{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:01:06Z","timestamp":1783548066704,"version":"3.55.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097692","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T20:28:55Z","timestamp":1400531335000},"page":"e97692","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Terminal Axonal Arborization and Synaptic Bouton Formation Critically Rely on Abp1 and the Arp2\/3 Complex"],"prefix":"10.1371","volume":"9","author":[{"given":"Nicole","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Qualmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Kessels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.neuro.28.061604.135751","article-title":"Homeostatic control of neural activity: from phenomenology to molecular design","volume":"29","author":"GW Davis","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuron.2009.06.021","article-title":"Activity-dependent regulation of synapses by retrograde messengers","volume":"63","author":"WG Regehr","year":"2009","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(06)75001-2","article-title":"Introduction on the use of the Drosophila embryonic\/larval neuromuscular junction as a model system to study synapse development and function, and a brief summary of pathfinding and target recognition","volume":"75","author":"C Ruiz-Ca\u00f1ada","year":"2006","journal-title":"Int Rev Neurobiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0896-6273(04)00016-9","article-title":"Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila","volume":"41","author":"IP Coyle","year":"2004","journal-title":"Neuron"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1523\/JNEUROSCI.0256-10.2010","article-title":"dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal","volume":"30","author":"M Nahm","year":"2010","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/416442a","article-title":"Rac GTPases control axon growth, guidance and branching","volume":"416","author":"J Ng","year":"2002","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2010.04.011","article-title":"Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons","volume":"66","author":"RW Ball","year":"2010","journal-title":"Neuron"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11111","DOI":"10.1523\/JNEUROSCI.0833-08.2008","article-title":"Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules","volume":"28","author":"C Pawson","year":"2008","journal-title":"J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.devcel.2004.07.024","article-title":"Lamellipodin, an Ena\/VASP ligand, is implicated in the regulation of lamellipodial dynamics","volume":"7","author":"M Krause","year":"2004","journal-title":"Dev Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1083\/jcb.201110127","article-title":"Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton","volume":"197","author":"AK Stavoe","year":"2012","journal-title":"J Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1601-183X.2012.00822.x","article-title":"Ras-dependent and Ras-independent effects of PI3K in Drosophila motor neurons","volume":"11","author":"C Johnson","year":"2012","journal-title":"Genes Brain Behav"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1016\/S0960-9822(98)70051-X","article-title":"Axon guidance: GTPases help axons reach their targets","volume":"8","author":"G Gallo","year":"1998","journal-title":"Curr Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0896-6273(02)00752-3","article-title":"Raf and akt mediate distinct aspects of sensory axon growth","volume":"35","author":"A Markus","year":"2002","journal-title":"Neuron"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1091\/mbc.11.1.393","article-title":"Association of mouse actin-binding protein 1 (mAbp1\/SH3P7), an src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation","volume":"11","author":"MM Kessels","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1242\/jcs.101451","article-title":"Abp1 utilizes the Arp2\/3 complex activator Scar\/WAVE in bristle development","volume":"125","author":"N Koch","year":"2012","journal-title":"J Cell Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"17842","DOI":"10.1523\/JNEUROSCI.0843-12.2012","article-title":"The actin nucleator Cobl is crucial for Purkinje cell development and works in close conjunction with the F-actin binding protein Abp1","volume":"32","author":"N Haag","year":"2012","journal-title":"J Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.153.3.627","article-title":"Activation of the Arp2\/3 complex by the actin filament binding protein Abp1p","volume":"153","author":"BL Goode","year":"2001","journal-title":"J Cell Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e400","DOI":"10.1371\/journal.pone.0000400","article-title":"Regulation of N-WASP and the Arp2\/3 complex by Abp1 controls neuronal morphology","volume":"2","author":"R Pinyol","year":"2007","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13285","DOI":"10.1074\/jbc.M510226200","article-title":"Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization","volume":"281","author":"MM Kessels","year":"2006","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ncb1305","article-title":"Abi activates WASP to promote sensory organ development","volume":"10","author":"S Bogdan","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref21","unstructured":"Goldstein LSB, Fyrberg EA (1994) Drosophila melanogaster: Practical Uses in Cell and Molecular Biology. Academic Press."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1523\/JNEUROSCI.3160-06.2007","article-title":"Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin","volume":"27","author":"D Gorczyca","year":"2007","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1523\/JNEUROSCI.5479-03.2004","article-title":"Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP\/Shank family","volume":"24","author":"B Qualmann","year":"2004","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"20268","DOI":"10.1074\/jbc.M210792200","article-title":"Interactions between Piccolo and the actin\/dynaminbinding protein Abp1 link vesicle endocytosis to presynaptic active zones","volume":"278","author":"SD Fenster","year":"2003","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1083\/jcb.153.2.351","article-title":"Mammalian Abp1, a signal-responsive F-actin-binding protein, links the actin cytoskeleton to endocytosis via the GTPase dynamin","volume":"153","author":"MM Kessels","year":"2001","journal-title":"J Cell Biol"},{"key":"ref26","first-page":"275","article-title":"Bruchpilot, a protein with homology to ELKS\/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron 49: 833\u201344","volume":"51","author":"DA Wagh","year":"2006","journal-title":"Erratum in: Neuron (2006)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.8310297","article-title":"Paralysis and early death in cysteine string protein mutants of Drosophila","volume":"263","author":"KE Zinsmaier","year":"1994","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.cub.2009.07.058","article-title":"Drosophila Cip4\/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR\/WAVE","volume":"19","author":"R Fricke","year":"2009","journal-title":"Curr Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0896-6273(00)81170-8","article-title":"Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth","volume":"26","author":"J Roos","year":"2000","journal-title":"Neuron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/dneu.20728","article-title":"A critical step for postsynaptic F-actin organization: regulation of Baz\/Par-3 localization by aPKC and PTEN","volume":"69","author":"P Ramachandran","year":"2009","journal-title":"Dev Neurobiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1523\/JNEUROSCI.0336-08.2008","article-title":"The actin-binding protein Abp1 controls dendritic spine morphology and is important for spine head and synapse formation","volume":"28","author":"A Haeckel","year":"2008","journal-title":"J Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0006-291X(02)02972-8","article-title":"Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference","volume":"301","author":"S Mise-Omata","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/sj.emboj.7601053","article-title":"SH3P7\/mAbp1 deficiency leads to tissue and behavioral abnormalities and impaired vesicle transport","volume":"25","author":"S Connert","year":"2006","journal-title":"EMBO J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cub.2006.02.058","article-title":"Altered synaptic development and active zone spacing in endocytosis mutants","volume":"16","author":"DK Dickman","year":"2006","journal-title":"Curr Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.conb.2007.01.001","article-title":"Synaptic development: insights from Drosophila","volume":"17","author":"CA Collins","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0092-8674(01)00579-7","article-title":"Remodeling of synaptic actin induced by photoconductive stimulation","volume":"107","author":"MA Colicos","year":"2001","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.1523\/JNEUROSCI.21-14-05169.2001","article-title":"Stages of synapse development defined by dependence on F-actin","volume":"21","author":"W Zhang","year":"2001","journal-title":"J Neurosci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nn1002","article-title":"Actin has a molecular scaffolding, not propulsive, role in presynaptic function","volume":"6","author":"S Sankaranarayanan","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"12449","DOI":"10.1523\/JNEUROSCI.1381-09.2009","article-title":"Rapid assembly of functional presynaptic boutons triggered by adhesive contacts","volume":"29","author":"AL Lucido","year":"2009","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"17379","DOI":"10.1073\/pnas.1001794107","article-title":"WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling","volume":"107","author":"TM Khuong","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1083\/jcb.200109057","article-title":"SCAR is a primary regulator of Arp2\/3-dependent morphological events in Drosophila","volume":"156","author":"JA Zallen","year":"2002","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ydbio.2004.07.009","article-title":"WAVE\/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity","volume":"274","author":"A Schenck","year":"2004","journal-title":"Dev Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1749-8104-2-18","article-title":"HSPC300 and its role in neuronal connectivity","volume":"2","author":"A Qurashi","year":"2007","journal-title":"Neural Dev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1003450","DOI":"10.1371\/journal.pgen.1003450","article-title":"Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly","volume":"9","author":"L Zhao","year":"2013","journal-title":"PLoS Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/dvdy.23742","article-title":"Developmental expression of Drosophila Wiskott-Aldrich Syndrome family proteins","volume":"241","author":"E Rodriguez-Mesa","year":"2012","journal-title":"Dev Dyn"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.201007095","article-title":"The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures","volume":"192","author":"M Hatan","year":"2011","journal-title":"J Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.152.1.1","article-title":"WASP, the <italic>Drosophila<\/italic> Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling","volume":"152","author":"S Ben-Yaacov","year":"2001","journal-title":"J Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/genetics\/153.1.135","article-title":"The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes","volume":"153","author":"AC Spradling","year":"1999","journal-title":"Genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nature05954","article-title":"A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila","volume":"448","author":"G Dietzl","year":"2007","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0960-9822(00)00696-5","article-title":"Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein","volume":"10","author":"U Thomas","year":"2000","journal-title":"Curr Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.modgep.2005.07.006","article-title":"The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain","volume":"6","author":"A Mahr","year":"2006","journal-title":"Gene Expr Patterns"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00427-001-0194-z","article-title":"Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases","volume":"211","author":"C Schulz","year":"2001","journal-title":"Dev Genes Evol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:18:47Z","timestamp":1649017127000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097692"}},"subtitle":[],"editor":[{"given":"Subhabrata","family":"Sanyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,19]]},"references-count":52,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097692","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,19]]}}}