{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:21:51Z","timestamp":1778275311252,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097318","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T20:32:58Z","timestamp":1400099578000},"page":"e97318","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevention of the Disrupted Enamel Phenotype in Slc4a4-Null Mice Using Explant Organ Culture Maintained in a Living Host Kidney Capsule"],"prefix":"10.1371","volume":"9","author":[{"given":"Xin","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Paine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1359\/JBMR.041002","article-title":"Mineral acquisition rates in developing enamel on maxillary and mandibular incisors of rats and mice: implications to extracellular acid loading as apatite crystals mature","volume":"20","author":"CE Smith","year":"2005","journal-title":"J Bone Miner Res"},{"key":"ref2","unstructured":"Nanci A (2008) Ten Cate's Oral Histology: Development, Structure, and Function. St. Louis, Missouri: Mosby Elsevier."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00223-009-9326-7","article-title":"Regulation of pH During Amelogenesis","volume":"86","author":"RS Lacruz","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1152\/physrev.00023.2012","article-title":"The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters","volume":"93","author":"MD Parker","year":"2013","journal-title":"Physiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Kurtz I (2013) SLC4 Sodium-driven bicarbonate transporters; Alperin RJ, Caplan M, Moe OW, editors. Amsterdam; Boston: Elsevier\/Academic Press. 1837\u20131860 p.","DOI":"10.1016\/B978-0-12-381462-3.00053-7"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-1119(00)00204-3","article-title":"Structural organization of the human NBC1 gene: kNBC1 is transcribed from an alternative promoter in intron 3","volume":"251","author":"N Abuladze","year":"2000","journal-title":"Gene"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1085\/jgp.200609520","article-title":"Electrogenic Na\/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini","volume":"127","author":"SD McAlear","year":"2006","journal-title":"J Gen Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ygeno.2011.04.010","article-title":"Cloning and identification of two novel NBCe1 splice variants from mouse reproductive tract tissues: a comparative study of NCBT genes","volume":"98","author":"Y Liu","year":"2011","journal-title":"Genomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/154405910808700415","article-title":"Role of NBCe1 and AE2 in Secretory Ameloblasts","volume":"87","author":"ML Paine","year":"2008","journal-title":"J Dent Res"},{"key":"ref10","first-page":"324","article-title":"Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1)","volume":"12","author":"FY Demirci","year":"2006","journal-title":"Mol Vis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"52238","DOI":"10.1074\/jbc.M406591200","article-title":"A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1\/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects","volume":"279","author":"D Dinour","year":"2004","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s00424-004-1278-1","article-title":"Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis","volume":"448","author":"J Inatomi","year":"2004","journal-title":"Pflugers Arch"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"24432","DOI":"10.1074\/jbc.M110.115188","article-title":"The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition","volume":"285","author":"RS Lacruz","year":"2010","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9042","DOI":"10.1074\/jbc.M607041200","article-title":"Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+\/HCO3- cotransporter","volume":"282","author":"LR Gawenis","year":"2007","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrneph.2010.33","article-title":"Metabolic acidosis: pathophysiology, diagnosis and management","volume":"6","author":"JA Kraut","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1053\/ajkd.2001.27688","article-title":"Use of base in the treatment of severe acidemic states","volume":"38","author":"JA Kraut","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1095\/biolreprod40.4.861","article-title":"Role of uterine epithelium in the development of myometrial smooth muscle cells","volume":"40","author":"GR Cunha","year":"1989","journal-title":"Biol Reprod"},{"key":"ref18","first-page":"69","article-title":"Control of ameloblast differentiation","volume":"39","author":"M Zeichner-David","year":"1995","journal-title":"Int J Dev Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/0022034512470954","article-title":"New paradigms on the transport functions of maturation-stage ameloblasts","volume":"92","author":"RS Lacruz","year":"2013","journal-title":"J Dent Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/08959374960100020701","article-title":"Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases","volume":"10","author":"CE Smith","year":"1996","journal-title":"Adv Dent Res"},{"key":"ref21","first-page":"489","article-title":"Dental features in congenetal persistent renal tubular acidosis of proximal type","volume":"92","author":"HS Koppang","year":"1984","journal-title":"Scandanavian Journal of Dental Research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bbrc.2005.12.053","article-title":"Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling","volume":"340","author":"H Harada","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/10454411980090020101","article-title":"Cellular and chemical events during enamel maturation","volume":"9","author":"CE Smith","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1177\/0022034510375829","article-title":"Regulation of dental enamel shape and hardness","volume":"89","author":"JP Simmer","year":"2010","journal-title":"J Dent Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2045-824X-3-24","article-title":"Application of microtechnologies for the vascularization of engineered tissues","volume":"3","author":"R Gauvin","year":"2011","journal-title":"Vasc Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1021\/jp077105+","article-title":"Mimicking the Self-Organized Microstructure of Tooth Enamel","volume":"112","author":"L Wang","year":"2008","journal-title":"J Phys Chem C Nanomater Interfaces"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.actbio.2011.01.028","article-title":"Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration","volume":"7","author":"Y Fan","year":"2011","journal-title":"Acta Biomater"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1177\/0022034511411301","article-title":"Leucine-rich amelogenin peptides regulate mineralization in vitro","volume":"90","author":"E Le Norcy","year":"2011","journal-title":"J Dent Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1021\/cr8004422","article-title":"Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel","volume":"108","author":"LC Palmer","year":"2008","journal-title":"Chem Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.2741\/4034","article-title":"Protein-mediated enamel mineralization","volume":"17","author":"J Moradian-Oldak","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1034\/j.1600-0722.2000.108003189.x","article-title":"Characterization of a family with dominant hypophosphatasia","volume":"108","author":"JC Hu","year":"2000","journal-title":"Eur J Oral Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/jbmr.1619","article-title":"Enzyme replacement prevents enamel defects in hypophosphatasia mice","volume":"27","author":"MC Yadav","year":"2012","journal-title":"J Bone Miner Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1067\/moe.2000.103884","article-title":"Oral findings in DiGeorge syndrome: clinical features and histologic study of primary teeth","volume":"89","author":"N Fukui","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"T Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1177\/0022034510379603","article-title":"Physiopathology of dental rickets in vitamin D receptor-ablated mice","volume":"89","author":"V Descroix","year":"2010","journal-title":"J Dent Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1073\/pnas.0502249102","article-title":"Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes","volume":"102","author":"Y Sabbagh","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1210\/endo.142.1.8050","article-title":"Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice","volume":"142","author":"R Masuyama","year":"2001","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.archoralbio.2009.09.004","article-title":"Normalisation of calcium status reverses the phenotype in dentin, but not in enamel of VDR-deficient mice","volume":"54","author":"X Zhang","year":"2009","journal-title":"Arch Oral Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.archoralbio.2009.01.002","article-title":"Different enamel and dentin mineralization observed in VDR deficient mouse model","volume":"54","author":"X Zhang","year":"2009","journal-title":"Arch Oral Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/clinchem\/42.11.1855","article-title":"Development of human renal function: reference intervals for 10 biochemical markers in fetal urine","volume":"42","author":"F Muller","year":"1996","journal-title":"Clin Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(61)91475-1","article-title":"Control of acid-base stability in the newly born","volume":"277","author":"RA McCance","year":"1961","journal-title":"The Lancet"},{"key":"ref42","first-page":"785","article-title":"Acid-Base Status of the Fetus in Human Pregnancy","volume":"22","author":"T Spackman","year":"1963","journal-title":"Obstet Gynecol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T12:11:28Z","timestamp":1597839088000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097318"}},"subtitle":[],"editor":[{"given":"Pamela Crotty","family":"Yelick","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097318","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}