[{"given":"Shilpa J.","family":"Buch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,12]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097105","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,12]]}}}