{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:15:37Z","timestamp":1767179737950,"version":"build-2238731810"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098642","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T16:28:48Z","timestamp":1402072128000},"page":"e98642","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical Impact of De-Regulated Notch-1 and Notch-3 in the Development and Progression of HPV-Associated Different Histological Subtypes of Precancerous and Cancerous Lesions of Human Uterine Cervix"],"prefix":"10.1371","volume":"9","author":[{"given":"Richa","family":"Tripathi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayatri","family":"Rath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Jawanjal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pallavi","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Bhambhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Showket","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mausumi","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1016\/j.vaccine.2008.03.056","article-title":"Prospects and prejudices of human papillomavirus vaccines in India","volume":"26","author":"BC Das","year":"2008","journal-title":"Vaccine"},{"key":"ref2","unstructured":"Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, <etal>et al<\/etal>.. (2013). Globacan 2012, 1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No.11."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ygyno.2012.11.041","article-title":"Down-regulation of tumor suppressor gene PML in uterine cervical carcinogenesis: Impact of human papillomavirus infection (HPV)","volume":"28(3)","author":"N Singh","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/aje\/kwg171","article-title":"HPV Study Group: Determinants of clearance of human papillomavirus infections in Colombian women with normal cytology: a population-based, 5-year follow-up study","volume":"158","author":"M Molano","year":"2003","journal-title":"Am? J? Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch: cell fate control and signal integration in development","volume":"284","author":"TS Artavanis","year":"1999","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1371\/journal.pbio.0030096","article-title":"Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate in Drosophila","volume":"3","author":"R Le Borgne","year":"2005","journal-title":"PLoS Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/mcne.1997.0612","article-title":"The ins and outs of Notch","volume":"9(2)","author":"G Weinmaster","year":"1997","journal-title":"Mol Cell Neuroscience"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/156800906777441771","article-title":"Notch as a novel cancer therapeutic target","volume":"6","author":"L Miele","year":"2006","journal-title":"Curr Cancer Drug Targets"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.2217\/fmb.12.95","article-title":"Instigation of Notch in the pathogenesis of Kaposi&apos;s sarcoma-associated herpes virus and other human tumor viruses","volume":"7(10)","author":"F Cheng","year":"2012","journal-title":"Future Microbiol"},{"key":"ref10","first-page":"163","article-title":"Recent advances on Notch in T-ALL","volume":"360","author":"G Tzoneva","year":"2012","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/carcin\/bgq066","article-title":"MicroRNA-34a suppresses invasion through downregulation of Notch-1 and Jagged-1 in cervical carcinoma and choriocarcinoma cells","volume":"31(6)","author":"RT Pang","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/bcr559","article-title":"Is there a role for Notch signalling in human breast cancer?","volume":"5(2)","author":"K Brennan","year":"2003","journal-title":"Breast Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1182\/blood-2005-08-3329","article-title":"Recent insights into the role of Notch in tumorigenesis","volume":"107(6)","author":"KG Leong","year":"2006","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1158\/0008-5472.CAN-07-1597","article-title":"Notch-3 pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells","volume":"68","author":"N Yamaguchi","year":"2008","journal-title":"Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.1158\/0008-5472.CAN-08-0001","article-title":"Jagged-1 and Notch-3 juxtacrine loop regulates ovarian tumor growth and adhesion","volume":"68","author":"JH Choi","year":"2008","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1158\/0008-5472.CAN-10-2719","article-title":"Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer","volume":"(18)","author":"W Hu","year":"2011","journal-title":"Cancer Res 71"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ygyno.2010.03.004","article-title":"Expression of nuclear Notch-3 in cervical squamous cell carcinomas and its association with adverse clinical outcomes","volume":"117(3)","author":"S Yeasmin","year":"2010","journal-title":"Gynecol Oncol"},{"key":"ref18","first-page":"292","article-title":"The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma","volume":"18(4)","author":"AA Bahnassy","year":"2006","journal-title":"J? Egypt Natl Canc Inst"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1471-0528.1996.tb09764.x","article-title":"Cervical and vulva cancer: changes in FIGO definitions of staging","volume":"103","author":"JH Shepherd","year":"1996","journal-title":"Br? J? Obstet Gynaecol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e11939","DOI":"10.1371\/journal.pone.0011939","article-title":"Nuclear S100A7 is associated with poor prognosis in head and neck cancer","volume":"5(8)","author":"SC Tripathi","year":"2010","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/1471-2407-9-329","article-title":"Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human papillomavirus infection","volume":"9","author":"S Hussain","year":"2009","journal-title":"BMC Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s13402-011-0056-2","article-title":"Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis","volume":"34(6)","author":"RC Sobti","year":"2011","journal-title":"Cell Oncol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ygyno.2012.11.041","article-title":"Down-regulation of tumor suppressor gene PML in uterine cervical carcinogenesis: Impact of human papillomavirus infection (HPV)","volume":"128(3)","author":"N Singh","year":"2013","journal-title":"Gynecol Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/339237a0","article-title":"Avoiding false positives with PCR","volume":"339","author":"S Kwok","year":"1989","journal-title":"Nature"},{"key":"ref25","unstructured":"American Cancer Society (2012) Cancer Facts &amp; Figures. Atlanta, GA: American Cancer Society"},{"key":"ref26","first-page":"S2","article-title":"The Impact of Liquid-Based Cytology in Decreasing the Incidence of Cervical Cancer","volume":"(1)","author":"RK Gibb","year":"2011","journal-title":"Rev Obst & Gynecol 4"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/cncr.11208","article-title":"Progress in cancer screening practices in the United States. Results from the 2000 national health interview survey","volume":"97","author":"J Swan","year":"2003","journal-title":"Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.32398\/cjhp.v4i3.1966","article-title":"A needs assessment of barriers to cervical cancer screening in Vietnamese American health care providers","volume":"4","author":"TK Harry","year":"2006","journal-title":"Californian? J? Health Promotion"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1371\/journal.pmed.0050132","article-title":"Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities","volume":"5","author":"E Gakidou","year":"2008","journal-title":"PloS Med"},{"key":"ref30","first-page":"785","article-title":"Symptomatology of gynecological malignancies: experiences in the gynecology out-patient clinic of a tertiary care hospital in Kolkata, India","volume":"11","author":"M Sarkar","year":"2010","journal-title":"Asian Pac? J? Cancer Prev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.7314\/APJCP.2012.13.6.2997","article-title":"Gynecological malignancies: epidemiological characteristics of the patients in a tertiary care hospital in India","volume":"13","author":"M Sarkar","year":"2012","journal-title":"Asian Pac? J? Cancer Prev"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.7314\/APJCP.2013.14.6.3541","article-title":"Clinicopathological features of gynecological malignancies in a tertiary care hospital in eastern India: Importance of strengthening primary health care in prevention and early detection","volume":"(6)","author":"M Sarkar","year":"2013","journal-title":"Asian Pacific? J? Cancer Prev 14"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.7314\/APJCP.2013.14.6.3641","article-title":"Cervical Cancer Screening: Knowledge, Attitude and Practices among Nursing Staff in a Tertiary Level Teaching Institution of Rural India","volume":"Prev14(6)","author":"S Shekhar","year":"2013","journal-title":"Asian Pac? J? Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijgo.2008.12.010","article-title":"Evaluation of cervical screening in rural North India","volume":"105","author":"N Bhatla","year":"2009","journal-title":"Int? J? Gynaecol Obstet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"M Scheffner","year":"1990","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11010-009-0133-2","article-title":"Over-expression of STAT3 in HPV-mediated cervical cancer in a North Indian population","volume":"330(1-2)","author":"RC Sobti","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.vaccine.2006.05.031","article-title":"Epidemiology and transmission dynamics of genital HPV infection","volume":"(3)","author":"AN Burchell","year":"2006","journal-title":"Vaccine 24"},{"key":"ref38","first-page":"353","article-title":"Modern Approaches to Prevention and Control of Cancer of the Uterine Cervix in women Journal of the Indian Institute of Science 92","volume":"(3)","author":"S Gupta","year":"2012"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/PGP.0b013e31816085ba","article-title":"Human papillomavirus-type distribution in women with and without cervical neoplasia in north India","volume":"27(3)","author":"N Bhatla","year":"2008","journal-title":"Int? J? Gynecol Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jmv.22261","article-title":"Human papillomavirus infection among young adolescents in India: Impact of vaccination","volume":"84(2)","author":"S Hussain","year":"2012","journal-title":"J? Med Virol"},{"key":"ref41","first-page":"55","article-title":"Papillomavirus infections: a major cause of human cancers","volume":"1288","author":"HZ Hausen","year":"1996","journal-title":"Biochem Biophys Acta"},{"key":"ref42","first-page":"249","article-title":"TNF-308G\/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population","volume":"29","author":"I Kohaar","year":"2007","journal-title":"Cell Oncol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/ijc.11350","article-title":"Human papillomavirus and risk factors for cervical cancer in Chennai, India: A case-control study","volume":"(1)","author":"S Franceschi","year":"2003","journal-title":"Int? J? Cancer 107"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.soc.2013.11.004","article-title":"Systemic and Targeted Therapy for Biliary Tract Tumors and Primary Liver Tumors","volume":"23(2)","author":"MB Thomas","year":"2014","journal-title":"Surg Oncol Clin? N? Am"},{"key":"ref45","first-page":"667","article-title":"Role of Notch signalling pathway in cancer and its association with DNA methylation","volume":"2(3)","author":"MG Aithal","year":"2013","journal-title":"Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.5858\/2009-0582-RAR1.1","article-title":"The Immunohistochemistry laboratory: looking at molecules and preparing for tomorrow","volume":"134(11)","author":"J Teruya-Feldstein","year":"2010","journal-title":"Arch.Pathol Lab Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1101\/gad.988902","article-title":"Specific down-modulation of Notch1 signalling in cervical cancer cells is required for sustained HPV-E6\/E7 expression and late steps of malignant transformation","volume":"6","author":"C Talora","year":"2002","journal-title":"Genes Dev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/viro.2001.0867","article-title":"Rangarajan A, Syal R, Selvarajah S, Chakrabarti O, Sarin A, et al. 2001) Activated Notch-1 cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB\/Akt","volume":"286","journal-title":"Virology"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Bharadwaj M, Hussain S, Tripathi R, Singh N, Mehrotra R (2014) Human Papillomavirus (HPV): Diagnosis and Treatment. In Animal Biotechnology: Models in Discovery and Translation, Verma A and Singh A, editors. Elsevier. pp.95\u2013120","DOI":"10.1016\/B978-0-12-416002-6.00006-7"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.4161\/cc.22134","article-title":"Developmental pathways in colon cancer Crosstalk between WNT, BMP, Hedgehog and Notch","volume":"11(23)","author":"FE Bertrand","year":"2012","journal-title":"Cell Cycle"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0896-6273(01)00179-9","article-title":"Notch-1 and Notch-3 instructively restrict bFGF responsive multipotent neural progenitor cells to an astroglial fate","volume":"29","author":"K Tanigaki","year":"2001","journal-title":"Neuron"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2040-2384-2-3","article-title":"Notch regulates the angiogenic response via induction of VEGFR-1","volume":"2","author":"Y Funahashi","year":"2008","journal-title":"J? Angiogenes Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1158\/0008-5472.CAN-07-1022","article-title":"Gamma-secretase inhibitor prevents Notch-3 activation and reduces proliferation in human lung cancers","volume":"67","author":"J Konishi","year":"2007","journal-title":"Cancer Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1038\/sj.onc.1208783","article-title":"Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi&apos;s sarcoma tumor cells","volume":"24","author":"CL Curry","year":"2005","journal-title":"Oncogene"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature08543","article-title":"Direct inhibition of the Notch transcription factor complex","volume":"462","author":"RE Moellering","year":"2009","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"15161","DOI":"10.1523\/JNEUROSCI.4966-09.2009","article-title":"The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors","volume":"29","author":"B Kefas","year":"2009","journal-title":"J? Neurosci"},{"key":"ref57","first-page":"1921","article-title":"MicroRNA-206 targets Notch-3, activates apoptosis and inhibits tumor cell migration and focus formation","volume":"(3)","author":"G Song","year":"2009","journal-title":"J? Biol Chem 284"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Gilbert CA, Hermance N, Daou MC, <etal>et al<\/etal>.. (2010) Glioma treatment with temozolomide and Notch inhibition suppresses neurosphere formation and xenograft formation. AACR Meeting Abstracts.","DOI":"10.1158\/1538-7445.AM10-LB-32"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/stem.261","article-title":"Notch promotes radioresistance of glioma stem cells","volume":"28","author":"J Wang","year":"2010","journal-title":"Stem Cells"},{"key":"ref60","first-page":"127","article-title":"Mouse microRNA-124 regulates the expression of HES-1 in P19 cells","volume":"2","author":"C Wang","year":"2010","journal-title":"Front Biosci"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0272116","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"record-id":"38314"},{"DOI":"10.1371\/journal.pone.0272116","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:15:43Z","timestamp":1649243743000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098642"}},"subtitle":[],"editor":[{"given":"Ruby John","family":"Anto","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098642","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}