{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:23:08Z","timestamp":1790623388392,"version":"4.1.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T00:00:00Z","timestamp":1401667200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098741","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T18:27:59Z","timestamp":1401733679000},"page":"e98741","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":327,"title":["Changes in Abundance of Oral Microbiota Associated with Oral Cancer"],"prefix":"10.1371","volume":"9","author":[{"given":"Brian L.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Kuczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Huey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M.","family":"Corby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L. S.","family":"Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Nightingale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Ross","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"DeLacure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Veeramachaneni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Olshen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna G.","family":"Albertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Muy-Teck Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Parkin DM, Pisani P, Ferlay J (1999) Global cancer statistics. CA Cancer J Clin 49: 33\u201364, 31.","DOI":"10.3322\/canjclin.49.1.33"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/cncr.20998","article-title":"Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20\u201344 years","volume":"103","author":"CH Shiboski","year":"2005","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.joms.2004.03.010","article-title":"Tobacco smoking history and presentation of oral squamous cell carcinoma","volume":"62","author":"BL Schmidt","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1053\/j.seminoncol.2004.09.011","article-title":"Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity","volume":"31","author":"ML Gillison","year":"2004","journal-title":"Semin Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0140-6736(75)90498-5","article-title":"A model for gastric cancer epidemiology","volume":"2","author":"P Correa","year":"1975","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0966-842X(02)02360-0","article-title":"How bacteria could cause cancer: one step at a time","volume":"10","author":"AJ Lax","year":"2002","journal-title":"Trends in microbiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1479-5876-4-14","article-title":"Bacteria and cancer: cause, coincidence or cure? A review","volume":"4","author":"DL Mager","year":"2006","journal-title":"Journal of translational medicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hed.21140","article-title":"Exploring the link between microorganisms and oral cancer: a systematic review of the literature","volume":"31","author":"SJ Hooper","year":"2009","journal-title":"Head & neck"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"FE Dewhirst","year":"2010","journal-title":"Journal of bacteriology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tim.2005.09.006","article-title":"Oral microbial communities in sickness and in health","volume":"13","author":"HF Jenkinson","year":"2005","journal-title":"Trends Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1158\/1055-9965.EPI-09-0334","article-title":"Chronic periodontitis and the incidence of head and neck squamous cell carcinoma","volume":"18","author":"M Tezal","year":"2009","journal-title":"Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hed.21140","article-title":"Exploring the link between microorganisms and oral cancer: a systematic review of the literature","volume":"31","author":"SJ Hooper","year":"2009","journal-title":"Head Neck"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1368-8375(98)80012-2","article-title":"The microflora associated with human oral carcinomas","volume":"34","author":"KN Nagy","year":"1998","journal-title":"Oral oncology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1128\/JCM.44.5.1719-1725.2006","article-title":"Viable bacteria present within oral squamous cell carcinoma tissue","volume":"44","author":"SJ Hooper","year":"2006","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1099\/jmm.0.46918-0","article-title":"A molecular analysis of the bacteria present within oral squamous cell carcinoma","volume":"56","author":"SJ Hooper","year":"2007","journal-title":"Journal of medical microbiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2180-12-144","article-title":"Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma","volume":"12","author":"S Pushalkar","year":"2012","journal-title":"BMC microbiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/hmg\/ddr593","article-title":"Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous cell carcinoma","volume":"21","author":"G Bebek","year":"2012","journal-title":"Human molecular genetics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg3129","article-title":"Experimental and analytical tools for studying the human microbiome","volume":"13","author":"J Kuczynski","year":"2012","journal-title":"Nature reviews Genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1128\/JCM.43.11.5721-5732.2005","article-title":"Defining the normal bacterial flora of the oral cavity","volume":"43","author":"JA Aas","year":"2005","journal-title":"Journal of clinical microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/154405910808701104","article-title":"Pyrosequencing analysis of the oral microflora of healthy adults","volume":"87","author":"BJ Keijser","year":"2008","journal-title":"Journal of dental research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy &quot;core microbiome&quot; of oral microbial communities","volume":"9","author":"E Zaura","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1101\/gr.084616.108","article-title":"Global diversity in the human salivary microbiome","volume":"19","author":"I Nasidze","year":"2009","journal-title":"Genome research"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ab.2009.04.034","article-title":"Comparative analysis of human saliva microbiome diversity by barcoded pyrosequencing and cloning approaches","volume":"391","author":"I Nasidze","year":"2009","journal-title":"Analytical biochemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ismej.2010.30","article-title":"Bacterial diversity in the oral cavity of 10 healthy individuals","volume":"4","author":"EM Bik","year":"2010","journal-title":"The ISME journal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/1471-2164-11-523","article-title":"Study of inter- and intra-individual variations in the salivary microbiota","volume":"11","author":"V Lazarevic","year":"2010","journal-title":"BMC genomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1099\/mic.0.043174-0","article-title":"The bacterial microbiota in the oral mucosa of rural Amerindians","volume":"156","author":"M Contreras","year":"2010","journal-title":"Microbiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1574-695X.2010.00773.x","article-title":"Microbial diversity in saliva of oral squamous cell carcinoma","volume":"61","author":"S Pushalkar","year":"2011","journal-title":"FEMS immunology and medical microbiology"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Stahringer SS, Clemente JC, Corley RP, Hewitt J, Knights D, et al. (2012) Nurture trumps nature in a longitudinal survey of salivary bacterial communities in twins from early adolescence to early adulthood. Genome research.","DOI":"10.1101\/gr.140608.112"},{"key":"ref29","first-page":"1727","article-title":"A genetic explanation of Slaughter&apos;s concept of field cancerization: evidence and clinical implications","volume":"63","author":"BJ Braakhuis","year":"2003","journal-title":"Cancer research"},{"key":"ref30","first-page":"1523","article-title":"Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications","volume":"7","author":"MP Tabor","year":"2001","journal-title":"Clin Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nmeth.1361","article-title":"Accurate determination of microbial diversity from 454 pyrosequencing data","volume":"6","author":"C Quince","year":"2009","journal-title":"Nature methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"JG Caporaso","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1479-5876-3-27","article-title":"The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects","volume":"3","author":"DL Mager","year":"2005","journal-title":"Journal of translational medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-695X.2011.00789.x","article-title":"Prevotella intermedia stimulates tissue-type plasminogen activator and plasminogen activator inhibitor-2 expression via multiple signaling pathways in human periodontal ligament cells","volume":"62","author":"SM Guan","year":"2011","journal-title":"FEMS immunology and medical microbiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.coms.2008.02.002","article-title":"Management of the N0 neck in oral squamous cell carcinoma","volume":"20","author":"A Cheng","year":"2008","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/bioinformatics\/bts342","article-title":"Associating microbiome composition with environmental covariates using generalized UniFrac distances","volume":"28","author":"J Chen","year":"2012","journal-title":"Bioinformatics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/jcpe.12087","article-title":"Subgingival microbiome in smokers and non-smokers in periodontitis: an exploratory study using traditional targeted techniques and a next-generation sequencing","volume":"40","author":"S Bizzarro","year":"2013","journal-title":"Journal of clinical periodontology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1128\/IAI.05371-11","article-title":"Tobacco smoking affects bacterial acquisition and colonization in oral biofilms","volume":"79","author":"PS Kumar","year":"2011","journal-title":"Infection and immunity"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/CMR.00012-10","article-title":"Role of bacteria in oncogenesis","volume":"23","author":"AH Chang","year":"2010","journal-title":"Clinical microbiology reviews"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/0022034511399096","article-title":"Stick to your gums: mechanisms of oral microbial adherence","volume":"90","author":"AH Nobbs","year":"2011","journal-title":"Journal of dental research"},{"key":"ref41","first-page":"558","article-title":"Streptococcus cristatus modulates the Fusobacterium nucleatum-induced epithelial interleukin-8 response through the nuclear factor-kappa B pathway","volume":"46","author":"G Zhang","year":"2011","journal-title":"Journal of periodontal research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.2041-1014.2010.00600.x","article-title":"Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-kappaB","volume":"26","author":"G Zhang","year":"2011","journal-title":"Molecular oral microbiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1902\/jop.2010.090664","article-title":"Biofilm formation enhances the oxygen tolerance and invasiveness of Fusobacterium nucleatum in an oral mucosa culture model","volume":"81","author":"UK Gursoy","year":"2010","journal-title":"Journal of periodontology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gr.126516.111","article-title":"Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"22","author":"M Castellarin","year":"2012","journal-title":"Genome research"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"AD Kostic","year":"2012","journal-title":"Genome research"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"172","DOI":"10.2174\/1874210601004010172","article-title":"Salivary markers for oral cancer detection","volume":"4","author":"AK Markopoulos","year":"2010","journal-title":"The open dentistry journal"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Matthews AM, Kaur H, Dodd M, D&apos;Souza J, Liloglou T, et al. (2012) Saliva collection methods for DNA biomarker analysis in oral cancer patients. The British journal of oral &amp; maxillofacial surgery.","DOI":"10.1016\/j.bjoms.2012.09.017"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/ijc.25881","article-title":"Salivary metabolite signatures of oral cancer and leukoplakia","volume":"129","author":"J Wei","year":"2011","journal-title":"International journal of cancer Journal international du cancer"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1479-5876-3-27","article-title":"The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects","volume":"3","author":"DL Mager","year":"2005","journal-title":"J Transl Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e15216","DOI":"10.1371\/journal.pone.0015216","article-title":"Disordered microbial communities in the upper respiratory tract of cigarette smokers","volume":"5","author":"ES Charlson","year":"2010","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Applied and environmental microbiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1093\/nar\/gkn491","article-title":"Accurate taxonomy assignments from 16S rRNA sequences produced by highly parallel pyrosequencers","volume":"36","author":"Z Liu","year":"2008","journal-title":"Nucleic acids research"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1093\/nar\/gkm541","article-title":"Short pyrosequencing reads suffice for accurate microbial community analysis","volume":"35","author":"Z Liu","year":"2007","journal-title":"Nucleic acids research"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/ismej.2010.171","article-title":"Examining the global distribution of dominant archaeal populations in soil","volume":"5","author":"ST Bates","year":"2011","journal-title":"The ISME journal"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nature methods"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"TZ DeSantis","year":"2006","journal-title":"Applied and environmental microbiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"C Lozupone","year":"2005","journal-title":"Applied and environmental microbiology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/AEM.01996-06","article-title":"Quantitative and qualitative beta diversity measures lead to different insights into factors that structure microbial communities","volume":"73","author":"CA Lozupone","year":"2007","journal-title":"Applied and environmental microbiology"},{"key":"ref59","unstructured":"Oksanen j, Blanchet FG, Kindt R, Legendre P, Minchin PR, et al. (2012) vegan: Community Ecology Package. R package version 2.0\u20135."}],"updated-by":[{"DOI":"10.1371\/journal.pone.0106297","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,8,15]],"date-time":"2014-08-15T00:00:00Z","timestamp":1408060800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T02:26:34Z","timestamp":1565490394000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":59,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098741","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,2]]}}}