{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:40:45Z","timestamp":1770136845036,"version":"3.49.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098719","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T20:34:43Z","timestamp":1401395683000},"page":"e98719","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Altered Immunohistochemical Expression of Mast Cell Tryptase and Chymase in the Pathogenesis of Oral Submucous Fibrosis and Malignant Transformation of the Overlying Epithelium"],"prefix":"10.1371","volume":"9","author":[{"given":"Archana","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv S.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bansari A.","family":"Bhuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatinder S.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash P.","family":"Nehete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0970-9290.33785","article-title":"Oral Submucous fibrosis; A clinicopathological study in Chennai","volume":"18","author":"KK Kumar","year":"2007","journal-title":"Ind J Dent Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0714.2005.00325.x","article-title":"Molecular pathogenesis of oral submucous fibrosis \u2013 a Collagen metabolic disorder","volume":"34","author":"P Rajalalitha","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0714.2010.00995.x","article-title":"Evaluation of myofibroblasts in oral submucous fibrosis: correlation with disease severity","volume":"40","author":"PV Angadi","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10006-010-0219-8","article-title":"Role Areca nut in pathogenesis of oral submucous fibrosis: revisited","volume":"15","author":"V Punnya","year":"2011","journal-title":"Oral and Maxillofac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1172\/JCI119290","article-title":"Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts","volume":"99","author":"JA Cairns","year":"1997","journal-title":"J Clin Invset"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02918088","article-title":"Mast cells, fibroblasts and fibrosis. New clues to the riddle of mast cells","volume":"6","author":"KL Choi","year":"1987","journal-title":"Immunol Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"L193","DOI":"10.1152\/ajplung.2000.278.1.L193","article-title":"Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2","volume":"278","author":"IA Akers","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.232422999","article-title":"Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPAR: Possible relevance to human fibrotic disorders","volume":"99","author":"MB Frungeiri","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref9","first-page":"1175","article-title":"Intrahepatic mast cells in chronic liver diseases","volume":"22","author":"DJ Farrell","year":"1995","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1365-2133.1998.02114.x","article-title":"Dermal mast cells in scleroderma: their skin density, tryptase\/chymase phenotypes and degranulation","volume":"138","author":"S Akimoto","year":"1998","journal-title":"Br J Dermatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.0906-6705.2005.00315.x","article-title":"Mast cell accumulation and cytokine expression in the tight skin mouse model of scleroderma","volume":"14","author":"HW Wang","year":"2005","journal-title":"Exp Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/jcp.53.11.858","article-title":"Mast cells: the forgotten cells of renal fibrosis","volume":"53","author":"IS Roberts","year":"2000","journal-title":"J Clin Pathol"},{"key":"ref13","first-page":"187","article-title":"Mast cell density in oral submucous fibrosis","volume":"49","author":"AP Bhatt","year":"1997","journal-title":"J Ind Dent Assoc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0973-029X.33959","article-title":"Mast cells are increased in leukoplakia, oral submucous fibrosis, oral lichen planus and oral squamous cell carcinoma","volume":"11","author":"MR Ankle","year":"2007","journal-title":"J Oral and Maxillofac Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0714.2008.00649.x","article-title":"The role of basic fibroblast growth factor in oral submucous fibrosis pathogenesis","volume":"37","author":"KA Bishen","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0970-9290.80009","article-title":"Immunohistochemical evaluation of mast cells and vascular endothelial proliferation in oral submucous fibrosis","volume":"22","author":"B Sabarinath","year":"2011","journal-title":"Ind J Dent Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.12816\/0006017","article-title":"Mast cell density in oral submucous fibrosis: a possible role in pathogenesis","volume":"7","author":"R Pujari","year":"2013","journal-title":"Int J Health Sci, Qassim University"},{"key":"ref18","first-page":"144","article-title":"Quantitative analysis of mast cells in oral submucous fibrosis","volume":"6","author":"S Chavan","year":"2013","journal-title":"Al Ameen J Med Sci"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Khatri MJ, Desai RS, Mamatha GS, Kulkarni M, Khatri J (2013) Immunohistochemical expression of mast cells using c- kit in various grades of oral submucous fibrosis. ISRN Pathology Article ID 543976. 5 Pages.","DOI":"10.1155\/2013\/543976"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.4317\/medoral.18226","article-title":"Expression of transforming growth factor \u03b2 and its correlation with lipodystrophy in oral submucous fibrosis: an Immunohistochemical study","volume":"18","author":"AD Kale","year":"2013","journal-title":"Med Oral Pathol Oral Cir Bucal"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"DD Metcalfe","year":"1997","journal-title":"Physiol Rev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-0714.1997.tb00025.x","article-title":"An immunohistochemical study of oral submucous fibrosis","volume":"26","author":"MF Haque","year":"1997","journal-title":"J Oral Pathol Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1006\/cyto.1997.0342","article-title":"Immunohistochemical localization of cytokines and growth factors in oral submucous fibrosis","volume":"10","author":"MF Haque","year":"1998","journal-title":"Cytokine"},{"key":"ref24","first-page":"513","article-title":"Interleukin-1 beta in oral submucous fibrosis, verrucous hyperplasia and squamous cell carcinoma tissues","volume":"15","author":"CC Tsai","year":"1999","journal-title":"Kaohsiung J Med Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/08977194.2011.582839","article-title":"Role of TGF-\u03b2 and BMP 7 in pathogenesis of oral submucous fibrosis","volume":"29","author":"I Khan","year":"2011","journal-title":"Growth Factor"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2559.2006.02534.x","article-title":"Mast cells in diffuse large B-cell lymphoma: their role in fibrosis","volume":"49","author":"H Fukushima","year":"2006","journal-title":"Histopathol"},{"key":"ref27","first-page":"203","article-title":"Tumour angiogenesis","volume":"43","author":"J Folkman","year":"1985","journal-title":"Adv Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","article-title":"Angiogenesis","volume":"267","author":"J Folkman","year":"1992","journal-title":"J Biol Chem"},{"key":"ref29","first-page":"2013","article-title":"Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer","volume":"56","author":"H Yoshiji","year":"1996","journal-title":"Cancer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis\u2014correlation in invasive breast carcinoma","volume":"324","author":"N Weidner","year":"1991","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1200\/JCO.1997.15.2.826","article-title":"Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma","volume":"15","author":"N Tanigawa","year":"1997","journal-title":"J Clin Oncol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00432-005-0003-6","article-title":"Prognostic significance of VEGF immunohistochemical expression and tumor angiogenesis in head and neck squamous cell carcinoma","volume":"131","author":"PA Kyzas","year":"2005","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-0714.2003.00128.x","article-title":"Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma","volume":"32","author":"A Iamaroon","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/jcp.54.12.940","article-title":"The prognostic relevance of angiogenesis and mast cells in squamous cell carcinoma of the oesophagus","volume":"54","author":"GO Elpek","year":"2001","journal-title":"J Clin Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1073\/pnas.83.12.4464","article-title":"Two types of human mast cells have distinct neutral protease compositions","volume":"83","author":"AA Irani","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1600-0714.2004.00297.x","article-title":"Characterization of mast Cell subpopulation in lip Cancer","volume":"34","author":"IG Rojas","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1600-065X.2007.00509.x","article-title":"Mast cell tryptase and chymase in inflammation and host defense","volume":"217","author":"GH Caughey","year":"2007","journal-title":"Immunol Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/154411130301400304","article-title":"Mast cells and oral inflammation","volume":"14","author":"LJ Walsh","year":"2003","journal-title":"Crit Rev in Oral Biol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-0714.1995.tb01180.x","article-title":"Relationship between mast cell degranulation and inflammation in the oral cavity","volume":"24","author":"LJ Walsh","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0714.1993.tb00116.x","article-title":"Peripheral nerves and mast cells in normal buccal mucosa","volume":"22","author":"H Roukonen","year":"1993","journal-title":"J Oral Pathol Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-0625.1994.tb00291.x","article-title":"Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme-histochemical staining techniques","volume":"3","author":"B Algermissen","year":"1994","journal-title":"Exp Dermatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.4049\/jimmunol.158.5.2310","article-title":"Human mast cells activate fibroblasts: Tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis","volume":"158","author":"BL Gruber","year":"1997","journal-title":"J Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI115330","article-title":"Mast cell tryptase is a mitogen for cultured fibroblasts","volume":"88","author":"SJ Ruoss","year":"1991","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1073\/pnas.94.17.9017","article-title":"Chymase cleavage of stem cell factor yields a bioactive, soluble product","volume":"94","author":"BJ Longley","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1074\/jbc.272.11.7127","article-title":"Cleavage of type II precollagen by human mast cell chymase initiates collagen fibril formation and generates a unique carboxyl-terminal propeptide","volume":"272","author":"MW Kofford","year":"1997","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1096\/fj.00-0273com","article-title":"Activation of paracrine TGF-\u03b21 signalling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase","volume":"15","author":"KA Lingstedt","year":"2001","journal-title":"FASEB J"},{"key":"ref47","first-page":"604","article-title":"In vitro production of interleukin-6 by human gingival, normal buccal mucosa, and oral submucous fibrosis fibroblasts treated with betel-nut alkaloids","volume":"11","author":"CC Chen","year":"1995","journal-title":"Kaohsiung J Med Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.276.5309.75","article-title":"Wound healing-aiming for perfect skin regeneration","volume":"276","author":"P Martin","year":"1997","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrc1877","article-title":"Fibroblasts in cancer","volume":"6","author":"R Kalluri","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"TA Wynn","year":"2008","journal-title":"J Pathol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0714.2010.00999.x","article-title":"Significance of myofibroblasts in oral squamous cell carcinoma","volume":"40","author":"C Thode","year":"2011","journal-title":"J Oral Pathol Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1242\/jcs.01005","article-title":"Fibroblast heterogeneity: more than skin deep","volume":"117(","author":"JM Sorrell","year":"2004","journal-title":"J Cell Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1242\/jcs.107.8.2285","article-title":"Dermal fibroblasts activate keratinocyte outgrowth on collagen gels","volume":"107","author":"TL Taun","year":"1994","journal-title":"J Cell Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.4049\/jimmunol.160.10.5053","article-title":"Human Mast cells augment fibroblast proliferation by heterotypic cell-cell adhesion and action of IL-4","volume":"160","author":"A Trautmann","year":"1998","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.1073\/pnas.211053698","article-title":"Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging","volume":"98","author":"A Krtolica","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature03096","article-title":"Stromal fibroblasts in cancer initiation and progression","volume":"432","author":"NA Bhowmick","year":"2004","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1101\/gad.13.11.1382","article-title":"Inflammatory mast cells upregulate angiogenesis during squamous epithelial carcinogenesis","volume":"13","author":"LM Coussens","year":"1999","journal-title":"Genes Dev"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.0022-202x.2001.01705.x","article-title":"Mast cell-fibroblast interactions: human mast cells as source and inducers of fibroblast and epithelial growth factors","volume":"118","author":"M Artuc","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrc1477","article-title":"Friends or foes\u2013bipolar effects of the tumour stroma in cancer","volume":"4","author":"MM Mueller","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0714.2011.01057.x","article-title":"Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression","volume":"41","author":"IG Rojas","year":"2012","journal-title":"J Oral Pathol Med"},{"key":"ref61","unstructured":"Folkman J (2000) Tumor Angiogenesis.In: Cancer Medicine, 5th ed, London: Decker pp 13\u201352."},{"key":"ref62","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/2211552811201040347","article-title":"Immunohistochemical expression of vascular endothelial growth factor (VEGF) and its possible role in tumor progression during malignant transformation of atrophic epithelium in oral submucous fibrosis","volume":"1","author":"RS Desai","year":"2012","journal-title":"Current Angiogenesis"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.oraloncology.2010.04.004","article-title":"Immunohistochemical expression of CD34 for characterization and quantification of mucosal vasculature and its probable role in malignant transformation of atrophic epithelium in oral submucous fibrosis","volume":"46","author":"RS Desai","year":"2010","journal-title":"Oral Oncol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1177\/002215540104900816","article-title":"The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesion of uterine cervix","volume":"49","author":"L Benitez-Bribiesca","year":"2001","journal-title":"J Histochem and Cytochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T19:54:38Z","timestamp":1689278078000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098719"}},"subtitle":[],"editor":[{"given":"Muy-Teck","family":"Teh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":64,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098719","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,29]]}}}