{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:05:33Z","timestamp":1791115533982,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0097771","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T20:38:18Z","timestamp":1400099898000},"page":"e97771","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Identification of Heparin-Binding EGF-Like Growth Factor (HB-EGF) as a Biomarker for Lysophosphatidic Acid Receptor Type 1 (LPA1) Activation in Human Breast and Prostate Cancers"],"prefix":"10.1371","volume":"9","author":[{"given":"Marion","family":"David","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashish","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Mege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Descotes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Leblanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cl\u00e9zardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Peyruchaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.02419-05","article-title":"Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development","volume":"26","author":"LA van Meeteren","year":"2006","journal-title":"Mol Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuint.2006.09.008","article-title":"Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i\/o) pathway","volume":"50","author":"N Fukushima","year":"2007","journal-title":"Neurochem Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"25822","DOI":"10.1074\/jbc.M605142200","article-title":"Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid","volume":"281","author":"M Tanaka","year":"2006","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bone.2011.04.018","article-title":"Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass","volume":"49","author":"I Gennero","year":"2011","journal-title":"Bone"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, et al. (2014) Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem.","DOI":"10.1074\/jbc.M113.533232"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03505","article-title":"LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing","volume":"435","author":"X Ye","year":"2005","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ni1573","article-title":"Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs","volume":"9","author":"H Kanda","year":"2008","journal-title":"Nat Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2000.tb06532.x","article-title":"Development of our current understanding of bioactive lysophospholipids","volume":"905","author":"WH Moolenaar","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: subtypes and biological actions","volume":"50","author":"JW Choi","year":"2010","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1476-5381.2011.01622.x","article-title":"Insights into the pharmacological relevance of lysophospholipid receptors","volume":"165","author":"T Mutoh","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.coph.2008.11.010","article-title":"Lysophosphatidic acid (LPA) and its receptors","volume":"9","author":"K Noguchi","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Choi KU, Yun JS, Lee IH, Heo SC, Shin SH, et al. (2010) Lysophosphatidic acid-induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer. Int J Cancer.","DOI":"10.1002\/ijc.25341"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.1074\/jbc.273.14.7906","article-title":"Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid","volume":"273","author":"S An","year":"1998","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nm1685","article-title":"The lysophosphatidic acid receptor LPA(1) links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak","volume":"14","author":"AM Tager","year":"2008","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/art.37991","article-title":"Necessity of lysophosphatidic acid receptor 1 for development of arthritis","volume":"65","author":"Y Miyabe","year":"2013","journal-title":"Arthritis Rheum"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nm1060","article-title":"Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling","volume":"10","author":"M Inoue","year":"2004","journal-title":"Nat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ccr.2009.03.027","article-title":"Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases","volume":"15","author":"S Liu","year":"2009","journal-title":"Cancer Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"9643","DOI":"10.1073\/pnas.0600979103","article-title":"The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases","volume":"103","author":"A Boucharaba","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3892\/ijo.2011.1309","article-title":"Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis","volume":"40","author":"M David","year":"2012","journal-title":"Int J Oncol"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Marshall JC, Collins JW, Nakayama J, Horak CE, Liewehr DJ, et al. (2012) Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer. J Natl Cancer Inst.","DOI":"10.1093\/jnci\/djs319"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1124\/mol.64.4.994","article-title":"Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors","volume":"64","author":"H Ohta","year":"2003","journal-title":"Mol Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1124\/mol.60.6.1173","article-title":"Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1\/LPA3 receptor antagonist","volume":"60","author":"CE Heise","year":"2001","journal-title":"Mol Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/jnci\/djn378","article-title":"Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells","volume":"100","author":"S Yu","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1074\/jbc.M306662200","article-title":"Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells","volume":"279","author":"X Fang","year":"2004","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1681\/ASN.2007020196","article-title":"LPA1 receptor activation promotes renal interstitial fibrosis","volume":"18","author":"JP Pradere","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e19756","DOI":"10.1371\/journal.pone.0019756","article-title":"Mechanical tension increases CCN2\/CTGF expression and proliferation in gingival fibroblasts via a TGFbeta-dependent mechanism","volume":"6","author":"F Guo","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1359\/jbmr.2001.16.11.2027","article-title":"Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions","volume":"16","author":"O Peyruchaud","year":"2001","journal-title":"J Bone Miner Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1172\/JCI200422123","article-title":"Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer","volume":"114","author":"A Boucharaba","year":"2004","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"R Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"17634","DOI":"10.1074\/jbc.M313927200","article-title":"Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1","volume":"279","author":"K Hama","year":"2004","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"45826","DOI":"10.1074\/jbc.M309024200","article-title":"Angiostatin Inhibits Bone Metastasis Formation in Nude Mice through a Direct Anti-osteoclastic Activity","volume":"278","author":"O Peyruchaud","year":"2003","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1210\/en.2003-1350","article-title":"Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid","volume":"145","author":"S Sakamoto","year":"2004","journal-title":"Endocrinology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijmm.2007.06.001","article-title":"Bacteria induce CTGF and CYR61 expression in epithelial cells in a lysophosphatidic acid receptor-dependent manner","volume":"298","author":"N Wiedmaier","year":"2008","journal-title":"Int J Med Microbiol"},{"key":"ref34","first-page":"1515","article-title":"Effects of lysophosphatidic acid and its receptors LPA(1\/3) on radiation pneumonitis","volume":"24","author":"J Xue","year":"2010","journal-title":"Oncol Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"R1058","DOI":"10.1186\/bcr1343","article-title":"HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells","volume":"7","author":"CA Wilson","year":"2005","journal-title":"Breast Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/hep.22283","article-title":"Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer","volume":"47","author":"C Coulouarn","year":"2008","journal-title":"Hepatology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1091\/mbc.E04-08-0658","article-title":"TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition","volume":"16","author":"U Valcourt","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cellsig.2010.10.019","article-title":"Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway","volume":"23","author":"C Cabello-Verrugio","year":"2011","journal-title":"Cell Signal"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"30475","DOI":"10.1074\/jbc.M103673200","article-title":"A dual signaling cascade that regulates the ectodomain shedding of heparin-binding epidermal growth factor-like growth factor","volume":"276","author":"T Umata","year":"2001","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"19501","DOI":"10.1074\/jbc.M511224200","article-title":"Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase C{delta}, Lyn Kinase, and Matrix Metalloproteinases","volume":"281","author":"Y Zhao","year":"2006","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF03185929","article-title":"Altered food consumption in mice lacking lysophosphatidic acid receptor-1","volume":"65","author":"R Dusaulcy","year":"2009","journal-title":"J Physiol Biochem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1744-8069-4-6","article-title":"Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain","volume":"4","author":"M Inoue","year":"2008","journal-title":"Mol Pain"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0097771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T13:14:56Z","timestamp":1565442896000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0097771"}},"subtitle":[],"editor":[{"given":"Irina V.","family":"Lebedeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":42,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0097771","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}