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Immunohistochemical re-examination of cases previously diagnosed as cutaneous \u201chistiocytic lymphoma\u201d and \u201cmalignant histiocytosis\u201d","volume":"20","author":"E Arai","year":"1993","journal-title":"J Cutan Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1097\/00000478-199811000-00009","article-title":"True histiocytic lymphoma: a morphologic, immunohistochemical, and molecular genetic study of 13 cases","volume":"22","author":"C Copie-Bergman","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","article-title":"Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases","volume":"41","author":"SA Pileri","year":"2002","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/01.pas.0000131541.95394.23","article-title":"Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy","volume":"28","author":"JL Hornick","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/modpathol.3800346","article-title":"Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163","volume":"18","author":"JA Vos","year":"2005","journal-title":"Mod Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/0300985810363705","article-title":"The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice","volume":"47","author":"X Hao","year":"2010","journal-title":"Veterinary pathology"},{"key":"ref8","first-page":"428279","article-title":"Cytogenetics findings in a histiocytic sarcoma case","volume":"2012","author":"JM Alonso-Dominguez","year":"2012","journal-title":"Case Report Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s12185-010-0603-z","article-title":"Histiocytic sarcoma and underlying chronic myelomonocytic leukemia: a proposal for the developmental classification of histiocytic sarcoma","volume":"92","author":"M Mori","year":"2010","journal-title":"Int J Hematol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2407-11-201","article-title":"Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior","volume":"11","author":"B Hedan","year":"2011","journal-title":"BMC Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1055-9965.EPI-12-0190-T","article-title":"The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer","volume":"21","author":"AL Shearin","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccr.2006.03.028","article-title":"The PTEN and INK4A\/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans","volume":"9","author":"DR Carrasco","year":"2006","journal-title":"Cancer Cell"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Mashima R, Honda K, Yang Y, Morita Y, Inoue A, <etal>et al<\/etal>.. (2010) Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. 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(2012) Gender bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. 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(2012) A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2\/Src-2 in liver cancer. Proceedings of the National Academy of Sciences of the United States of America.","DOI":"10.1073\/pnas.1115433109"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Quintana RM, Dupuy AJ, Bravo A, Casanova ML, Alameda JP, <etal>et al<\/etal>.. (2012) A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development. 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ACM SIGMOD Record. ACM. pp. 207\u2013216.","DOI":"10.1145\/170036.170072"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1109\/69.250074","article-title":"Database mining: A performance perspective","volume":"5","author":"R Agrawal","year":"1993","journal-title":"Knowledge and Data Engineering, IEEE Transactions on"},{"key":"ref39","unstructured":"Zaki MJ, Ogihara M (1998) Theoretical foundations of association rules. 3rd ACM SIGMOD Workshop on Research Issues in Data Mining and Knowledge Discovery. Citeseer. pp. 71\u201378."},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Pasquier N, Bastide Y, Taouil R, Lakhal L (1999) Discovering Frequent Closed Itemsets for Association Rules. In: C Beeri and P Buneman, editors. Database Theory \u2014 ICDT&apos;99. Springer Berlin Heidelberg. pp. 398\u2013416.","DOI":"10.1007\/3-540-49257-7_25"},{"key":"ref41","unstructured":"Agrawal R, Srikant R (1994) Fast Algorithms for Mining Association Rules in Large Databases. Proceedings of the 20th International Conference on Very Large Data Bases. Morgan Kaufmann Publishers Inc. pp. 487\u2013499."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"JD Storey","year":"2002","journal-title":"Journal of the Royal Statistical Society: Series B (Statistical Methodology)"},{"key":"ref44","unstructured":"TCGARN (2013) Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia. The New England journal of medicine."},{"key":"ref45","first-page":"131","article-title":"A Survey of Exact Inference for Contingency Tables","volume":"7","author":"A Agresti","year":"1992","journal-title":"Staistical Science"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/gene.20042","article-title":"Tissue-specific and inducible Cre-mediated recombination in the gut epithelium","volume":"39","author":"F el Marjou","year":"2004","journal-title":"Genesis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1182\/blood.V96.2.719","article-title":"Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages","volume":"96","author":"N Faust","year":"2000","journal-title":"Blood"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1128\/MCB.20.20.7419-7426.2000","article-title":"Retroviral expression in embryonic stem cells and 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