{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:37:22Z","timestamp":1790743042251,"version":"4.1.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T00:00:00Z","timestamp":1401148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098390","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T22:23:27Z","timestamp":1401229407000},"page":"e98390","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Anti-Inflammatory Effects of Rebamipide Eyedrop Administration on Ocular Lesions in a Murine Model of Primary Sj\u00f6gren's Syndrome"],"prefix":"10.1371","volume":"9","author":[{"given":"Rieko","family":"Arakaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasusei","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tserennadmid","family":"Enkhmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumika","family":"Hotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Mitamura-Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Mitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naozumi","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sjogren&apos;s syndrome","volume":"366","author":"RI Fox","year":"2005","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.berh.2012.01.012","article-title":"Sjogren&apos;s syndrome, the old and the new","volume":"26","author":"Y Peri","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/BOR.0b013e328363eaa5","article-title":"New advances in the classification, pathogenesis and treatment of Sjogren&apos;s syndrome","volume":"25","author":"CP Mavragani","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/art.23163","article-title":"Effective treatment with oral administration of rebamipide in a mouse model of Sjogren&apos;s syndrome","volume":"58","author":"M Kohashi","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1179\/135100006X155021","article-title":"Oxidative stress involvement and gene expression in indomethacin-induced gastropathy","volume":"11","author":"Y Naito","year":"2006","journal-title":"Redox Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s10620-008-0507-4","article-title":"Rebamipide, a cytoprotective drug, increases gastric mucus secretion in human: evaluations with endoscopic gastrin test","volume":"54","author":"K Iijima","year":"2009","journal-title":"Dig Dis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/bjophthalmol-2012-302868","article-title":"Rebamipide increases barrier function and attenuates TNFalpha-induced barrier disruption and cytokine expression in human corneal epithelial cells","volume":"97","author":"H Tanaka","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.lfs.2013.05.019","article-title":"The effect of polaprezinc on gastric mucosal protection in rats with ethanol-induced gastric mucosal damage: comparison study with rebamipide","volume":"93","author":"HS Choi","year":"2013","journal-title":"Life Sci"},{"key":"ref9","first-page":"75","article-title":"Anatomical aspects of the lacrimal gland of the tufted capuchin (Cebus apella)","volume":"180","author":"ER Veiga Neto","year":"1992","journal-title":"J Anat"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.4049\/jimmunol.153.6.2769","article-title":"A new animal model for primary Sjogren&apos;s syndrome in NFS\/sld mutant mice","volume":"153","author":"N Haneji","year":"1994","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.coph.2009.04.008","article-title":"Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity.","volume":"9","author":"S Sanjabi","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.coi.2003.09.004","article-title":"Negative regulation of cytokine signaling influences inflammation.","volume":"15","author":"A Yoshimura","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"ref13","first-page":"82","article-title":"Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium","volume":"41","author":"M Tei","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.exer.2011.12.010","article-title":"Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus","volume":"96","author":"SA Balasubramanian","year":"2012","journal-title":"Exp Eye Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.ophtha.2007.06.027","article-title":"Lactoferrin in Sj\u00f6gren&apos;s syndrome","volume":"114","author":"M Dogru","year":"2007","journal-title":"Ophthalmology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/jop.1998.14.99","article-title":"Lactoferrin suppresses loss of corneal epithelial integrity in a rabbit short-term dry eye model","volume":"14","author":"T Fujihara","year":"1998","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref17","first-page":"501","article-title":"Neural stimulation of lactoferrin and epidermal growth factor secretion by the lacrimal gland","volume":"16","author":"MB Goren","year":"1997","journal-title":"Cornea"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1586\/egh.10.25","article-title":"Rebamipide: a gastrointestinal protective drug with pleiotropic activities","volume":"4","author":"Y Naito","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/jop.2011.0147","article-title":"Rebamipide increases mucin-like substance contents and periodic acid Schiff reagent-positive cells density in normal rabbits","volume":"28","author":"H Urashima","year":"2012","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ajo.2013.11.010","article-title":"A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye","volume":"157","author":"S Kinoshita","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.276.5312.604","article-title":"Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren&apos;s syndrome","volume":"276","author":"N Haneji","year":"1997","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/978-1-4615-2417-5_104","article-title":"Murine models of Sj\u00f6gren&apos;s syndrome","volume":"350","author":"DA Jabs","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jaut.2009.09.009","article-title":"Sj\u00f6gren&apos;s syndrome: advances in the pathogenesis from animal models","volume":"33","author":"JA Chiorini","year":"2009","journal-title":"J Autoimmun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"549107","DOI":"10.1155\/2011\/549107","article-title":"Current concepts: mouse models of Sj\u00f6gren&apos;s syndrome","volume":"2011","author":"TN Lavoie","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.4049\/jimmunol.165.4.2251","article-title":"Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sj\u00f6gren&apos;s syndrome","volume":"165","author":"K Saegusa","year":"2000","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)65027-4","article-title":"Severe destructive autoimmune lesions with aging in murine Sj\u00f6gren&apos;s syndrome through Fas-mediated apoptosis","volume":"156","author":"N Ishimaru","year":"2000","journal-title":"Am J Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1172\/JCI0214682","article-title":"Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity","volume":"110","author":"K Saegusa","year":"2002","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9440(10)65111-5","article-title":"Estrogen deficiency acceletates autoimmune exocrinopathy in murine Sj\u00f6gren&apos;s syndrome through fas-mediated apoptosis","volume":"155","author":"N Ishimaru","year":"1999","journal-title":"Am J Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12016-011-8288-5","article-title":"Animal models in autoimmune diseases: lessons learned from mouse models for Sjogren&apos;s syndrome","volume":"42","author":"BH Lee","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/lary.20292","article-title":"The minor salivary gland biopsy as a diagnostic tool for Sjogren syndrome","volume":"119","author":"R Bamba","year":"2009","journal-title":"Laryngoscope"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1679\/aohc1950.44.299","article-title":"The mammalian Harderian gland: morphology, biochemistry, function and phylogeny","volume":"44","author":"T Sakai","year":"1981","journal-title":"Arch Histol Jpn"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000147222","article-title":"Secretion mode of the harderian gland of rats after stimulation by cholinergic secretagogues","volume":"143","author":"Y Satho","year":"1992","journal-title":"Acta Anat (Basel)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s004410050666","article-title":"Secrtetagogue-induced apocrine secretion in the Harderian gland of the rat","volume":"285","author":"AP Gesase","year":"1996","journal-title":"Cell Tissue Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00535-010-0271-z","article-title":"Lactoferrin targets T cells in the small intestine","volume":"45","author":"SM Nielsen","year":"2010","journal-title":"J Gastroenterol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e33148","DOI":"10.1371\/journal.pone.0033148","article-title":"Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice","volume":"7","author":"M Kawashima","year":"2012","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0002-9394(14)77735-9","article-title":"Penetration routs of topically applied eye medications","volume":"85","author":"MG Doane","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1084\/jem.20080174","article-title":"Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sj\u00f6gren&apos;s syndrome-like autoimmune exocrinopathy","volume":"205","author":"N Ishimaru","year":"2008","journal-title":"J Exp Med"},{"key":"ref38","first-page":"101","article-title":"Improvement of lacrimal function by topical application of CyA in murine models of Sj\u00f6gren&apos;s syndrome","volume":"42","author":"K Tsubota","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/ICO.0b013e31823f0a64","article-title":"Effects of topical human amniotic fluid and human serum in a mouse model of keratoconjunctivitis sicca","volume":"31","author":"GG Quinto","year":"2012","journal-title":"Cornea"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.4049\/jimmunol.0802289","article-title":"Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin causes autoimmunity due to the disruption of T cell tolerance","volume":"182","author":"N Ishimaru","year":"2009","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T18:29:53Z","timestamp":1689272993000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098390"}},"subtitle":[],"editor":[{"given":"John A.","family":"Chiorini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,27]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098390","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,27]]}}}