{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:42:18Z","timestamp":1769600538860,"version":"3.49.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098426","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T23:57:50Z","timestamp":1402444670000},"page":"e98426","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Changes in QTc Interval in the Citalopram for Agitation in Alzheimer's Disease (CitAD) Randomized Trial"],"prefix":"10.1371","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct00898807","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Lea T.","family":"Drye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Spragg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Devanand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine","family":"Frangakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Marano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis L.","family":"Meinert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobo E.","family":"Mintzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A.","family":"Munro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Pelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce G.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton P.","family":"Porsteinsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter V.","family":"Rabins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul B.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lon S.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Shade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Yesavage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantine G.","family":"Lyketsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the CitAD Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1213\/ane.0b013e31816ba463","article-title":"Pro: The Food and Drug Administration Black box warning on droperidol is not justified","volume":"106","author":"AS Habib","year":"2008","journal-title":"Anesth Analg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jelectrocard.2004.08.030","article-title":"A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs","volume":"37","author":"S Luo","year":"2004","journal-title":"J Electrocardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1540-8167.2006.00408.x","article-title":"QT interval: how to measure it and what is \u201cnormal\u201d","volume":"17","author":"I Goldenberg","year":"2006","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/heart.89.11.1363","article-title":"Drug induced QT prolongation and torsades de pointes","volume":"89","author":"YG Yap","year":"2003","journal-title":"Heart"},{"key":"ref5","first-page":"2120","article-title":"What clinicians should know about the QT interval","volume":"289","author":"SM Al-Khatib","year":"2003","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archinte.164.9.943","article-title":"Prolonged QTc interval and risks of total and cardiovascular mortality and sudden death in the general population: a review and qualitative overview of the prospective cohort studies","volume":"164","author":"A Montanez","year":"2004","journal-title":"Arch Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/EDE.0b013e318225768b","article-title":"Electrocardiographic QT interval and mortality: a meta-analysis","volume":"22","author":"Y Zhang","year":"2011","journal-title":"Epidemiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1566","DOI":"10.1136\/bmj.e1566","article-title":"Discontinuation of antidepressants in people with dementia and neuropsychiatric symptoms (DESEP study): double blind, randomised, parallel group, placebo controlled trial","volume":"344","author":"S Bergh","year":"2012","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"d4551","DOI":"10.1136\/bmj.d4551","article-title":"Antidepressant use and risk of adverse outcomes in older people: population based cohort study","volume":"343","author":"C Coupland","year":"2011","journal-title":"BMJ"},{"key":"ref10","article-title":"FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide)","year":"2011"},{"key":"ref11","article-title":"Pharmacovigilance Working Party (PhVWP) October 2011 plenary meeting","year":"2011"},{"key":"ref12","article-title":"Report from the CMDh meeting held on 17th, 18th and 19th October 2011","year":"2011"},{"key":"ref13","article-title":"Drug Safety Update","year":"2011"},{"key":"ref14","article-title":"FDA Drug Safety Communication: Revised recommendations for Celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses","year":"2012"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"f288","DOI":"10.1136\/bmj.f288","article-title":"QT interval and antidepressant use: a cross sectional study of electronic health records","volume":"346","author":"VM Castro","year":"2013","journal-title":"BMJ"},{"key":"ref16","article-title":"Evaluation of the FDA Warning Against Prescribing Citalopram at Doses Exceeding 40 mg","author":"K Zivin","year":"2013","journal-title":"Am J Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"G McKhann","year":"1984","journal-title":"Neurology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-Mental State\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jalz.2011.01.007","article-title":"Citalopram for agitation in Alzheimer's disease: design and methods","volume":"8","author":"LT Drye","year":"2012","journal-title":"Alzheimers Dement"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/jama.2014.93","article-title":"Effect of Citalopram on Agitation in Alzheimer's Disease \u2013 The CitAD Randomized Controlled Trial","volume":"311","author":"AP Porsteinsson","year":"2014","journal-title":"JAMA"},{"key":"ref21","article-title":"Points to consider: The assessment of the potential for QT interval prolongation by non-cardiovascular medicinal products. CPMP\/986\/96","year":"1997"},{"key":"ref22","article-title":"Guidance for Industry: E14 Clinical Evaluation of QT\/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs","year":"2005"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1542-474X.2001.tb00097.x","article-title":"An evaluation of the impact of gender and age on QT dispersion in healthy subjects","volume":"6","author":"H Tran","year":"2001","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/ageing\/32.3.326","article-title":"Impact of age on QT interval and QT dispersion in healthy subjects: a regression analysis","volume":"32","author":"AA Mangoni","year":"2003","journal-title":"Age Ageing"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ahj.2012.05.024","article-title":"Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: results from the Duke Databank for Cardiovascular Disease (DDCD)","volume":"164","author":"ES Williams","year":"2012","journal-title":"Am Heart J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/clc.4960191209","article-title":"QT interval change with age in an overtly healthy older population","volume":"19","author":"M Reardon","year":"1996","journal-title":"Clin Cardiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1177\/0091270004269647","article-title":"Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects","volume":"44","author":"RR Bies","year":"2004","journal-title":"J Clin Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/01.jcp.0000104913.75206.62","article-title":"A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition","volume":"24","author":"EP Harrigan","year":"2004","journal-title":"J Clin Psychopharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1177\/026988110101500212","article-title":"Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine","volume":"15","author":"LV Wilton","year":"2001","journal-title":"J Psychopharmacol"},{"key":"ref30","article-title":"Patient Information UROXATRAL (Alfuzosin hydrochloride extended-release tablets)","year":"2009"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:45:37Z","timestamp":1540219537000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098426"}},"subtitle":[],"editor":[{"given":"T. Mark","family":"Doherty","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098426","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,10]]}}}