{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:13:14Z","timestamp":1773695594942,"version":"3.50.1"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097555","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T20:27:10Z","timestamp":1400531230000},"page":"e97555","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of a Prednisolone Acetate-Loaded Subconjunctival Implant for the Treatment of Recurrent Uveitis in a Rabbit Model"],"prefix":"10.1371","volume":"9","author":[{"given":"Marcus","family":"Ang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwen","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheewai","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Phaik","family":"Chee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subbu S.","family":"Venkatraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina T.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0420.1997.tb00255.x","article-title":"Incidence and prevalence of different uveitis entities in Finland","volume":"75","author":"T Paivonsalo-Hietanen","year":"1997","journal-title":"Acta Ophthalmol Scand"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/bjo.84.7.706","article-title":"Population based assessment of uveitis in an urban population in southern India","volume":"84","author":"L Dandona","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/archopht.1969.00990020261021","article-title":"Radioactive depot-corticosteroid penetration into monkey ocular tissue. II. Subconjunctival administration","volume":"82","author":"RA Hyndiuk","year":"1969","journal-title":"Arch Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1167\/iovs.10-5285","article-title":"Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant","volume":"52","author":"JE Chang-Lin","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/bjo.2008.154906","article-title":"Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance","volume":"93","author":"MA Awan","year":"2009","journal-title":"Br J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3109\/02713683.2011.627489","article-title":"Evaluation of sustained release of PLC-loaded prednisolone acetate microfilm on postoperative inflammation in an experimental model of glaucoma filtration surgery","volume":"36","author":"M Ang","year":"2011","journal-title":"Curr Eye Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e70419","DOI":"10.1371\/journal.pone.0070419","article-title":"A biodegradable, sustained-released, prednisolone acetate microfilm drug delivery system effectively prolongs corneal allograft survival in the rat keratoplasty model","volume":"8","author":"YC Liu","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1167\/iovs.12-11466","article-title":"Optimization of subconjunctival biodegradable microfilms for sustained drug delivery to the anterior segment in a small animal model","volume":"54","author":"YC Liu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e22507","DOI":"10.1371\/journal.pone.0022507","article-title":"Biocompatibility and biodegradation studies of subconjunctival implants in rabbit eyes","volume":"6","author":"Y Peng","year":"2011","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ejpb.2008.05.024","article-title":"Modeling of drug release from biodegradable polymer blends","volume":"70","author":"LL Lao","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1167\/iovs.10-5939","article-title":"Treatment of experimental anterior and intermediate uveitis by a dexamethasone intravitreal implant","volume":"52","author":"CR Ghosn","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0161-6420(85)34001-0","article-title":"Standardization of vitreal inflammatory activity in intermediate and posterior uveitis","volume":"92","author":"RB Nussenblatt","year":"1985","journal-title":"Ophthalmology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0002-9394(14)74235-7","article-title":"International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease","volume":"103","author":"E Bloch-Michel","year":"1987","journal-title":"Am J Ophthalmol"},{"key":"ref14","first-page":"442","article-title":"Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis","volume":"36","author":"CK Cheng","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","first-page":"317","article-title":"Sustained release intraocular drug delivery devices for treatment of uveitis","volume":"6","author":"N Haghjou","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1444-0938.2006.00128.x","article-title":"Acute anterior uveitis in primary care","volume":"90","author":"IF Gutteridge","year":"2007","journal-title":"Clinical and Experimental Optometry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1517\/13543784.2011.617741","article-title":"Road to remission: a comprehensive review of therapy in uveitis","volume":"20","author":"SS Siddique","year":"2011","journal-title":"Expert Opin Investig Drugs"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archophthalmol.2010.339","article-title":"Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis","volume":"129","author":"C Lowder","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijpharm.2012.12.033","article-title":"A new drug delivery system inhibits uveitis in an animal model after cataract surgery","volume":"443","author":"S Eperon","year":"2013","journal-title":"Int J Pharm"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0105658","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:54:41Z","timestamp":1589025281000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097555"}},"subtitle":[],"editor":[{"given":"James T.","family":"Rosenbaum","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097555","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0105658","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]}}}