{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:29:28Z","timestamp":1784194168554,"version":"3.55.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0099381","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T05:59:58Z","timestamp":1404280798000},"page":"e99381","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Safety and Immunogenicity of a Live Oral Recombinant Cholera Vaccine VA1.4: A Randomized, Placebo Controlled Trial in Healthy Adults in a Cholera Endemic Area in Kolkata, India"],"prefix":"10.1371","volume":"9","clinical-trial-number":[{"clinical-trial-number":"ctri\/2012\/04\/002582","registry":"10.18810\/clinical-trial-registry-india"}],"author":[{"given":"Suman","family":"Kanungo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandana","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thandavarayan","family":"Ramamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Sur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byomkesh","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gururaja P.","family":"Pazhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goutam","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Jhunjhunwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan K.","family":"Nandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemanta","family":"Koley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir Kumar","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Goel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thungapathra","family":"M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Balakrish","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Mahalanabis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"ref1","first-page":"117","article-title":"WHO, No. 13","volume":"85","author":"Record Weekly epidemiological","year":"2010"},{"key":"ref2","first-page":"321","article-title":"WHO, No. 31","volume":"88","author":"record Weekly epidemiological","year":"2013"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0165-2478(99)00076-0","article-title":"Construction of a recombinant live oral vaccine from a non-toxigenic strain of Vibrio cholera O1 serotype inaba biotype E1 Tor and assessment of its reactogenicity and immunogenicity in the rabbit model","volume":"68","author":"M Thungapathra","year":"1999","journal-title":"Immunol Lett"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1016\/j.vaccine.2009.05.065","article-title":"Randomized placebo controlled human volunteer trial of a live oral cholera vaccine VA 1.3 for safety and immune response","volume":"27","author":"D Mahalanabis","year":"2009","journal-title":"Vaccine"},{"key":"ref5","first-page":"277","article-title":"Serological Studies in cholera. 2. The vibriocidal antibody response of cholera patients determined by a microtechnique","volume":"38","author":"As Benenson","year":"1968","journal-title":"Bull World Health Organ"},{"key":"ref6","first-page":"1137","article-title":"Serum antibacterial and antitoxin responses in clinical cholera caused by Vibrio cholera O139 Bengal and evaluation of their importance in protection Vaccine","volume":"14","author":"RK Nandy","year":"1996"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0014-5793(93)81136-N","article-title":"Identification of toxigenic Vibrio cholerae from the Argentine outbreak by PCR for ctx A1 and ctx A2-B","volume":"315","author":"P Varela","year":"1993","journal-title":"FEBS Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e2323","DOI":"10.1371\/journal.pone.0002323","article-title":"A randomized placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India","volume":"3","author":"D Mahalanabis","year":"2008","journal-title":"PLoS One"},{"key":"ref9","unstructured":"Qadri F, Chowdhury MI, Faruque SM, Salam MA, Ahmed T, <etal>et al<\/etal>.. (2005) Peru-15 Study Group. Randomized, controlled study of the safety and immunogenicity of Peru-15, a live attenuated oral vaccine candidate for cholera, in adult volunteers in Bangladesh. J Infect Dis. 15; 192(4): 573\u20139. Epub 2005 Jul 15."},{"key":"ref10","first-page":"986","article-title":"A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh. Pediatr Infect Dis J","volume":"27(11)","author":"F Chowdhury","year":"2008"},{"key":"ref11","first-page":"777","article-title":"The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients","volume":"38","author":"WH Mosley","year":"1968","journal-title":"Bull World Health Organ"},{"key":"ref12","first-page":"327","article-title":"A serological survey for cholera antibodies in rural east Pakistan 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera","volume":"38","author":"WH Mosley","year":"1968","journal-title":"Bull World Health Organ"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/JB.100.1.547-549.1969","article-title":"Active and passive immunization in the adult rabbit ileal loop model as an assay for production of antitoxin immunity by cholera vaccines","volume":"100","author":"WH Mosley","year":"1969","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/infdis\/151.2.236","article-title":"Seroepidemiological studies of El Tor cholera in Bangladesh: association of serum antibody levels with protection","volume":"151","author":"RI Glass","year":"1985","journal-title":"J Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/infdis\/163.6.1235","article-title":"Field trial of oral cholera vaccines in Bangladesh: serum vibriocidal and antitoxic antibodies as markers of the risk of cholera","volume":"163","author":"JD Clemens","year":"1991","journal-title":"J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0264-410X(93)90019-T","article-title":"Live oral vaccines against cholera: an update","volume":"11","author":"MM Levine","year":"1993","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Levine MM, Pierce NF (1992) Immunity and vaccine development. In: Greenough III WB, Barua D, editors. Cholera. New York: Plenum Publishing Corporation 285\u2013327.","DOI":"10.1007\/978-1-4757-9688-9_14"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1086\/421275","article-title":"Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholera infection in urban Bangladesh","volume":"189","author":"D Saha","year":"2004","journal-title":"J Infec Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/infdis\/125.6.647","article-title":"Antitoxic immunity in experimental cholera: comparison of immunity induced perorally and parenterally in mice","volume":"125","author":"K Fujita","year":"1972","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1128\/IAI.12.6.1331-1340.1975","article-title":"Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization","volume":"12","author":"J Holmgren","year":"1975","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/infdis\/135.6.888","article-title":"Immunity to experimental cholera. III. Enhanced duration of protection after sequential parenteral-oral toxoid administration to dogs","volume":"135","author":"NF Pierce","year":"1977","journal-title":"J Infect Dis"},{"key":"ref22","first-page":"1017","article-title":"Immunity to experimental cholera. I. Protective effect of humoral IgG antitoxin demonstrated by passive immunization","volume":"113","author":"NF Pierce","year":"1974","journal-title":"J Immunol"},{"key":"ref23","first-page":"594","article-title":"Protection against experimental cholera by oral or parenteral immunization, Infect Immun","volume":"26","author":"JW Peterson","year":"1979"},{"key":"ref24","unstructured":"Noriki H (1976) Evaluation of toxic field trial on the Philippines, in Fukumi H, Zinnaka Y (eds): Proceedings of the 12<sup>th<\/sup> Joint Conference on Cholera, U.S.- Japan Cooperative Medical Science Program. Sapporo. Fuji, Tokyo 302\u201310."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jinf.2007.07.020","article-title":"Molecular characterization of recent Vibrio Cholerae O1, El TOR, Inaba strains isolated from hospitalized patients in Kolkata, India","volume":"55","author":"A Raychoudhuri","year":"2007","journal-title":"J Infect"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0099381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T21:44:58Z","timestamp":1598046298000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0099381"}},"subtitle":[],"editor":[{"given":"D.","family":"William Cameron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":25,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0099381","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}