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Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. Brazilian Journal of Infectious Diseases."},{"key":"ref12","first-page":"1018","article-title":"III Brazilian Thoracic Association Guidelines on tuberculosis","volume":"35(10)","author":"MB Conde","year":"2009","journal-title":"J Bras Pneumol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1017\/S0031182012000765","article-title":"Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology","volume":"139(11)","author":"JP Dubey","year":"2012","journal-title":"Parasitology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S1473-3099(13)70187-7","article-title":"Effect of improved tuberculosis screening and isoniazid preventive therapy on incidence of tuberculosis and death in patients with HIV in clinics in Rio de Janeiro, Brazil: a stepped wedge, cluster-randomised trial","volume":"13(10)","author":"B Durovni","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/QAD.0b013e328327964f","article-title":"Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort","volume":"23(5)","author":"JE Golub","year":"2009","journal-title":"Aids"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Grinsztejn B, Hosseinipour M, Ribaudo H, Havlir D, Cohen M, <etal>et al<\/etal>.. (2014). Effects of Early versus Delayed Initiation of Antiretroviral Therapy on HIV Clinical Outcomes: Results from the HPTN 052. Lancet Infect Dis Accepted.","DOI":"10.1016\/S1473-3099(13)70692-3"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e59768","DOI":"10.1371\/journal.pone.0059768","article-title":"Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART era","volume":"8(4)","author":"B Grinsztejn","year":"2013","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1097\/QAD.0b013e32832ec494","article-title":"Early mortality and cause of deaths in patients using HAART in Brazil and the United States","volume":"23(16)","author":"B Grinsztejn","year":"2009","journal-title":"Aids"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/QAI.0b013e3180decb6a","article-title":"Comparison of clinical response to initial highly active antiretroviral therapy in the patients in clinical care in the United States and Brazil","volume":"45(5)","author":"B Grinsztejn","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref20","first-page":"414","article-title":"Prevalence of Toxoplasma infection in a cohort of homosexual men at risk of AIDS and toxoplasmic encephalitis","volume":"6(4)","author":"DM Israelski","year":"1993","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1086\/313843","article-title":"Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy","volume":"30","author":"JE Kaplan","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1097\/QAD.0b013e32830007cd","article-title":"Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa","volume":"22(15)","author":"SD Lawn","year":"2008","journal-title":"Aids"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1001\/jama.282.23.2220","article-title":"AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: the Swiss HIV Cohort Study","volume":"282(23)","author":"B Ledergerber","year":"1999","journal-title":"Jama"},{"key":"ref24","first-page":"807","article-title":"Use of a clinical laboratory database to estimate Toxoplasma seroprevalence among human immunodeficiency virus-infected patients. 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J Acquir Immune Defic Syndr 51(5): 624\u2013630 610.1097\/QAI.1090b1013e3181a1094ecf1095."},{"key":"ref31","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338(13)","author":"FJ Palella Jr","year":"1998","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0140-6736(93)91817-6","article-title":"Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection","volume":"342(8866)","author":"JW Pape","year":"1993","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s15010-006-5030-y","article-title":"Opportunistic infections and other AIDS-defining illnesses in Poland in 2000\u20132002","volume":"34(4)","author":"RB Podlasin","year":"2006","journal-title":"Infection"},{"key":"ref34","unstructured":"Ribeiro S, Luz PM, Campos D, Moreira R, Japiassu A, <etal>et al<\/etal>.. (2013). Incidence and determinants of severe morbidity among HIV-infected patients from Rio de Janeiro, Brazil, 2000\u20132010. Antiviral Therapy."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.inhe.2010.12.004","article-title":"Impact of the National Access to Antiretroviral Program on the incidence of opportunistic infections in Thailand","volume":"3(2)","author":"A Rojanawiwat","year":"2011","journal-title":"International Health"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"397","DOI":"10.7326\/0003-4819-145-6-200609190-00003","article-title":"Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City","volume":"145(6)","author":"JE Sackoff","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1212\/WNL.56.2.257","article-title":"HIV-associated neurologic disease incidence changes:: Multicenter AIDS Cohort Study, 1990\u20131998","volume":"56(2)","author":"N Sacktor","year":"2001","journal-title":"Neurology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1086\/374358","article-title":"Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989\u20131997","volume":"36(9)","author":"FJ San-Andres","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1086\/338641","article-title":"Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy","volume":"34(4)","author":"G Santoro-Lopes","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/QAD.0b013e32835b0fa2","article-title":"Declining incidence of AIDS-defining opportunistic illnesses: results from 16 years of population-based AIDS surveillance","volume":"27(4)","author":"L Schwarcz","year":"2013","journal-title":"Aids"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1056\/NEJMoa0910370","article-title":"Early versus standard antiretroviral therapy for HIV-infected adults in Haiti","volume":"363(3)","author":"P Severe","year":"2010","journal-title":"N Engl J Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1001270","DOI":"10.1371\/journal.pmed.1001270","article-title":"Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis","volume":"9(7)","author":"AB Suthar","year":"2012","journal-title":"PLoS Med"},{"key":"ref43","unstructured":"16.WHO (2007). WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children."},{"key":"ref44","unstructured":"29.WHO (2011). Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings."},{"key":"ref45","unstructured":"11.WHO (2012). Global tuberculosis Report."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S0036-46652013000100005","article-title":"Evaluation of seroepidemiological toxoplasmosis in HIV\/AIDS patients in the south of Brazil","volume":"55(1)","author":"GA Xavier","year":"2013","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/ije\/30.4.864","article-title":"Incidence of primary opportunistic infections in two human immunodeficiency virus-infected French clinical cohorts","volume":"30(4)","author":"Y Yazdanpanah","year":"2001","journal-title":"Int J Epidemiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T09:00:39Z","timestamp":1565514039000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098666"}},"subtitle":[],"editor":[{"given":"Mark","family":"Wainberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,5]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098666","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,5]]}}}