{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:37:20Z","timestamp":1792715840046,"version":"4.5.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T00:00:00Z","timestamp":1400630400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098179","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T16:41:19Z","timestamp":1400690479000},"page":"e98179","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Nebivolol Protects against Myocardial Infarction Injury via Stimulation of Beta 3-Adrenergic Receptors and Nitric Oxide Signaling"],"prefix":"10.1371","volume":"9","author":[{"given":"Zheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingwei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taohong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.7326\/0003-4819-136-5-200203050-00005","article-title":"Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994","volume":"136","author":"VL Roger","year":"2002","journal-title":"Ann Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"IV14","DOI":"10.1161\/01.CIR.102.suppl_4.IV-14","article-title":"Congestive heart failure: fifty years of progress","volume":"102","author":"E Braunwald","year":"2000","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/01.CIR.0000068316.53218.49","article-title":"Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure","volume":"107","author":"S Reiken","year":"2003","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1139\/y06-033","article-title":"Beta3-adrenergic eNOS stimulation in left ventricular murine myocardium","volume":"84","author":"K Brixius","year":"2006","journal-title":"Can J Physiol Pharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0008-6363(03)00359-6","article-title":"beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor","volume":"59","author":"G Tavernier","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref6","first-page":"3219","article-title":"beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current","volume":"118","author":"VA Skeberdis","year":"2008","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.pharmthera.2005.12.002","article-title":"beta3-adrenoceptors in the cardiovascular system: putative roles in human pathologies","volume":"111","author":"B Rozec","year":"2006","journal-title":"Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.jacc.2011.12.046","article-title":"Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase","volume":"59","author":"X Niu","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1172\/JCI9323","article-title":"beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility","volume":"106","author":"P Varghese","year":"2000","journal-title":"J Clin Invest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.CIR.103.12.1649","article-title":"Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium","volume":"103","author":"S Moniotte","year":"2001","journal-title":"Circulation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5152\/akd.2010.006","article-title":"Nebivolol prevents remodeling in a rat myocardial infarction model: an echocardiographic study","volume":"10","author":"GO Mercanoglu","year":"2010","journal-title":"Anadolu Kardiyol Derg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ahj.2007.03.025","article-title":"Tolerability and dose-related effects of nebivolol in elderly patients with heart failure: data from the Study of the Effects of Nebivolol Intervention on Outcomes and Rehospitalisation in Seniors with Heart Failure (SENIORS) trial","volume":"154","author":"D Dobre","year":"2007","journal-title":"Am Heart J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/157489007780832588","article-title":"Nebivolol: more than a highly selective Beta blocker","volume":"2","author":"Y Karter","year":"2007","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/HYPERTENSIONAHA.107.094458","article-title":"Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation","volume":"50","author":"A Maffei","year":"2007","journal-title":"Hypertension"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00395-013-0333-5","article-title":"Rosuvastatin enhances the therapeutic efficacy of adipose-derived mesenchymal stem cells for myocardial infarction via PI3K\/Akt and MEK\/ERK pathways","volume":"108","author":"Z Zhang","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e33491","DOI":"10.1371\/journal.pone.0033491","article-title":"Luteolin limits infarct size and improves cardiac function after myocardium ischemia\/reperfusion injury in diabetic rats","volume":"7","author":"D Sun","year":"2012","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00011-010-0232-2","article-title":"Toll-like receptor 4 signaling in dysfunction of cardiac microvascular endothelial cells under hypoxia\/reoxygenation","volume":"60","author":"Z Zhang","year":"2011","journal-title":"Inflamm Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jacc.2010.09.037","article-title":"Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional beta1-blockade","volume":"57","author":"SA Sorrentino","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1016\/j.jacc.2011.09.033","article-title":"Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation","volume":"58","author":"JP Aragon","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref20","first-page":"905","article-title":"Place of beta 3-adrenoceptors among other beta-adrenoceptor subtypes in the regulation of the cardiovascular system","volume":"96","author":"B Rozec","year":"2003","journal-title":"Arch Mal Coeur Vaiss"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1172\/JCI118823","article-title":"Functional beta3-adrenoceptor in the human heart","volume":"98","author":"C Gauthier","year":"1996","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1172\/JCI2191","article-title":"The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle","volume":"102","author":"C Gauthier","year":"1998","journal-title":"J Clin Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"H2084","DOI":"10.1152\/ajpheart.00675.2001","article-title":"Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension","volume":"282","author":"Y Iwakiri","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cardiores.2006.02.002","article-title":"Are myocardial eNOS and nNOS involved in the beta-adrenergic and muscarinic regulation of inotropy? A systematic investigation","volume":"70","author":"SR Martin","year":"2006","journal-title":"Cardiovasc Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T13:00:38Z","timestamp":1540213238000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098179"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,21]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098179","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,21]]}}}