{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:46:59Z","timestamp":1779241619033,"version":"3.51.4"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097544","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T20:21:46Z","timestamp":1401826906000},"page":"e97544","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patterns of Gene Expression Associated with Pten Deficiency in the Developing Inner Ear"],"prefix":"10.1371","volume":"9","author":[{"given":"Hyung Jin","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihee","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Mi","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Sunghwan","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyung","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Cheol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Kyung","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.semcdb.2013.04.003","article-title":"Making connections in the inner ear: Recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells","volume":"24","author":"TM Coate","year":"2013","journal-title":"Semin Cell Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ydbio.2008.07.011","article-title":"Spatial and temporal segregation of auditory and vestibular neurons in the otic placode","volume":"322","author":"D Bell","year":"2008","journal-title":"Dev Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.pneurobio.2011.01.004","article-title":"Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly","volume":"93","author":"JM Appler","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1387\/ijdb.072373hs","article-title":"A network of growth and transcription factors controls neuronal differentiation and survival in the developing ear","volume":"51","author":"H Sanchez-Calderon","year":"2007","journal-title":"Int J Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e30790","DOI":"10.1371\/journal.pone.0030790","article-title":"AKT signaling mediates IGF-I survival actions on otic neural progenitors","volume":"7","author":"MR Aburto","year":"2012","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0378-5955(02)00447-1","article-title":"Cochlear abnormalities in insulin-like growth factor-1 mouse mutants","volume":"170","author":"G Camarero","year":"2002","journal-title":"Hear Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/978-0-387-76715-4_9","article-title":"The Hedgehog, TGF-beta\/BMP and Wnt families of morphogens in axon guidance","volume":"621","author":"F Charron","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"ref8","volume":"4","unstructured":"Salinas PC (2012) Wnt signaling in the vertebrate central nervous system: from axon guidance to synaptic function. Cold Spring Harb Perspect Biol <volume>4<\/volume>.."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.heares.2011.03.002","article-title":"The molecular basis of making spiral ganglion neurons and connecting them to hair cells of the organ of Corti","volume":"278","author":"T Yang","year":"2011","journal-title":"Hear Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1523\/JNEUROSCI.4703-12.2013","article-title":"Gata3 is a critical regulator of cochlear wiring","volume":"33","author":"JM Appler","year":"2013","journal-title":"J Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1073\/pnas.95.23.13513","article-title":"The lipid phosphatase activity of PTEN is critical for its tumor supressor function","volume":"95","author":"MP Myers","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.96.8.4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase\/AKT pathway","volume":"96","author":"LC Cantley","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1126\/science.1065518","article-title":"Negative regulation of neural stem\/progenitor cell proliferation by the Pten tumor suppressor gene in vivo","volume":"294","author":"M Groszer","year":"2001","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/mcne.2002.1115","article-title":"PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation","volume":"20","author":"L Li","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e55609","DOI":"10.1371\/journal.pone.0055609","article-title":"Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development","volume":"8","author":"HJ Kim","year":"2013","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000337229","article-title":"Development and characterization of NEX- Pten, a novel forebrain excitatory neuron-specific knockout mouse","volume":"34","author":"TM Kazdoba","year":"2012","journal-title":"Dev Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1242\/dev.129.14.3513","article-title":"PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum","volume":"129","author":"S Marino","year":"2002","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"10903","DOI":"10.1523\/JNEUROSCI.2358-11.2011","article-title":"Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly","volume":"31","author":"CC Lu","year":"2011","journal-title":"J Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e8699","DOI":"10.1371\/journal.pone.0008699","article-title":"RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors","volume":"5","author":"H Sanchez-Calderon","year":"2010","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e7144","DOI":"10.1371\/journal.pone.0007144","article-title":"Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear","volume":"4","author":"M Milo","year":"2009","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Dudoit S, Gentleman RC, Quackenbush J (2003) Open source software for the analysis of microarray data. Biotechniques Suppl: 45\u201351.","DOI":"10.2144\/mar03dudoit"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1523\/JNEUROSCI.18-09-03327.1998","article-title":"Development of the mouse inner ear and origin of its sensory organs","volume":"18","author":"H Morsli","year":"1998","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-physiol-012110-142228","article-title":"How the genetics of deafness illuminates auditory physiology","volume":"73","author":"GP Richardson","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lee K, Chiu I, Santos-Cortez R, Basit S, Khan S, <etal>et al<\/etal>.. (2012) Novel OTOA mutations cause autosomal recessive non-syndromic hearing impairment in Pakistani families. Clin Genet.","DOI":"10.1111\/cge.12047"},{"key":"ref27","first-page":"e535","article-title":"A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family","volume":"54","author":"M Ben Said","year":"2011","journal-title":"Eur J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.1073\/pnas.082515999","article-title":"Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22","volume":"99","author":"I Zwaenepoel","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.1210159109","article-title":"A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation","volume":"109","author":"AN Lukashkin","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ncomms1094","article-title":"Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice","volume":"1","author":"R Ghaffari","year":"2010","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nn1828","article-title":"Sharpened cochlear tuning in a mouse with a genetically modified tectorial membrane","volume":"10","author":"IJ Russell","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1242\/dev.128.13.2421","article-title":"Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons","volume":"128","author":"EJ Huang","year":"2001","journal-title":"Development"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s007950000001","article-title":"Role of osteopontin in the rodent inner ear as revealed by in situ hybridization","volume":"33","author":"M Sakagami","year":"2000","journal-title":"Med Electron Microsc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1749-6632.1995.tb44638.x","article-title":"Expression of osteopontin in the inner ear","volume":"760","author":"RL Davis","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3233\/JAD-2010-1309","article-title":"Osteopontin is increased in the cerebrospinal fluid of patients with Alzheimer&apos;s disease and its levels correlate with cognitive decline","volume":"19","author":"C Comi","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainres.2006.08.036","article-title":"Osteopontin expression in substantia nigra in MPTP-treated primates and in Parkinson&apos;s disease","volume":"1118","author":"J Iczkiewicz","year":"2006","journal-title":"Brain Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nbd.2006.10.020","article-title":"Osteopontin is elevated in Parkinson&apos;s disease and its absence leads to reduced neurodegeneration in the MPTP model","volume":"25","author":"W Maetzler","year":"2007","journal-title":"Neurobiol Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1096\/fj.04-1777fje","article-title":"Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth","volume":"19","author":"P Kury","year":"2005","journal-title":"Faseb j"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0076-6879(04)89005-0","article-title":"Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling","volume":"389","author":"MD Hains","year":"2004","journal-title":"Methods Enzymol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nn1700","article-title":"RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion","volume":"9","author":"J Ding","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"10613","DOI":"10.1523\/JNEUROSCI.23-33-10613.2003","article-title":"Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b","volume":"23","author":"N Grillet","year":"2003","journal-title":"J Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1128\/MCB.25.10.4221-4228.2005","article-title":"Generation and characterization of Rgs4 mutant mice","volume":"25","author":"N Grillet","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/carcin\/bgi352","article-title":"Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells","volume":"27","author":"Z Mi","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/15216540500159424","article-title":"Osteopontin: it&apos;s role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression","volume":"57","author":"R Das","year":"2005","journal-title":"IUBMB Life"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jss.2004.03.028","article-title":"The role of Osteopontin in tumor metastasis","volume":"121","author":"PY Wai","year":"2004","journal-title":"J Surg Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuint.2009.08.007","article-title":"Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia","volume":"55","author":"YP Yan","year":"2009","journal-title":"Neurochem Int"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.lungcan.2008.09.003","article-title":"Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin\/FAK\/Akt and NF-kappaB-dependent pathway","volume":"64","author":"YC Fong","year":"2009","journal-title":"Lung Cancer"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"28700","DOI":"10.1074\/jbc.273.44.28700","article-title":"Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways","volume":"273","author":"H Katoh","year":"1998","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00018-012-1178-z","article-title":"Zebrafish rgs4 is essential for motility and axonogenesis mediated by Akt signaling","volume":"70","author":"YC Cheng","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1523\/JNEUROSCI.22-11-04499.2002","article-title":"Altered levels of Gq activity modulate axonal pathfinding in <italic>Drosophila<\/italic>","volume":"22","author":"A Ratnaparkhi","year":"2002","journal-title":"J Neurosci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fncel.2013.00086","article-title":"Sonic hedgehog and Wnt: antagonists in morphogenesis but collaborators in axon guidance","volume":"7","author":"EC Aviles","year":"2013","journal-title":"Front Cell Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.neuroscience.2009.08.049","article-title":"Expression of Wnt receptors in adult spiral ganglion neurons: frizzled 9 localization at growth cones of regenerating neurites","volume":"164","author":"SM Shah","year":"2009","journal-title":"Neuroscience"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dvdy.22127","article-title":"Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect","volume":"239","author":"S Stuebner","year":"2010","journal-title":"Dev Dyn"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T08:43:06Z","timestamp":1716799386000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097544"}},"subtitle":[],"editor":[{"given":"Berta","family":"Alsina","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,3]]},"references-count":53,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097544","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,3]]}}}