{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:40:28Z","timestamp":1782229228678,"version":"3.54.5"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T00:00:00Z","timestamp":1400112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097491","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T16:49:14Z","timestamp":1400172554000},"page":"e97491","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Systemic Inflammatory Response to Smoking in Chronic Obstructive Pulmonary Disease: Evidence of a Gender Effect"],"prefix":"10.1371","volume":"9","author":[{"given":"Rosa","family":"Faner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana Graciela","family":"Kalko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvar","family":"Agust\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","article-title":"Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease, GOLD Executive Summary","volume":"187","author":"J Vestbo","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1136\/bmj.1.6077.1645","article-title":"The natural history of chronic airflow obstruction","volume":"1","author":"C Fletcher","year":"1977","journal-title":"Br Med J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/rr34","article-title":"The genetics of chronic obstructive pulmonary disease","volume":"2","author":"DA Lomas","year":"2001","journal-title":"Respir Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"273S","DOI":"10.1378\/chest.117.5_suppl_1.273S","article-title":"Familial aggregation of severe, early-onset COPD: candidate gene approaches","volume":"117","author":"EK Silverman","year":"2000","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/thx.2003.012856","article-title":"Familial aggregation of FEF25-75 and FEF25-75\/FVC in families with severe, early onset COPD","volume":"59","author":"DL DeMeo","year":"2004","journal-title":"Thorax"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1056\/NEJMoa032158","article-title":"The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease","volume":"350","author":"JC Hogg","year":"2004","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e37483","DOI":"10.1371\/journal.pone.0037483","article-title":"Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype","volume":"7","author":"A Agusti","year":"2012","journal-title":"PLoS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.trsl.2013.04.003","article-title":"COPD and gender differences: an update","volume":"162","author":"S Aryal","year":"2013","journal-title":"Transl Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1378\/chest.128.4.2012","article-title":"Gender and COPD in patients attending a pulmonary clinic","volume":"128","author":"JP de Torres","year":"2005","journal-title":"Chest"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Dransfield MT, Washko GR, Foreman MG, San Jose ER, Reilly J, <etal>et al<\/etal>.. (2007) Gender differences in the severity of CT emphysema in COPD. Chest.","DOI":"10.1378\/chest.07-0863"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1564","DOI":"10.1371\/journal.pone.0001564","article-title":"Plasticity of the systemic inflammatory response to acute infection during critical illness: development of the riboleukogram","volume":"3","author":"JE McDunn","year":"2008","journal-title":"PLoS ONE"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1164\/rccm.200703-456SO","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"176","author":"KF Rabe","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1465-9921-6-22","article-title":"Acute effects of cigarette smoking on inflammation in healthy intermittent smokers","volume":"6","author":"H van der Vaart","year":"2005","journal-title":"Respir Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/thx.2003.012468","article-title":"Acute effects of cigarette smoke on inflammation and oxidative stress: a review","volume":"59","author":"H van der Vaart","year":"2004","journal-title":"Thorax"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of Spirometry. 1994 Update","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref16","first-page":"217","article-title":"Spirometric reference values for a mediterranean population","volume":"22","author":"J Roca","year":"1986","journal-title":"Bull Eur Physiopathol Respir"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.07.055","article-title":"Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments","volume":"573","author":"R Breitling","year":"2004","journal-title":"FEBS Lett"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"dW Huang","year":"2009","journal-title":"Nat Protoc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"G Dennis Jr","year":"2003","journal-title":"Genome Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1753-6561-3-s4-s6","article-title":"Biological pathway analysis by ArrayUnlock and Ingenuity Pathway Analysis","volume":"3","author":"A Jimenez-Marin","year":"2009","journal-title":"BMC Proc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/bioinformatics\/btr045","article-title":"PiNGO: a Cytoscape plugin to find candidate genes in biological networks","volume":"27","author":"M Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization","volume":"27","author":"ME Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"J144","DOI":"10.1016\/j.jaut.2011.11.004","article-title":"Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription","volume":"38","author":"R Menon","year":"2012","journal-title":"J Autoimmun"},{"key":"ref25","volume":"16","unstructured":"Anton IM, de la Fuente MA, Sims TN, Freeman S, Ramesh N, <etal>et al<\/etal>.. (2002) WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity <volume>16<\/volume>: : 193\u2013204. S1074761302002686 [pii]."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/cdd.2011.158","article-title":"BCL2A1: the underdog in the BCL2 family","volume":"19","author":"M Vogler","year":"2012","journal-title":"Cell Death Differ"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1517\/13543784.2013.778971","article-title":"Therapeutic potential of serum and glucocorticoid inducible kinase inhibition","volume":"22","author":"F Lang","year":"2013","journal-title":"Expert Opin Investig Drugs"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00412-008-0155-7","article-title":"ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein","volume":"117","author":"SL Bailey","year":"2008","journal-title":"Chromosoma"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3892\/or.2013.2413","article-title":"Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells","volume":"30","author":"A Eisenreich","year":"2013","journal-title":"Oncol Rep"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1128\/MCB.15.8.4115","article-title":"Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B","volume":"15","author":"Y Luo","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/jmbi.2000.4261","article-title":"Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II","volume":"304","author":"C Gotting","year":"2000","journal-title":"J Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"i109","DOI":"10.1136\/ard.2010.140533","article-title":"Targeting inflammation by modulating the Jun\/AP-1 pathway","volume":"70","author":"HB Schonthaler","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, <etal>et al<\/etal>.. (2013) Peripheral Blood Mononuclear Cell Gene Expression in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol.","DOI":"10.1165\/rcmb.2012-0230OC"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2043-9113-1-12","article-title":"Peripheral blood gene expression profiles in COPD subjects","volume":"1","author":"S Bhattacharya","year":"2011","journal-title":"J Clin Bioinforma"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1164\/rccm.200901-0047OC","article-title":"The Natural History of Chronic Airflow Obstruction Revisited: An Analysis of the Framingham Offspring Cohort","volume":"180","author":"R Kohansal","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e16021","DOI":"10.1371\/journal.pone.0016021","article-title":"Gender Differences in Plasma Biomarker Levels in a Cohort of COPD Patients: A Pilot Study","volume":"6","author":"JP de Torres","year":"2011","journal-title":"PLoS ONE"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0008-6363(01)00388-1","article-title":"Risk factors for coronary heart disease: implications of gender","volume":"53","author":"JE Roeters van Lennep","year":"2002","journal-title":"Cardiovasc Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.atherosclerosis.2007.02.031","article-title":"Sex related cardiovascular risk stratification based on quantification of atherosclerosis and inflammation","volume":"197","author":"R Erbel","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/01.CIR.102.20.2491","article-title":"Host response to cytomegalovirus infection as a determinant of susceptibility to coronary artery disease: sex-based differences in inflammation and type of immune response","volume":"102","author":"J Zhu","year":"2000","journal-title":"Circulation"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s10552-012-9959-0","article-title":"Lifetime risk for cancer death by sex and smoking status: the lifetime risk pooling project","volume":"23","author":"A Gawron","year":"2012","journal-title":"Cancer Causes Control"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3904\/kjim.2011.26.4.427","article-title":"Gender differences in susceptibility to smoking among patients with lung cancer","volume":"26","author":"JS Ryu","year":"2011","journal-title":"Korean J Intern Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lungcan.2009.05.017","article-title":"Lung cancer risk and cigarette smoking, lung tuberculosis according to histologic type and gender in a population based case-control study","volume":"68","author":"SK Park","year":"2010","journal-title":"Lung Cancer"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"J144","DOI":"10.1016\/j.jaut.2011.11.004","article-title":"Gender-based blood transcriptomes and interactomes in multiple sclerosis: involvement of SP1 dependent gene transcription","volume":"38","author":"R Menon","year":"2012","journal-title":"J Autoimmun"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"J282","DOI":"10.1016\/j.jaut.2011.11.013","article-title":"Sex affects immunity","volume":"38","author":"LM Pennell","year":"2012","journal-title":"J Autoimmun"},{"key":"ref45","first-page":"711","article-title":"Apoptosis and Bcl-2 family proteins, taken to chronic obstructive pulmonary disease","volume":"16","author":"H Zeng","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1586\/ers.10.61","article-title":"Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease","volume":"4","author":"SW Ryter","year":"2010","journal-title":"Expert Rev Respir Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1164\/rccm.201302-0342OC","article-title":"Histone 3.3 participates in a self-sustaining cascade of apoptosis that contributes to the progression of chronic obstructive pulmonary disease","volume":"188","author":"CA Barrero","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Faner R, Tal-Singer R, Riley JH, Celli B, Vestbo J+, <etal>et al<\/etal>.. (2013) Lessons from ECLIPSE: a review of COPD biomarkers. Thorax. In press.","DOI":"10.1136\/thoraxjnl-2013-204778"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T10:03:16Z","timestamp":1565431396000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097491"}},"subtitle":[],"editor":[{"given":"Mehrdad","family":"Arjomandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097491","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}