{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T18:13:07Z","timestamp":1774116787525,"version":"3.50.1"},"reference-count":95,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0098892","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T20:33:16Z","timestamp":1401913996000},"page":"e98892","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["MicroRNA Profiling as Tool for In Vitro Developmental Neurotoxicity Testing: The Case of Sodium Valproate"],"prefix":"10.1371","volume":"9","author":[{"given":"Lena","family":"Smirnova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sittka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Oelgeschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea E. M.","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Luch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals","volume":"368","author":"P Grandjean","year":"2006","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MOP.0b013e328336eb9a","article-title":"What causes autism? Exploring the environmental contribution","volume":"22","author":"PJ Landrigan","year":"2010","journal-title":"Curr Opin Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"DD Rice","year":"2000","journal-title":"Environ Health Perspect"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/jama.2010.860","article-title":"Increased Risk of ADHD Associated With Early Exposure to Pesticides, PCBs","volume":"304","author":"BM Kuehn","year":"2010","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/aje\/kwp427","article-title":"Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children","volume":"171","author":"SKS Sagiv","year":"2010","journal-title":"Am J Epidemiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1542\/peds.93.3.399","article-title":"Prevalence and health impact of developmental disabilities in US children","volume":"93","author":"CA Boyle","year":"1994","journal-title":"Pediatrics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1289\/ehp.01109s6813","article-title":"Toxic threats to neurologic development of children","volume":"109","author":"TT Schettler","year":"2001","journal-title":"Environ Health Perspect"},{"key":"ref8","first-page":"37","article-title":"The OECD guidelines for the testing of chemicals and pesticides","volume":"947","author":"J Buschmann","year":"2013","journal-title":"Methods MolBiol"},{"key":"ref9","unstructured":"Boyes WK, Dourson ML, Patterson J, Tilson HA, Sette WF, et al. (1997) EPA&apos;s neurotoxicity risk assessment guidelines. Vol. 40. pp. 175\u2013184."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.etap.2004.12.035","article-title":"In vitro and other alternative approaches to developmental neurotoxicity testing (DNT)","volume":"19","author":"P Lein","year":"2005","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuro.2012.06.006","article-title":"Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro","volume":"33","author":"A Visan","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref12","first-page":"428","article-title":"Control of developmental timing in Caenorhabditis elegans","volume":"10","author":"V Ambros","year":"2000","journal-title":"CurrOpinGenetDev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(01)00616-X","article-title":"microRNAs: tiny regulators with great potential","volume":"107","author":"V Ambros","year":"2001","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"RC Friedman","year":"2009","journal-title":"Genome Research"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"DP Bartel","year":"2004","journal-title":"Cell"},{"key":"ref16","first-page":"329","article-title":"Roles of small regulatory RNAs in determining neuronal identity","volume":"11","author":"X Li","year":"2010","journal-title":"Nature Publishing Group"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/npp.2012.87","article-title":"General principals of miRNA biogenesis and regulation in the brain","volume":"38","author":"D O'Carroll","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1126\/science.1109020","article-title":"MicroRNAs regulate brain morphogenesis in zebrafish","volume":"308","author":"AJ Giraldez","year":"2005","journal-title":"Science"},{"key":"ref19","first-page":"152","article-title":"Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice","volume":"2","author":"TT Huang","year":"2010","journal-title":"Fen Zi Xi Bao Sheng Wu Xue Bao"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2164-12-244","article-title":"Preferential regulation of miRNA targets by environmental chemicals in the human genome","volume":"12","author":"X Wu","year":"2011","journal-title":"BMC Genomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/870150","article-title":"MicroRNAs in Neurotoxicity","volume":"2012","author":"P Kaur","year":"2012","journal-title":"Journal of Toxicology"},{"key":"ref22","first-page":"499","article-title":"On the role of low-dose effects and epigenetics in toxicology","volume":"101","author":"L Smirnova","year":"2012","journal-title":"EXS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuro.2012.02.013","article-title":"Non-coding RNAs\u2014novel targets in neurotoxicity","volume":"33","author":"TL Tal","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/toxsci\/kfr293","article-title":"Transcriptomic Concentration-Response Evaluation of Valproic Acid, Cyproconazole, and Hexaconazole in the Neural Embryonic Stem Cell Test (ESTn)","volume":"125","author":"PT Theunissen","year":"2012","journal-title":"Toxicological Sciences"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/toxsci\/kfr134","article-title":"Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells","volume":"122","author":"PT Theunissen","year":"2011","journal-title":"Toxicol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10565-013-9250-5","article-title":"miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing","volume":"29","author":"G Pallocca","year":"2013","journal-title":"Cell Biol Toxicol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"A Ornoy","year":"2009","journal-title":"Reprod Toxicol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1399-5618.2009.00708.x","article-title":"Anticonvulsants in bipolar disorders: current research and practice and future directions","volume":"11","author":"CL Bowden","year":"2009","journal-title":"Bipolar Disord"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2009.03.013","article-title":"Histone deacetylase inhibitors as anti-neoplastic agents","volume":"280","author":"N Batty","year":"2009","journal-title":"Cancer Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tips.2007.02.005","article-title":"Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms","volume":"28","author":"PP Calabresi","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ejcb.2006.04.013","article-title":"The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum","volume":"85","author":"K Boeckeler","year":"2006","journal-title":"European Journal of Cell Biology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1523\/JNEUROSCI.5747-03.2004","article-title":"Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis","volume":"24","author":"Y Hao","year":"2004","journal-title":"JNeurosci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0197-0186(00)00013-9","article-title":"Mechanisms of action of valproate: a commentatory","volume":"37","author":"CU Johannessen","year":"2000","journal-title":"Neurochem Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"CJ Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0892-0362(00)00086-6","article-title":"Valproate enhances N-cadherin production in Xenopus embryos","volume":"22","author":"W Briner","year":"2000","journal-title":"Neurotoxicol Teratol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1038\/sj.onc.1210064","article-title":"The ups and downs of Wnt signaling in prevalent neurological disorders","volume":"25","author":"GV De Ferrari","year":"2006","journal-title":"Oncogene"},{"key":"ref37","first-page":"1269","article-title":"Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2","volume":"26","author":"D Huangfu","year":"2008","journal-title":"NatBiotechnol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1868-7083-4-5","article-title":"Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors","volume":"4","author":"GP Delcuve","year":"2012","journal-title":"Clin Epigenetics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.ede.0000249533.77900.74","article-title":"Developmental Arsenic Neurotoxicity in Retrospect","volume":"18","author":"P Grandjean","year":"2007","journal-title":"Epidemiology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0300-483X(99)00198-5","article-title":"Toxicologic evidence of developmental neurotoxicity of environmental chemicals","volume":"144","author":"HR Andersen","year":"2000","journal-title":"Toxicology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.2144\/00295st04","article-title":"Establishment and chimera analysis of 129\/SvEv- and C57BL\/6-derived mouse embryonic stem cell lines","volume":"29","author":"WW Auerbach","year":"2000","journal-title":"Biotechniques"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e37767","DOI":"10.1371\/journal.pone.0037767","article-title":"Expression of Toll-like receptors in the developing brain","volume":"7","author":"D Kaul","year":"2012","journal-title":"PLoS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"8514","DOI":"10.1073\/pnas.1432609100","article-title":"Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway","volume":"100","author":"S Lehnardt","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref44","first-page":"961","article-title":"The validated embryonic stem cell test to predict embryotoxicity in vitro","volume":"6","author":"AE Seiler","year":"2011","journal-title":"NatProtoc"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"157(1)","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TDT Schmittgen","year":"2008","journal-title":"Nature Protocols"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/j.1460-9568.2005.03978.x","article-title":"Regulation of miRNA expression during neural cell specification","volume":"21","author":"L Smirnova","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awr200","article-title":"Impaired neurosteroid synthesis in multiple sclerosis","volume":"134","author":"F Noorbakhsh","year":"2011","journal-title":"Brain"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1369\/jhc.2010.955757","article-title":"Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain","volume":"58","author":"KBK Larsen","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Grinberg I, Millen KJ (2005) The ZIC gene family in development and disease - Grinberg - 2005 - Clinical Genetics - Wiley Online Library. Clinical genetics.","DOI":"10.1111\/j.1399-0004.2005.00418.x"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1289\/ehp.7034","article-title":"Valproic acid teratogenicity: a toxicogenomics approach","volume":"112","author":"K Kultima","year":"2004","journal-title":"Environ Health Perspect"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/toxsci\/kfp002","article-title":"Valproic Acid-Induced Deregulation In Vitro of Genes Associated In Vivo with Neural Tube Defects","volume":"108","author":"M Jergil","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1096\/fj.06-6130com","article-title":"Post-transcriptional regulation of the let-7 microRNA during neural cell specification","volume":"21","author":"FG Wulczyn","year":"2007","journal-title":"FASEB J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"E207","DOI":"10.2527\/jas.2007-0473","article-title":"Defining the transcriptional signature of skeletal muscle stem cells","volume":"86","author":"Z Yablonka-Reuveni","year":"2007","journal-title":"Journal of Animal Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4161\/cc.10.3.14710","article-title":"MicroRNAs in skeletal myogenesis","volume":"10","author":"Y Ge","year":"2011","journal-title":"Cell Cycle"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1096\/fj.04-3425fje","article-title":"Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo","volume":"19","author":"N Gurvich","year":"2005","journal-title":"FASEB J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1126\/science.1065329","article-title":"An extensive class of small RNAs in Caenorhabditis elegans","volume":"294","author":"RC Lee","year":"2001","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/dna.2006.0545","article-title":"Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny","volume":"26","author":"C-T Lee","year":"2007","journal-title":"DNA and Cell Biology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00412-009-0210-z","article-title":"An elegant miRror: microRNAs in stem cells, developmental timing and cancer","volume":"118","author":"RA Nimmo","year":"2009","journal-title":"Chromosoma"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35040556","article-title":"Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA","volume":"408","author":"AE Pasquinelli","year":"2000","journal-title":"Nature"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing","volume":"129","author":"P Landgraf","year":"2007","journal-title":"Cell"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/gb-2004-5-3-r13","article-title":"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation","volume":"5","author":"LF Sempere","year":"2004","journal-title":"Genome Biol"},{"key":"ref63","first-page":"682","article-title":"MicroRNA-206: the skeletal muscle-specific myomiR","volume":"1779","author":"JJ McCarthy","year":"2008","journal-title":"BiochimBiophysActa"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"14931","DOI":"10.1523\/JNEUROSCI.4280-10.2010","article-title":"MicroRNA Regulation of Neural Stem Cells and Neurogenesis","volume":"30","author":"Y Shi","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.200603008","article-title":"Muscle-specific microRNA miR-206 promotes muscle differentiation","volume":"174","author":"HK Kim","year":"2006","journal-title":"The Journal of Cell Biology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"13805","DOI":"10.1074\/jbc.M110.192625","article-title":"TGF- Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4","volume":"286","author":"CE Winbanks","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"ref67","unstructured":"Goljanek-Whysalla K, Dylan Sweetmana, Abu-Elmagda M, Chapnikc E, Dalmayb T, et al. (2011) MicroRNA regulation of the paired-box transcriptionfactor Pax3 confers robustness to developmentaltiming of myogenesis: PNAS 1\u20136. doi:10.1073\/pnas.1105362108\/-\/DCSupplemental."},{"key":"ref68","first-page":"203","article-title":"miR-206 and -486 induce myoblast differentiation by downregulating Pax7","volume":"31","author":"BK Dey","year":"2011","journal-title":"MolCell Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1181046","article-title":"MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice","volume":"326","author":"AH Williams","year":"2009","journal-title":"Science"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1093\/nar\/gkl743","article-title":"MIR-206 regulates connexin43 expression during skeletal muscle development","volume":"34","author":"C Anderson","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref71","first-page":"659","article-title":"Homeobox genes and congenital malformations","volume":"66","author":"RW Redline","year":"1992","journal-title":"Lab Invest"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1074\/jbc.M109.095612","article-title":"miR-10a Contributes to Retinoid Acid-induced Smooth Muscle Cell Differentiation","volume":"285","author":"H Huang","year":"2010","journal-title":"Journal of Biological Chemistry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1074\/jbc.M110.167817","article-title":"MicroRNAs-10a and -10b contribute to retinoic acid-induced differentiation of neuroblastoma cells and target the alternative splicing regulatory factor SFRS1 (SF2\/ASF)","volume":"286","author":"S Meseguer","year":"2011","journal-title":"J Biol Chem"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbrc.2011.10.036","article-title":"Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressors","volume":"414","author":"H Hagiwara","year":"2011","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"7757","DOI":"10.1073\/pnas.112218599","article-title":"Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases","volume":"99","author":"S Iezzi","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref76","first-page":"491","article-title":"Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133","volume":"321","author":"D Sweetman","year":"2008","journal-title":"DevBiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1038\/onc.2010.111","article-title":"TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2\/214","volume":"29","author":"G Yin","year":"2010","journal-title":"Oncogene"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/nar\/gkn920","article-title":"Twist-1 regulates the miR-199a\/214 cluster during development","volume":"37","author":"YB Lee","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","article-title":"Biomarkers for epithelial-mesenchymal transitions","volume":"119","author":"M Zeisberg","year":"2009","journal-title":"J Clin Invest"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1119(01)00893-9","article-title":"A Twist in fate: evolutionary comparison of Twist structure and function","volume":"287","author":"I Castanon","year":"2002","journal-title":"Gene"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1953","article-title":"Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate","volume":"39","author":"AS Flynt","year":"2007","journal-title":"Nat Genet"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/cbf.1760","article-title":"Inhibition of miR-214 expression represses proliferation and differentiation of C2C12 myoblasts","volume":"29","author":"Y Feng","year":"2011","journal-title":"Cell Biochem Funct"},{"key":"ref83","first-page":"61","article-title":"Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells","volume":"36","author":"AH Juan","year":"2009","journal-title":"MolCell"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"26599","DOI":"10.1074\/jbc.M110.115824","article-title":"MicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-ras","volume":"285","author":"J Liu","year":"2010","journal-title":"J Biol Chem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1096\/fj.09-152207","article-title":"miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells","volume":"24","author":"C Tarantino","year":"2010","journal-title":"FASEB J"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7015-6-14","article-title":"miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells","volume":"6","author":"J Silber","year":"2008","journal-title":"BMC Med"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1083\/jcb.200908151","article-title":"Cross talk between microRNA and epigenetic regulation in adult neurogenesis","volume":"189","author":"KE Szulwach","year":"2010","journal-title":"The Journal of Cell Biology"},{"key":"ref88","first-page":"500","article-title":"Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay","volume":"42","author":"IG Bruno","year":"2011","journal-title":"MolCell"},{"key":"ref89","first-page":"4197","article-title":"miR-375 inhibits differentiation of neurites by lowering HuD levels","volume":"30","author":"K Abdelmohsen","year":"2010","journal-title":"MolCell Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1093\/hmg\/dds239","article-title":"Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome","volume":"21","author":"NV Balmer","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-012-0967-3","article-title":"Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach","volume":"87","author":"AK Krug","year":"2012","journal-title":"Arch Toxicol"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"Balmer NV, leist M (2014) Epigenetics and Transcriptomics to Detect Adverse Drug Effects in Model Systems of Human Development. Basic Clin Pharmacol Toxicol. doi:10.1111\/bcpt.12203.","DOI":"10.1111\/bcpt.12203"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1021\/tx400402j","article-title":"Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells","volume":"27","author":"T Waldmann","year":"2014","journal-title":"Chem Res Toxicol"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/toxsci\/kfr070","article-title":"Short-Time Gene Expression Response to Valproic Acid and Valproic Acid Analogs in Mouse Embryonic Stem Cells","volume":"121","author":"M Jergil","year":"2011","journal-title":"Toxicol Sci"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"S Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Research"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0098892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T23:17:23Z","timestamp":1649200643000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0098892"}},"subtitle":[],"editor":[{"given":"Maurilio","family":"Sampaolesi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0098892","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}