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Globocan 2012, Cancer Fact Sheet. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx\" xlink:type=\"simple\">http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx<\/ext-link>. Accessed 2014 Mar 12."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3513S","DOI":"10.1093\/jn\/134.12.3513S","article-title":"Diet and cancer prevention: evidence-based medicine to genomic medicine","volume":"134","author":"VLW Go","year":"2004","journal-title":"J Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"iv249","DOI":"10.1093\/annonc\/mdh935","article-title":"Cancer prevention in the political arena: the WHO perspective","volume":"15","author":"A Ullrich","year":"2004","journal-title":"Ann Oncol Off J Eur Soc Med Oncol ESMO"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1073\/pnas.89.6.2399","article-title":"A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure","volume":"89","author":"Y Zhang","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.canlet.2008.04.018","article-title":"Multi-targeted prevention of cancer by sulforaphane","volume":"269","author":"JD Clarke","year":"2008","journal-title":"Cancer Lett"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00018-007-6484-5","article-title":"Molecular basis for chemoprevention by sulforaphane: a comprehensive review","volume":"64","author":"N Juge","year":"2007","journal-title":"Cell Mol Life Sci CMLS"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Y-J Surh","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/tx0502138","article-title":"Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane","volume":"18","author":"F Hong","year":"2005","journal-title":"Chem Res Toxicol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.canlet.2005.11.050","article-title":"Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL\/6J mice and C57BL\/6J\/Nrf2 (\u2212\/\u2212) mice","volume":"243","author":"R Hu","year":"2006","journal-title":"Cancer Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.2011.06092.x","article-title":"Regulation of the Keap1\/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications","volume":"1229","author":"Y-S Keum","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9590","DOI":"10.1073\/pnas.1004104107","article-title":"Electrophilic tuning of the chemoprotective natural product sulforaphane","volume":"107","author":"Y-H Ahn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/carcin\/22.3.425","article-title":"Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates","volume":"22","author":"Y Zhang","year":"2001","journal-title":"Carcinogenesis"},{"key":"ref13","unstructured":"U.S. National Institutes of Health. ClinicalTrials.gov, search of sulforaphane. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/results?term=sulforaphane&Search=Search\" xlink:type=\"simple\">http:\/\/clinicaltrials.gov\/ct2\/results?term=sulforaphane&amp;Search=Search<\/ext-link>. Accessed 2014 Mar 12."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.semcancer.2007.04.001","article-title":"Dietary histone deacetylase inhibitors: from cells to mice to man","volume":"17","author":"RH Dashwood","year":"2007","journal-title":"Semin Cancer Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.3945\/jn.109.113332","article-title":"Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention","volume":"139","author":"E Ho","year":"2009","journal-title":"J Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.4155\/fmc.12.3","article-title":"Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed","volume":"4","author":"BE Gryder","year":"2012","journal-title":"Future Med Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1158\/0008-5472.CAN-04-1326","article-title":"A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase","volume":"64","author":"MC Myzak","year":"2004","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/carcin\/bgi265","article-title":"Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells","volume":"27","author":"MC Myzak","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref19","first-page":"227","article-title":"Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects","volume":"232","author":"MC Myzak","year":"2007","journal-title":"Exp Biol Med Maywood NJ"},{"key":"ref20","first-page":"506","article-title":"Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice","volume":"20","author":"MC Myzak","year":"2006","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1128\/MCB.23.12.4162-4173.2003","article-title":"Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5","volume":"23","author":"A Rascle","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1359-6101(99)00011-8","article-title":"Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation","volume":"10","author":"PM Grimley","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1002\/j.1460-2075.1994.tb06495.x","article-title":"Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response","volume":"13","author":"H Wakao","year":"1994","journal-title":"EMBO J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1093\/nar\/gkn271","article-title":"In vivo identification of novel STAT5 target genes","volume":"36","author":"B Basham","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4754","DOI":"10.1093\/emboj\/18.17.4754","article-title":"STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells","volume":"18","author":"T Nosaka","year":"1999","journal-title":"EMBO J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/j.1460-2075.1996.tb00600.x","article-title":"Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation","volume":"15","author":"AL Mui","year":"1996","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molcel.2011.12.026","article-title":"SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation","volume":"45","author":"T Van Nguyen","year":"2012","journal-title":"Mol Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e26102","DOI":"10.4161\/jkst.26102","article-title":"STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis","volume":"2","author":"C Kosan","year":"2013","journal-title":"JAK-STAT"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"19314","DOI":"10.1073\/pnas.1010253107","article-title":"Acetylation modulates prolactin receptor dimerization","volume":"107","author":"L Ma","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1038\/sj.onc.1203522","article-title":"Modulation of STAT signaling by STAT-interacting proteins","volume":"19","author":"K Shuai","year":"2000","journal-title":"Oncogene"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.immuni.2012.02.017","article-title":"Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function","volume":"36","author":"J-X Lin","year":"2012","journal-title":"Immunity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/ni.2136","article-title":"Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2","volume":"12","author":"M Mandal","year":"2011","journal-title":"Nat Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"45340","DOI":"10.1074\/jbc.M303644200","article-title":"NCoA-1\/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain","volume":"278","author":"CM Litterst","year":"2003","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1210\/mend.12.10.0180","article-title":"p300\/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response","volume":"12","author":"E Pfitzner","year":"1998","journal-title":"Mol Endocrinol Baltim Md"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1182\/blood.V95.1.19","article-title":"The Jak-Stat pathway in normal and perturbed hematopoiesis","volume":"95","author":"AC Ward","year":"2000","journal-title":"Blood"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bcp.2005.12.017","article-title":"JAK\/STAT signal transduction: regulators and implication in hematological malignancies","volume":"71","author":"L Valentino","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/sj.onc.1203527","article-title":"STATs in oncogenesis","volume":"19","author":"T Bowman","year":"2000","journal-title":"Oncogene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6342","DOI":"10.1074\/jbc.274.10.6342","article-title":"Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA\/F3 cells","volume":"274","author":"CB Liu","year":"1999","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1182\/blood-2003-06-2007","article-title":"SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak\/STAT pathway","volume":"103","author":"C-S Chim","year":"2004","journal-title":"Blood"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"14133","DOI":"10.1073\/pnas.2232790100","article-title":"SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer","volume":"100","author":"B He","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1038\/sj.onc.1208788","article-title":"Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK\/STAT and FAK signalings in human hepatocellular carcinoma","volume":"24","author":"Y Niwa","year":"2005","journal-title":"Oncogene"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1038\/sj.onc.1208818","article-title":"SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition","volume":"24","author":"A Weber","year":"2005","journal-title":"Oncogene"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1073\/pnas.0501959102","article-title":"STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes","volume":"102","author":"Q Zhang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"518","DOI":"10.18632\/oncotarget.296","article-title":"A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation","volume":"2","author":"EA Nelson","year":"2011","journal-title":"Oncotarget"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1359-6446(03)03014-9","article-title":"Inhibitors of JAKs\/STATs and the kinases: a possible new cluster of drugs","volume":"9","author":"C Luo","year":"2004","journal-title":"Drug Discov Today"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood-2013-02-485573","article-title":"JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia","volume":"122","author":"W Warsch","year":"2013","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1158\/1078-0432.CCR-12-0284","article-title":"Molecular pathways: Jak\/STAT pathway: mutations, inhibitors, and resistance","volume":"19","author":"A Quint\u00e1s-Cardama","year":"2013","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.bcp.2013.08.009","article-title":"Sophoraflavanone G induces apoptosis of human cancer cells by targeting upstream signals of STATs","volume":"86","author":"B-H Kim","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1038\/bcj.2013.6","article-title":"Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F","volume":"3","author":"L Ma","year":"2013","journal-title":"Blood Cancer J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"10090","DOI":"10.1021\/jm3012239","article-title":"Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors","volume":"55","author":"EJ Hanan","year":"2012","journal-title":"J Med Chem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e37207","DOI":"10.1371\/journal.pone.0037207","article-title":"Efficacious intermittent dosing of a novel JAK2 inhibitor in mouse models of polycythemia vera","volume":"7","author":"M Kraus","year":"2012","journal-title":"PloS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1158\/1535-7163.MCT-10-0416","article-title":"AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells","volume":"9","author":"J Yang","year":"2010","journal-title":"Mol Cancer Ther"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/jm1011319","article-title":"Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak\/Stat pathway","volume":"54","author":"S Ioannidis","year":"2011","journal-title":"J Med Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/1947601910371337","article-title":"A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition","volume":"1","author":"SS Jatiani","year":"2010","journal-title":"Genes Cancer"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.blre.2010.10.004","article-title":"JAK2 inhibitors: what&apos;s the true therapeutic potential?","volume":"25","author":"FPS Santos","year":"2011","journal-title":"Blood Rev"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e90275","DOI":"10.1371\/journal.pone.0090275","article-title":"The Synthetic \u03b1-Bromo-2\u2032,3,4,4\u2032-Tetramethoxychalcone (\u03b1-Br-TMC) Inhibits the JAK\/STAT Signaling Pathway","volume":"9","author":"S Pinz","year":"2014","journal-title":"PloS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"30837","DOI":"10.1074\/jbc.270.52.30837","article-title":"JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase\/mitogen-activated protein kinase by growth hormone","volume":"270","author":"LA Winston","year":"1995","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1074\/jbc.274.9.5333","article-title":"Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase","volume":"274","author":"A Al-Shami","year":"1999","journal-title":"J Biol Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/cbic.200700701","article-title":"Discovery of chromone-based inhibitors of the transcription factor STAT5","volume":"9","author":"J M\u00fcller","year":"2008","journal-title":"Chembiochem Eur J Chem Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ab.2008.01.017","article-title":"A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization","volume":"375","author":"J M\u00fcller","year":"2008","journal-title":"Anal Biochem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e166","DOI":"10.1038\/bcj.2013.63","article-title":"A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases","volume":"3","author":"F Hayakawa","year":"2013","journal-title":"Blood Cancer J"},{"key":"ref62","first-page":"960","article-title":"The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells","volume":"6","author":"A Weber","year":"2013","journal-title":"Pharm Basel Switz"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1182\/blood-2009-11-255232","article-title":"The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors","volume":"117","author":"EA Nelson","year":"2011","journal-title":"Blood"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1947601912466555","article-title":"The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations","volume":"3","author":"EA Nelson","year":"2012","journal-title":"Genes Cancer"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1093\/nar\/gkg907","article-title":"Chromatin acetylation and remodeling at the Cis promoter during STAT5-induced transcription","volume":"31","author":"A Rascle","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1182\/blood.V45.3.321.321","article-title":"Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome","volume":"45","author":"CB Lozzio","year":"1975","journal-title":"Blood"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0092-8674(85)80053-2","article-title":"Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo","volume":"41","author":"R Palacios","year":"1985","journal-title":"Cell"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1128\/MCB.18.7.3871","article-title":"Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation","volume":"18","author":"M Onishi","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yexcr.2008.10.012","article-title":"The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes","volume":"315","author":"A Rascle","year":"2009","journal-title":"Exp Cell Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S1097-2765(00)00067-8","article-title":"Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL\/JAK2","volume":"6","author":"J Schwaller","year":"2000","journal-title":"Mol Cell"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1182\/blood.V94.3.1108.415k07_1108_1112","article-title":"STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells","volume":"94","author":"RP De Groot","year":"1999","journal-title":"Blood"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1084\/jem.189.8.1229","article-title":"Signal transducer and activator of transcription (STAT)5 activation by BCR\/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR\/ABL and is required for leukemogenesis","volume":"189","author":"M Nieborowska-Skorska","year":"1999","journal-title":"J Exp Med"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"31704","DOI":"10.1074\/jbc.271.49.31704","article-title":"P210 and P190(BCR\/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members","volume":"271","author":"RL Ilaria Jr","year":"1996","journal-title":"J Biol Chem"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbrc.2003.08.055","article-title":"STI-571: an anticancer protein-tyrosine kinase inhibitor","volume":"309","author":"R Roskoski Jr","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref75","first-page":"3659","article-title":"Lipopolysaccharide-induced desensitization of junB gene expression in a mouse macrophage-like cell line, P388D1","volume":"161","author":"M Fujihara","year":"1998","journal-title":"J Immunol Baltim Md 1950"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1042\/BST20110636","article-title":"Immediate-early gene activation by the MAPK pathways: what do and don&apos;t we know?","volume":"40","author":"A O'Donnell","year":"2012","journal-title":"Biochem Soc Trans"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1182\/blood.V89.9.3148","article-title":"CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation","volume":"89","author":"A Matsumoto","year":"1997","journal-title":"Blood"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/j.1460-2075.1996.tb00443.x","article-title":"Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway","volume":"15","author":"A Yoshimura","year":"1996","journal-title":"EMBO J"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/emboj.2013.138","article-title":"A new player in Pol II pausing","volume":"32","author":"NJ Fuda","year":"2013","journal-title":"EMBO J"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrg3293","article-title":"Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans","volume":"13","author":"K Adelman","year":"2012","journal-title":"Nat Rev Genet"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.celrep.2012.08.034","article-title":"Defining the status of RNA polymerase at promoters","volume":"2","author":"LJ Core","year":"2012","journal-title":"Cell Rep"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1101\/gad.1235904","article-title":"Elongation by RNA polymerase II: the short and long of it","volume":"18","author":"RJ Sims 3rd","year":"2004","journal-title":"Genes Dev"},{"key":"ref83","first-page":"411","article-title":"Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner","volume":"184","author":"HS Youn","year":"2010","journal-title":"J Immunol Baltim Md 1950"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/en.2008-1241","article-title":"S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling","volume":"150","author":"Y Xie","year":"2009","journal-title":"Endocrinology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.lfs.2006.12.040","article-title":"Chalcone inhibits the activation of NF-kappaB and STAT3 in endothelial cells via endogenous electrophile","volume":"80","author":"Y-C Liu","year":"2007","journal-title":"Life Sci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e20174","DOI":"10.1371\/journal.pone.0020174","article-title":"Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation","volume":"6","author":"E Butturini","year":"2011","journal-title":"PloS One"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Butturini E, de Prati AC, Chiavegato G, Rigo A, Cavalieri E, <etal>et al<\/etal>.. (2013) Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoral cells to chemotherapeutic drugs. Free Radic Biol Med.","DOI":"10.1016\/j.freeradbiomed.2013.09.015"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/pros.20869","article-title":"Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells","volume":"69","author":"S Bhamre","year":"2009","journal-title":"The Prostate"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1023\/B:PHAM.0000022412.69380.d7","article-title":"Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line","volume":"21","author":"W-S Jeong","year":"2004","journal-title":"Pharm Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1207\/s15327914nc5202_11","article-title":"Involvement of c-Jun N-terminal kinase in G2\/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells","volume":"52","author":"S-D Cho","year":"2005","journal-title":"Nutr Cancer"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.bcp.2005.03.015","article-title":"Role of PI3K\/Akt and MEK\/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2\/M arrest and cell death in Caco-2 cells","volume":"69","author":"J Jakub\u00edkov\u00e1","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/carcin\/bgi251","article-title":"ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells","volume":"27","author":"C Xu","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1158\/0008-5472.CAN-05-3513","article-title":"Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells","volume":"66","author":"Y-S Keum","year":"2006","journal-title":"Cancer Res"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0027-5107(01)00182-8","article-title":"Signal transduction events elicited by cancer prevention compounds","volume":"480\u2013481","author":"AN Kong","year":"2001","journal-title":"Mutat Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/nar\/19.4.775","article-title":"Activation of junB by PKC and PKA signal transduction through a novel cis-acting element","volume":"19","author":"RP De Groot","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1016\/S0021-9258(19)85264-X","article-title":"Two cis-regulatory elements that mediate different signaling pathways for serum-dependent activation of the junB gene","volume":"268","author":"I Kitabayashi","year":"1993","journal-title":"J Biol Chem"},{"key":"ref97","first-page":"2353","article-title":"Quantitative analysis of the contribution made by 5\u2032-flanking and 3\u2032-flanking sequences to the transcriptional regulation of junB by growth factors","volume":"9","author":"DG Phinney","year":"1994","journal-title":"Oncogene"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"21145","DOI":"10.1074\/jbc.273.33.21145","article-title":"Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer","volume":"273","author":"LJ Jonk","year":"1998","journal-title":"J Biol Chem"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-5793(02)02295-0","article-title":"NF-kappaB elements contribute to junB inducibility by lipopolysaccharide in the murine macrophage cell line RAW264.7","volume":"513","author":"MR Frazier-Jessen","year":"2002","journal-title":"FEBS Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0099391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T05:56:30Z","timestamp":1649310990000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0099391"}},"subtitle":[],"editor":[{"given":"Michael","family":"Nevels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,9]]},"references-count":99,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0099391","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,9]]}}}