{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:43:47Z","timestamp":1793108627598,"version":"4.5.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097646","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T20:37:38Z","timestamp":1400099858000},"page":"e97646","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Metabolic Syndrome, Alcohol Consumption and Genetic Factors Are Associated with Serum Uric Acid Concentration"],"prefix":"10.1371","volume":"9","author":[{"given":"Blanka","family":"Stib\u016frkov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"Pavl\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitka","family":"Sokolov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Ko\u017eich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-7075-1-10","article-title":"Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle","volume":"1","author":"MR Hayden","year":"2004","journal-title":"Nutr Metab (Lond)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.3949\/ccjm.73.12.1059","article-title":"Role of uric acid in hypertension, renal disease, and metabolic syndrome","volume":"73","author":"M Heinig","year":"2006","journal-title":"Cleve Clin J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.amjhyper.2006.02.014","article-title":"Serum uric acid is a determinant of metabolic syndrome in a population-based study","volume":"19","author":"A Onat","year":"2006","journal-title":"Am J Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.atherosclerosis.2011.11.014","article-title":"Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study","volume":"220","author":"T Yang","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/hmg\/ddq097","article-title":"Variation in the uric acid transporter gene (SLC2A9) and memory performance","volume":"19","author":"LM Houlihan","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/oxfordjournals.aje.a008954","article-title":"Observations on serum uric acid levels and the risk of idiopathic Parkinson&apos;s disease","volume":"144","author":"JW Davis","year":"1996","journal-title":"Am J Epidemiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/art.24193","article-title":"Gout and the risk of Parkinson&apos;s disease: a cohort study","volume":"59","author":"M De Vera","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0954-6820.1974.tb00974.x","article-title":"Serum uric acid levels in women. An epidemiological survey with special reference to women with high serum uric acid values","volume":"196","author":"C Bengtsson","year":"1974","journal-title":"Acta Med Scand"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0026-0495(98)90056-7","article-title":"The effect of menopause on serum uric acid levels in non-obese healthy women","volume":"47","author":"CS Wingrove","year":"1998","journal-title":"Metabolism"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1047-2797(97)00204-4","article-title":"Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study. Coronary Artery Risk Development in Young Adults","volume":"8","author":"W Rathmann","year":"1998","journal-title":"Ann Epidemiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e37180","DOI":"10.1371\/journal.pone.0037180","article-title":"Uric acid is more strongly associated with impaired glucose regulation in women than in men from the general population: the KORA F4-Study","volume":"7","author":"C Meisinger","year":"2012","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.2337\/diabetes.52.11.2840","article-title":"Linkage analysis of a composite factor for the multiple metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study","volume":"52","author":"W Tang","year":"2003","journal-title":"Diabetes"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s004390051050","article-title":"Segregation analysis of serum uric acid in the NHLBI Family Heart Study","volume":"106","author":"JB Wilk","year":"2000","journal-title":"Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1681\/ASN.2007040426","article-title":"Genome scan for determinants of serum uric acid variability","volume":"18","author":"SD Nath","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.metabol.2005.05.007","article-title":"Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study","volume":"54","author":"Q Yang","year":"2005","journal-title":"Metabolism"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1056\/NEJM198212233072602","article-title":"Ethanol-induced hyperuricemia: evidence for increased urate production by activation of adenine nucleotide turnover","volume":"307","author":"J Faller","year":"1982","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1172\/JCI111512","article-title":"Ethanol-induced activation of adenine nucleotide turnover. Evidence for a role of acetate","volume":"74","author":"JG Puig","year":"1984","journal-title":"J Clin Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.numecd.2011.01.003","article-title":"Alcohol intake and the risk of hyperuricaemia: a 6-year prospective study in Japanese men","volume":"22","author":"K Nakamura","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels","volume":"417","author":"A Enomoto","year":"2002","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/ejhg.2013.3","article-title":"Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia: biochemical, genetics and functional analysis","volume":"21","author":"B Stiburkova","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.ASN.0000105320.04395.D0","article-title":"Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion","volume":"15","author":"K Ichida","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.107","article-title":"SLC2A9 influences uric acid concentrations with pronounced sex-specific effects","volume":"40","author":"A Doring","year":"2008","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout","volume":"40","author":"V Vitart","year":"2008","journal-title":"Nat Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1371\/journal.pmed.0050197","article-title":"SLC2A9 is a high-capacity urate transporter in humans","volume":"5","author":"MJ Caulfield","year":"2008","journal-title":"PLoS Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ajhg.2008.11.001","article-title":"Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia","volume":"83","author":"H Matsuo","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ymgme.2010.12.016","article-title":"Novel homozygous insertion in SLC2A9 gene caused renal hypouricemia","volume":"102","author":"B Stiburkova","year":"2011","journal-title":"Mol Genet Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00467-012-2174-0","article-title":"Acute kidney injury in two children caused by renal hypouricaemia type 2","volume":"27","author":"B Stiburkova","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1073\/pnas.0901249106","article-title":"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout","volume":"106","author":"OM Woodward","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.numecd.2006.02.002","article-title":"Association of methylenetetrahydrofolate reductase (C677T) polymorphism with hyperuricemia","volume":"17","author":"J Golbahar","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3346\/jkms.2004.19.2.209","article-title":"The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men","volume":"19","author":"YS Hong","year":"2004","journal-title":"J Korean Med Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.nutres.2009.10.006","article-title":"Significant association between methylenetetrahydrofolate reductase 677T allele and hyperuricemia among adult Japanese subjects","volume":"29","author":"S Itou","year":"2009","journal-title":"Nutr Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s100380070037","article-title":"The C677T mutation in the methylene tetrahydrofolate reductase gene increases serum uric acid in elderly men","volume":"45","author":"M Zuo","year":"2000","journal-title":"J Hum Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0021-9150(98)00079-3","article-title":"Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease","volume":"139","author":"C Motti","year":"1998","journal-title":"Atherosclerosis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1096-7192(03)00079-9","article-title":"Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease","volume":"79","author":"B Janosikova","year":"2003","journal-title":"Mol Genet Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"KG Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome\u2014a new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"KG Alberti","year":"2006","journal-title":"Diabet Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/art.20821","article-title":"Beer, liquor, and wine consumption and serum uric acid level: the Third National Health and Nutrition Examination Survey","volume":"51","author":"HK Choi","year":"2004","journal-title":"Arthritis Rheum"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s100380170031","article-title":"An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis","volume":"46","author":"R Kawamoto","year":"2001","journal-title":"J Hum Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1253\/circj.70.83","article-title":"Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men","volume":"70","author":"H Lwin","year":"2006","journal-title":"Circ J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"A Dehghan","year":"2008","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1186\/ar3356","article-title":"The SLC2A9 nonsynonymous Arg265His variant and gout: evidence for a population-specific effect on severity","volume":"13","author":"JE Hollis-Moffatt","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/ard.2009.113357","article-title":"Associations of a non-synonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese subjects and Solomon Islanders","volume":"69","author":"HP Tu","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5ra11","DOI":"10.1126\/scitranslmed.3000237","article-title":"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population","volume":"1","author":"H Matsuo","year":"2009","journal-title":"Sci Transl Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/keq096","article-title":"The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people","volume":"49","author":"K Yamagishi","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/hmg\/ddq412","article-title":"A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample sets","volume":"19","author":"AJ Phipps-Green","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1469-1809.2011.00698.x","article-title":"Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia","volume":"76","author":"R Karns","year":"2012","journal-title":"Ann Hum Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/ard.2009.111096","article-title":"Association between GLUT9 and gout in Japanese men","volume":"69","author":"W Urano","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s10067-013-2339-7","article-title":"Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease","volume":"32","author":"A Onat","year":"2013","journal-title":"Clin Rheumatol"},{"key":"ref49","unstructured":"Alderman M (1999) Uric acid in hypertension and cardiovascular disease. Can J Cardiol 15 Suppl F: 20F\u201322F."},{"key":"ref50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF00266358","article-title":"Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects","volume":"42","author":"M Nakashima","year":"1992","journal-title":"Eur J Clin Pharmacol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1053\/j.ackd.2012.07.010","article-title":"Changes in serum urate and urate excretion with age","volume":"19","author":"B Stiburkova","year":"2012","journal-title":"Adv Chronic Kidney Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T13:14:51Z","timestamp":1565442891000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097646"}},"subtitle":[],"editor":[{"given":"Pedro A.","family":"Jose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097646","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}