{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:39:26Z","timestamp":1762101566291},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T00:00:00Z","timestamp":1402444800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098859","type":"journal-article","created":{"date-parts":[[2014,6,11]],"date-time":"2014-06-11T20:38:20Z","timestamp":1402519100000},"page":"e98859","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dasatinib Accelerates Valproic Acid-Induced Acute Myeloid Leukemia Cell Death by Regulation of Differentiation Capacity"],"prefix":"10.1371","volume":"9","author":[{"given":"Sook-Kyoung","family":"Heo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui-Kyu","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Joon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Cheol","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hawk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1158\/1078-0432.CCR-09-2416","article-title":"Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias","volume":"16","author":"BS Guerrouahen","year":"2010","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/leu.2009.267","article-title":"Dasatinib promotes ATRA-induced differentiation of AML cells","volume":"24","author":"PL Kropf","year":"2010","journal-title":"Leukemia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1158\/1078-0432.CCR-06-1112","article-title":"Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure","volume":"12","author":"FR Luo","year":"2006","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1182\/blood-2011-08-376087","article-title":"Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION)","volume":"119","author":"HM Kantarjian","year":"2012","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1056\/NEJMoa1002315","article-title":"Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia","volume":"362","author":"H Kantarjian","year":"2010","journal-title":"The New England journal of medicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood.V97.10.3234","article-title":"Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARalpha and PML-RARalpha","volume":"97","author":"M Gianni","year":"2001","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/leu.2008.28","article-title":"Gefitinib potentiates myeloid cell differentiation by ATRA","volume":"22","author":"MB Miranda","year":"2008","journal-title":"Leukemia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.leukres.2010.02.016","article-title":"Gefitinib enhances arsenic trioxide (AS<sub>2<\/sub>O<sub>3<\/sub>)-induced differentiation of acute promyelocytic leukemia cell line","volume":"34","author":"EK Noh","year":"2010","journal-title":"Leukemia research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/leu.2012.39","article-title":"Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL","volume":"26","author":"M Leiva","year":"2012","journal-title":"Leukemia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1182\/blood-2013-05-500629","article-title":"Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8; 21) AML cells","volume":"122","author":"ML Torgersen","year":"2013","journal-title":"Blood"},{"key":"ref11","first-page":"227","article-title":"Histone deacetylase inhibition by valproic acid down-regulates c-FLIP\/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy","volume":"15","author":"M Schuchmann","year":"2006","journal-title":"Oncology reports"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/01.cad.0000236302.89843.fc","article-title":"Valproic acid induces apoptosis in prostate carcinoma cell lines by activation of multiple death pathways","volume":"17","author":"A Angelucci","year":"2006","journal-title":"Anti-cancer drugs"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.surg.2005.09.019","article-title":"Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells","volume":"138","author":"WT Shen","year":"2005","journal-title":"Surgery"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0609.2009.01242.x","article-title":"Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro","volume":"83","author":"B Kircher","year":"2009","journal-title":"European journal of haematology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/sj.leu.2403390","article-title":"Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1","volume":"18","author":"R Tang","year":"2004","journal-title":"Leukemia"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000189798","article-title":"Rhein inhibits TNF-alpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis","volume":"46","author":"SK Heo","year":"2009","journal-title":"Journal of vascular research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.091744","article-title":"Cdks, cyclins and CKIs: roles beyond cell cycle regulation","volume":"140","author":"S Lim","year":"2013","journal-title":"Development"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mc.20872","article-title":"Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1\/cip1) expression in human colon carcinoma HT-29 cells","volume":"52","author":"D Zurlo","year":"2013","journal-title":"Molecular carcinogenesis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/carcin\/bgl043","article-title":"Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP","volume":"27","author":"SK Mantena","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1081\/DMR-120026497","article-title":"Chemical-induced apoptosis: formation of the Apaf-1 apoptosome","volume":"35","author":"K Cain","year":"2003","journal-title":"Drug metabolism reviews"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/leu.2011.390","article-title":"Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells","volume":"26","author":"J Congleton","year":"2012","journal-title":"Leukemia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e66915","DOI":"10.1371\/journal.pone.0066915","article-title":"MEK\/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia","volume":"8","author":"Y Fang","year":"2013","journal-title":"PloS one"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1182\/blood-2011-11-391722","article-title":"Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase\/gp91(phox) expression and the PARP-1\/PAR pathway of apoptosis","volume":"119","author":"J Aurelius","year":"2012","journal-title":"Blood"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1200\/JCO.2010.30.1820","article-title":"Therapeutic advances in acute myeloid leukemia","volume":"29","author":"A Burnett","year":"2011","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1182\/blood-2005-01-0178","article-title":"Drug therapy for acute myeloid leukemia","volume":"106","author":"MS Tallman","year":"2005","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/sj.leu.2402487","article-title":"Postremission therapy in older adults with acute myeloid leukemia: an opportunity for new drug development","volume":"16","author":"CA Schiffer","year":"2002","journal-title":"Leukemia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/35077251","article-title":"Haematopoietic cell transplantation as immunotherapy","volume":"411","author":"FR Appelbaum","year":"2001","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1182\/blood.V87.12.4979.bloodjournal87124979","article-title":"Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: a report from the Children&apos;s Cancer Group","volume":"87","author":"WG Woods","year":"1996","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1182\/blood-2010-12-326850","article-title":"Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation","volume":"117","author":"A Mazharian","year":"2011","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1038\/onc.2010.73","article-title":"Src family kinase\/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts","volume":"29","author":"YC Lee","year":"2010","journal-title":"Oncogene"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/leu.2010.84","article-title":"Second-generation TKI dasatinib inhibits proliferation of mesenchymal stem cells and osteoblast differentiation in vitro","volume":"24","author":"S Jonsson","year":"2010","journal-title":"Leukemia"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1471-2407-10-298","article-title":"The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts","volume":"10","author":"H Id Boufker","year":"2010","journal-title":"BMC cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e28555","DOI":"10.1371\/journal.pone.0028555","article-title":"The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells","volume":"6","author":"A Borriello","year":"2011","journal-title":"PloS one"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/leu.2010.151","article-title":"Robust in vivo differentiation of t(8;21)-positive acute myeloid leukemia blasts to neutrophilic granulocytes induced by treatment with dasatinib","volume":"24","author":"N Chevalier","year":"2010","journal-title":"Leukemia"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00277-011-1175-6","article-title":"Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cells","volume":"90","author":"AH Wang","year":"2011","journal-title":"Annals of hematology"},{"key":"ref36","first-page":"2231","article-title":"Combined valproic acid and celecoxib treatment induced synergistic cytotoxicity and apoptosis in neuroblastoma cells","volume":"31","author":"Y Chen","year":"2011","journal-title":"Anticancer research"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/1541-7786.MCR-10-0471","article-title":"Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis","volume":"9","author":"X Chen","year":"2011","journal-title":"Molecular cancer research: MCR"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1101\/gad.7.12a.2277","article-title":"Death-defying acts: a meeting review on apoptosis","volume":"7","author":"E White","year":"1993","journal-title":"Genes & development"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1091\/mbc.12.6.1569","article-title":"Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation","volume":"12","author":"RG Deschesnes","year":"2001","journal-title":"Molecular biology of the cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/471310a","article-title":"Programmed cell death: Apoptosis meets necrosis","volume":"471","author":"ME Peter","year":"2011","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"NA Thornberry","year":"1998","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1124\/mol.65.3.571","article-title":"Evidence of a functional role for p21WAF1\/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol","volume":"65","author":"RR Rosato","year":"2004","journal-title":"Molecular pharmacology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1158\/1078-0432.CCR-06-0980","article-title":"Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells","volume":"12","author":"W Fiskus","year":"2006","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/excr.1998.4191","article-title":"Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1\/CIP1\/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentation in human myelomonocytic leukemia cells","volume":"244","author":"Z Wang","year":"1998","journal-title":"Experimental cell research"},{"key":"ref45","first-page":"1259","article-title":"Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1\/CIP1\/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis","volume":"59","author":"Z Wang","year":"1999","journal-title":"Cancer research"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T22:27:51Z","timestamp":1597962471000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098859"}},"subtitle":[],"editor":[{"given":"Linda","family":"Bendall","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,11]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098859","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,11]]}}}