{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:13:37Z","timestamp":1789420417055,"version":"build-2803163510"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:00:00Z","timestamp":1401753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098658","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T20:31:26Z","timestamp":1401827486000},"page":"e98658","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["CMZ Reversed Chronic Ethanol-Induced Disturbance of PPAR-\u03b1 Possibly by Suppressing Oxidative Stress and PGC-1\u03b1 Acetylation, and Activating the MAPK and GSK3\u03b2 Pathway"],"prefix":"10.1371","volume":"9","author":[{"given":"Tao","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Lan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Qin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/10915810490502069","article-title":"Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis","volume":"23","author":"S Ramaiah","year":"2004","journal-title":"Int J Toxicol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"RS O'Shea","year":"2010","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/hep.510270601","article-title":"Hepatic steatosis: innocent bystander or guilty party?","volume":"27","author":"CP Day","year":"1998","journal-title":"Hepatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2302\/kjm.48.184","article-title":"Pathogenesis of alcoholic liver disease: newer mechanisms of injury","volume":"48","author":"DW Crabb","year":"1999","journal-title":"Keio J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI105200","article-title":"Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets","volume":"44","author":"CS Lieber","year":"1965","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00005792-196209000-00003","article-title":"Fatty liver: a study of 270 patients with biopsy proven fatty liver and review of the literature","volume":"41","author":"CM Leevy","year":"1962","journal-title":"Medicine (Baltimore)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(84)90295-2","article-title":"Prospective evaluation of alcohol abuse and alcoholic liver injury in men as predictors of development of cirrhosis","volume":"2","author":"TI Sorensen","year":"1984","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.fct.2011.11.030","article-title":"Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1","volume":"50","author":"T Zeng","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1258\/ebm.2009.009249","article-title":"Pathogenesis of alcoholic liver disease: the role of nuclear receptors","volume":"235","author":"MA Gyamfi","year":"2010","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","article-title":"Molecular mechanisms of alcoholic fatty liver","volume":"33","author":"V Purohit","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.3748\/wjg.v13.i37.4974","article-title":"Alcohol-induced steatosis in liver cells","volume":"13","author":"TM Donohue Jr","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1159\/000324289","article-title":"Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity","volume":"28","author":"AI Cederbaum","year":"2010","journal-title":"Dig Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jhep.2012.08.018","article-title":"CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease","volume":"58","author":"TM Leung","year":"2013","journal-title":"J Hepatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9223","DOI":"10.1073\/pnas.84.24.9223","article-title":"Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: correlation with radical formation in vitro","volume":"84","author":"LA Reinke","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/hep.22222","article-title":"Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice","volume":"47","author":"Y Lu","year":"2008","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1386-6346(00)00089-9","article-title":"Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice","volume":"19","author":"YY Wan","year":"2001","journal-title":"Hepatol Res"},{"key":"ref17","first-page":"G1259","article-title":"CYP2E1 is not involved in early alcohol-induced liver injury","volume":"277","author":"H Kono","year":"1999","journal-title":"Am J Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.alcohol.2004.07.004","article-title":"Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins","volume":"34","author":"M You","year":"2004","journal-title":"Alcohol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1530-0277.2010.01338.x","article-title":"Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice","volume":"35","author":"Z Zhao","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/hep.20399","article-title":"Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage","volume":"40","author":"T Nakajima","year":"2004","journal-title":"Hepatology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.alcohol.2004.07.005","article-title":"Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha","volume":"34","author":"DW Crabb","year":"2004","journal-title":"Alcohol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00204-009-0457-4","article-title":"Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis","volume":"83","author":"T Zeng","year":"2009","journal-title":"Arch Toxicol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1258\/ebm.2011.010360","article-title":"The emerging role of autophagy in alcoholic liver disease","volume":"236","author":"WX Ding","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"M You","year":"2002","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.90358.2008","article-title":"Resveratrol alleviates alcoholic fatty liver in mice","volume":"295","author":"JM Ajmo","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.taap.2007.06.018","article-title":"Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice","volume":"223","author":"HQ Yin","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jhep.2006.05.009","article-title":"Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model","volume":"45","author":"C Ji","year":"2006","journal-title":"J Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"WX Ding","year":"2010","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10735-013-9483-x","article-title":"Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol-treated rats: an immunohistochemical and electron microscopic study","volume":"44","author":"N Eid","year":"2013","journal-title":"J Mol Histol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.1840100417","article-title":"Experimental methods of ethanol administration","volume":"10","author":"CS Lieber","year":"1989","journal-title":"Hepatology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.bbagen.2013.06.028","article-title":"The activation of HO-1\/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress","volume":"1830","author":"T Zeng","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/0960327109353057","article-title":"The modulatory effects of garlic oil on hepatic cytochrome P450s in mice","volume":"28","author":"T Zeng","year":"2009","journal-title":"Hum Exp Toxicol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0891-5849(97)00017-8","article-title":"Cytochrome P-450 2E1 in rat liver peroxisomes: downregulation by ischemia\/reperfusion-induced oxidative stress","volume":"23","author":"K Pahan","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tox.2012.03.005","article-title":"PI3K\/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice","volume":"296","author":"T Zeng","year":"2012","journal-title":"Toxicology"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Shen Z, Liang X, Rogers CQ, Rideout D, You M (2009) Involvement of Adiponectin-SIRT1-AMPK Signaling in the Protective Action of Rosiglitazone against Alcoholic Fatty Liver in Mice. Am J Physiol Gastrointest Liver Physiol.","DOI":"10.1152\/ajpgi.00456.2009"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2165\/00128071-200809010-00002","article-title":"Peroxisome proliferator-activated receptors (PPARs) and the human skin: importance of PPARs in skin physiology and dermatologic diseases","volume":"9","author":"P Sertznig","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.2165\/00003495-200565170-00003","article-title":"Pathophysiological basis for antioxidant therapy in chronic liver disease","volume":"65","author":"J Medina","year":"2005","journal-title":"Drugs"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mam.2007.09.004","article-title":"Oxidative mechanisms in the pathogenesis of alcoholic liver disease","volume":"29","author":"E Albano","year":"2008","journal-title":"Mol Aspects Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0002-9440(10)63473-6","article-title":"A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production","volume":"163","author":"Z Zhou","year":"2003","journal-title":"Am J Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-5793(97)00805-3","article-title":"TNF-alpha downregulates the peroxisome proliferator activated receptor-alpha and the mRNAs encoding peroxisomal proteins in rat liver","volume":"412","author":"K Beier","year":"1997","journal-title":"FEBS Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00056.2004","article-title":"Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver","volume":"287","author":"M You","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbalip.2007.04.018","article-title":"Modulation of PPAR activity via phosphorylation","volume":"1771","author":"KA Burns","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11523-011-0176-7","article-title":"Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs","volume":"6","author":"S Ogita","year":"2011","journal-title":"Target Oncol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/cs0870441","article-title":"Fatty acid synthesis by rat liver after chronic ethanol feeding with a low-fat diet","volume":"87","author":"KJ Simpson","year":"1994","journal-title":"Clin Sci (Lond)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cbi.2007.05.008","article-title":"Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity","volume":"169","author":"SH Ki","year":"2007","journal-title":"Chem Biol Interact"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1210\/me.2007-0036","article-title":"Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health","volume":"21","author":"L He","year":"2007","journal-title":"Mol Endocrinol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.biocel.2004.02.005","article-title":"Methods for monitoring autophagy","volume":"36","author":"N Mizushima","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"G Bjorkoy","year":"2009","journal-title":"Methods Enzymol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1476-511X-10-246","article-title":"Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice","volume":"10","author":"L Kong","year":"2011","journal-title":"Lipids Health Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/hep.23090","article-title":"Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha","volume":"50","author":"X Kang","year":"2009","journal-title":"Hepatology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1751-2980.2011.00569.x","article-title":"Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence","volume":"13","author":"H Zhu","year":"2012","journal-title":"J Dig Dis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/JOE-09-0359","article-title":"PPAR control: it&apos;s SIRTainly as easy as PGC","volume":"204","author":"MC Sugden","year":"2010","journal-title":"Journal of Endocrinology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1089\/jmf.2009.0085","article-title":"Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat","volume":"12","author":"K Cho","year":"2009","journal-title":"J Med Food"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.jnutbio.2012.12.002","article-title":"Increased dietary fat contributes to dysregulation of the LKB1\/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis","volume":"24","author":"CT Shearn","year":"2013","journal-title":"J Nutr Biochem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nrc1753","article-title":"Oncogenic PI3K deregulates transcription and translation","volume":"5","author":"AG Bader","year":"2005","journal-title":"Nat Rev Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:14:01Z","timestamp":1588965241000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098658"}},"subtitle":[],"editor":[{"given":"Irina U.","family":"Agoulnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,3]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098658","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,3]]}}}