{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:34:00Z","timestamp":1792532040024,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0099453","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T20:42:17Z","timestamp":1402346537000},"page":"e99453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Protective Effect of the HLA-DRB1*13:02 Allele in Japanese Rheumatoid Arthritis Patients"],"prefix":"10.1371","volume":"9","author":[{"given":"Shomi","family":"Oka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Sugii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoshi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Saisho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Migita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhei","family":"Nagaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeto","family":"Tohma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.autrev.2011.04.021","article-title":"An overview on the genetic of rheumatoid arthritis: a never-ending story","volume":"10","author":"C Perricone","year":"2011","journal-title":"Autoimmun Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.berh.2011.10.010","article-title":"Precipitating and perpetuating factors of rheumatoid arthritis immunopathology: linking the triad of genetic predisposition, environmental risk factors and autoimmunity to disease pathogenesis","volume":"25","author":"IC Scott","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e27175","DOI":"10.1371\/journal.pone.0027175","article-title":"Prediction of disease and phenotype associations from genome-wide association studies","volume":"6","author":"SN Lewis","year":"2011","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00002281-199805000-00007","article-title":"The genetic contribution to the pathogenesis of rheumatoid arthritis","volume":"10","author":"JD Reveille","year":"1998","journal-title":"Curr Opin Rheumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/BOR.0b013e328336ba63","article-title":"The rheumatoid arthritis HLA-DRB1 shared epitope","volume":"22","author":"J Holoshitz","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0198-8859(98)00101-3","article-title":"HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis","volume":"60","author":"IE van der Horst-Bruinsma","year":"1999","journal-title":"Hum Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/art.10210","article-title":"Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67\u201374 of the HLA-DRB1 molecule","volume":"46","author":"N de Vries","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref8","first-page":"232","article-title":"HLA-DRB1 alleles encoding an aspartic acid at position 70 protect against development of rheumatoid arthritis","volume":"28","author":"DL Mattey","year":"2001","journal-title":"J Rheumatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1186\/ar2131","article-title":"A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis","volume":"9","author":"PA Gourraud","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1136\/ard.2007.075382","article-title":"Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection","volume":"67","author":"D Mewar","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/art.24410","article-title":"Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis","volume":"60","author":"E Lundstrom","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/art.27366","article-title":"Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations","volume":"62","author":"D van der Woude","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/rheumatology\/36.6.630","article-title":"The relationship between HLA-DRB1 alleles and disease subsets of rheumatoid arthritis in Japanese","volume":"36","author":"S Wakitani","year":"1997","journal-title":"Br J Rheumatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/1529-0131(200004)43:4<753::AID-ANR5>3.0.CO;2-O","article-title":"Tumor necrosis factor alpha 5\u2032-flanking region, tumor necrosis factor receptor II, and HLA-DRB1 polymorphisms in Japanese patients with rheumatoid arthritis","volume":"43","author":"T Shibue","year":"2000","journal-title":"Arthritis Rheum"},{"key":"ref15","first-page":"674","article-title":"Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese","volume":"34","author":"SC Liu","year":"2007","journal-title":"J Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-0039.2012.01872.x","article-title":"Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis","volume":"80","author":"S Mitsunaga","year":"2012","journal-title":"Tissue Antigens"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/rheumatology\/kes427","article-title":"An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes","volume":"52","author":"K Shimane","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"ref18","first-page":"71","article-title":"Establishment of B-cell lines derived from 996 Japanese individuals","volume":"23","author":"N Kamatani","year":"2004","journal-title":"Tissue Culture Res Commun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/art.20989","article-title":"New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility","volume":"52","author":"ST du Montcel","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e33133","DOI":"10.1371\/journal.pone.0033133","article-title":"Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: A protective role for shared epitope","volume":"7","author":"H Furukawa","year":"2012","journal-title":"PLoS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e53910","DOI":"10.1371\/journal.pone.0053910","article-title":"Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro\/SS-A and anti-La\/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosus patients","volume":"8","author":"H Furukawa","year":"2013","journal-title":"PLoS ONE"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/annrheumdis-2012-201944","article-title":"HLA-A*31:01 and methotrexate-induced interstitial lung aisease in Japanese rheumatoid arthritis patients: A multi-drug hypersensitivity marker","volume":"72","author":"H Furukawa","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1471-8286.2007.01931.x","article-title":"genepop&apos;007: a complete re-implementation of the genepop software for Windows and Linux","volume":"8","author":"F Rousset","year":"2008","journal-title":"Mol Ecol Resour"},{"key":"ref25","first-page":"541","article-title":"Relative predispositional effects (RPEs) of marker alleles with disease: HLA-DR alleles and Graves disease","volume":"45","author":"H Payami","year":"1989","journal-title":"Am J Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1001\/jama.1949.02900430001001","article-title":"Therapeutic criteria in rheumatoid arthritis","volume":"140","author":"O Steinbrocker","year":"1949","journal-title":"J Am Med Assoc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e46806","DOI":"10.1371\/journal.pone.0046806","article-title":"Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04:01 in Japanese population","volume":"7","author":"M Kawashima","year":"2012","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1158\/0008-5472.CAN-07-6471","article-title":"Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk","volume":"68","author":"MM Madeleine","year":"2008","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e78699","DOI":"10.1371\/journal.pone.0078699","article-title":"Rates of serious intracellular infections in autoimmune disease patients receiving initial glucocorticoid therapy","volume":"8","author":"K Migita","year":"2013","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/ng.348","article-title":"A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians","volume":"41","author":"Y Kamatani","year":"2009","journal-title":"Nat Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e40067","DOI":"10.1371\/journal.pone.0040067","article-title":"ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese","volume":"7","author":"C Terao","year":"2012","journal-title":"PLoS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/368711a0","article-title":"Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen","volume":"368","author":"TS Jardetzky","year":"1994","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"S Raychaudhuri","year":"2012","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0099453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T01:05:07Z","timestamp":1540256707000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0099453"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,9]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0099453","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,9]]}}}