{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:03:18Z","timestamp":1791356598115,"version":"4.3.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097426","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T20:24:50Z","timestamp":1400531090000},"page":"e97426","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["Bile Acid Flux Is Necessary for Normal Liver Regeneration"],"prefix":"10.1371","volume":"9","author":[{"given":"Willscott E.","family":"Naugler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"ref1","first-page":"186","article-title":"Restoration of liver of white rat following partial surgical removal","volume":"12","author":"G Higgins","year":"1931","journal-title":"Archives of Pathology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"N Fausto","year":"2006","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrm1489","article-title":"Liver regeneration: from myth to mechanism","volume":"5","author":"R Taub","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas","volume":"176","author":"GK Michalopoulos","year":"2010","journal-title":"Am J Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/hep.23059","article-title":"Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase","volume":"50","author":"U Apte","year":"2009","journal-title":"Hepatology"},{"key":"ref6","unstructured":"Huang J, Rudnick DA (2013) Elucidating the Metabolic Regulation of Liver Regeneration. Am J Pathol."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1172\/JCI59261","article-title":"Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration","volume":"121","author":"Y Malato","year":"2011","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000129215","article-title":"Decrease in regeneration capacity of rat liver after external biliary drainage","volume":"24","author":"S Iyomasa","year":"1992","journal-title":"Eur Surg Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/hep.1840200532","article-title":"Internal biliary drainage, unlike external drainage, does not suppress the regeneration of cholestatic rat liver after partial hepatectomy","volume":"20","author":"H Suzuki","year":"1994","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11596-010-0110-8","article-title":"Reduction in bile acid pool causes delayed liver regeneration accompanied by down-regulated expression of FXR and c-Jun mRNA in rats","volume":"30","author":"X Dong","year":"2010","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/bjs.8906","article-title":"External biliary drainage and liver regeneration after major hepatectomy","volume":"99","author":"R Otao","year":"2012","journal-title":"Br J Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"CJ Sinal","year":"2000","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","article-title":"Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration","volume":"312","author":"W Huang","year":"2006","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/hep.25905","article-title":"Promotion of liver regeneration\/repair by farnesoid X receptor in both liver and intestine in mice","volume":"56","author":"L Zhang","year":"2012","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Uriarte I, Fernandez-Barrena MG, Monte MJ, Latasa MU, Chang HC, <etal>et al<\/etal>.. (2013) Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice. Gut.","DOI":"10.1136\/gutjnl-2012-302945"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/hep.26463","article-title":"The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice","volume":"58","author":"N Pean","year":"2013","journal-title":"Hepatology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"33920","DOI":"10.1074\/jbc.M306370200","article-title":"Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice","volume":"278","author":"PA Dawson","year":"2003","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0016-5085(85)90499-8","article-title":"Enterohepatic circulation in the rat","volume":"88","author":"F Kuipers","year":"1985","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/08941930390194424","article-title":"Partial hepatectomy in the mouse: technique and perioperative management","volume":"16","author":"AK Greene","year":"2003","journal-title":"J Invest Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1016\/S0021-9258(19)67810-5","article-title":"Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat","volume":"266","author":"WM Pandak","year":"1991","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"T Inagaki","year":"2005","journal-title":"Cell Metab"},{"key":"ref22","first-page":"G337","article-title":"Nature of bile acid maximum secretory rate in the rat","volume":"241","author":"WG Hardison","year":"1981","journal-title":"Am J Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jhep.2010.07.012","article-title":"Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis","volume":"54","author":"I Doignon","year":"2011","journal-title":"J Hepatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/S0016-5085(99)70291-X","article-title":"Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver","volume":"117","author":"T Gerloff","year":"1999","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-0676.1990.tb00432.x","article-title":"Comparative sequential changes in serum and biliary levels of bile acid components after a single dose of D-galactosamine or partial hepatectomy in the rat","volume":"10","author":"H Tsuda","year":"1990","journal-title":"Liver"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10608","DOI":"10.1073\/pnas.0403412101","article-title":"Met provides essential signals for liver regeneration","volume":"101","author":"M Borowiak","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1073\/pnas.0306068101","article-title":"Hepatocyte growth factor\/c-met signaling pathway is required for efficient liver regeneration and repair","volume":"101","author":"CG Huh","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Paranjpe S, Bowen WC, Bell AW, Nejak-Bowen K, Luo JH, <etal>et al<\/etal>.. (2007) Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology.","DOI":"10.1002\/hep.21570"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.176.4.2522","article-title":"Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4","volume":"176","author":"JS Campbell","year":"2006","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1053\/jhep.2003.50135","article-title":"c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration","volume":"37","author":"RF Schwabe","year":"2003","journal-title":"Hepatology"},{"key":"ref31","first-page":"G552","article-title":"Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury","volume":"267","author":"AM Diehl","year":"1994","journal-title":"Am J Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15816","DOI":"10.1074\/jbc.M010878200","article-title":"Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway","volume":"276","author":"S Gupta","year":"2001","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1053\/gast.2002.32976","article-title":"Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner","volume":"122","author":"D Graf","year":"2002","journal-title":"Gastroenterology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cub.2007.10.039","article-title":"YAP1 increases organ size and expands undifferentiated progenitor cells","volume":"17","author":"FD Camargo","year":"2007","journal-title":"Curr Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"J Dong","year":"2007","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1126\/science.158.3798.272","article-title":"Regeneration of rat liver: transfer of humoral agent by cross circulation","volume":"158","author":"FL Moolten","year":"1967","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/cphy.c120014","article-title":"Principles of liver regeneration and growth homeostasis","volume":"3","author":"GK Michalopoulos","year":"2013","journal-title":"Compr Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2013.03.026","article-title":"A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration","volume":"153","author":"T Wuestefeld","year":"2013","journal-title":"Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1534-5807(02)00187-9","article-title":"Redundant pathways for negative feedback regulation of bile acid production","volume":"2","author":"L Wang","year":"2002","journal-title":"Dev Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"17707","DOI":"10.1074\/jbc.M411771200","article-title":"Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids","volume":"280","author":"C Yu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1210\/me.2008-0198","article-title":"Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration","volume":"23","author":"L Zhang","year":"2009","journal-title":"Mol Endocrinol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:18:32Z","timestamp":1649017112000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097426"}},"subtitle":[],"editor":[{"given":"Wendong","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097426","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]}}}