{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:37:53Z","timestamp":1791419873527,"version":"4.3.3"},"reference-count":101,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0099509","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T20:37:05Z","timestamp":1402087025000},"page":"e99509","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genomics of Post-Prandial Lipidomic Phenotypes in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study"],"prefix":"10.1371","volume":"9","author":[{"given":"Marguerite R.","family":"Irvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Degui","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Aslibekyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Claas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin M.","family":"Absher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Ordovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant K.","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna K.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/CIRCULATIONAHA.106.637793","article-title":"Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies","volume":"115","author":"N Sarwar","year":"2007","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1017\/S000711450774268X","article-title":"Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism","volume":"98","author":"J Lopez-Miranda","year":"2007","journal-title":"Br J Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCULATIONAHA.108.777334","article-title":"Fasting compared with nonfasting lipids and apolipoproteins for predicting incident cardiovascular events","volume":"118","author":"S Mora","year":"2008","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jama.1996.03540110036029","article-title":"A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction","volume":"276","author":"MJ Stampfer","year":"1996","journal-title":"Jama"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.298.3.299","article-title":"Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women","volume":"298","author":"BG Nordestgaard","year":"2007","journal-title":"Jama"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2796.2010.02333.x","article-title":"Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up","volume":"270","author":"A Langsted","year":"2011","journal-title":"J Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"576","DOI":"10.7326\/0003-4819-121-8-199410150-00004","article-title":"Postprandial triglyceride response in young adult men and familial risk for coronary atherosclerosis","volume":"121","author":"CS Uiterwaal","year":"1994","journal-title":"Ann Intern Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1046\/j.1365-2362.2000.00674.x","article-title":"Postprandial response to a fat tolerance test in young adults with a paternal history of premature coronary heart disease - the EARS II study (European Atherosclerosis Research Study)","volume":"30","author":"L Tiret","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/eurheartj\/ehr112","article-title":"Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management","volume":"32","author":"MJ Chapman","year":"2011","journal-title":"Eur Heart J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3945\/ajcn.2008.26363","article-title":"Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states","volume":"89","author":"P Perez-Martinez","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00439-009-0700-3","article-title":"Glucokinase regulatory protein gene polymorphism affects postprandial lipemic response in a dietary intervention study","volume":"126","author":"H Shen","year":"2009","journal-title":"Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/msb.2009.11","article-title":"High heritability of metabolomic profiles in families burdened with premature cardiovascular disease","volume":"5","author":"SH Shah","year":"2009","journal-title":"Mol Syst Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1000672","DOI":"10.1371\/journal.pgen.1000672","article-title":"Genetic determinants of circulating sphingolipid concentrations in European populations","volume":"5","author":"AA Hicks","year":"2009","journal-title":"PLoS Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1373\/clinchem.2011.169573","article-title":"Metabolomics and cardiovascular biomarker discovery","volume":"58","author":"EP Rhee","year":"2012","journal-title":"Clin Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1186\/gb-2011-12-1-r10","article-title":"DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines","volume":"12","author":"JT Bell","year":"2011","journal-title":"Genome Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1373\/clinchem.2006.084863","article-title":"The -256T&gt;C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study","volume":"53","author":"D Corella","year":"2007","journal-title":"Clin Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/CIRCGENETICS.110.950667","article-title":"Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study","volume":"3","author":"MR Irvin","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1161\/01.ATV.12.11.1336","article-title":"Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state","volume":"12","author":"JR Patsch","year":"1992","journal-title":"Arterioscler Thromb"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.atherosclerosis.2008.08.005","article-title":"Smoking, inflammatory patterns and postprandial hypertriglyceridemia","volume":"203","author":"EK Kabagambe","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/FPC.0b013e32834fdd41","article-title":"A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network","volume":"22","author":"S Aslibekyan","year":"2012","journal-title":"Pharmacogenet Genomics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"J Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/ng.237","article-title":"Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs","volume":"40","author":"JM Korn","year":"2008","journal-title":"Nat Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/ajcn\/86.5.1515","article-title":"Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells","volume":"86","author":"M Bouwens","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/1471-2164-9-262","article-title":"Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response","volume":"9","author":"M Bouwens","year":"2008","journal-title":"BMC Genomics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"25573","DOI":"10.1074\/jbc.273.40.25573","article-title":"Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages","volume":"273","author":"G Chinetti","year":"1998","journal-title":"J Biol Chem"},{"key":"ref26","first-page":"41","article-title":"Cell isolation and expansion using Dynabeads","volume":"106","author":"AA Neurauter","year":"2007","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/epi.6.6.16196","article-title":"Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome","volume":"6","author":"J Sandoval","year":"2011","journal-title":"Epigenetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1003678","DOI":"10.1371\/journal.pgen.1003678","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","volume":"9","author":"DM Absher","year":"2013","journal-title":"PLoS Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e46705","DOI":"10.1371\/journal.pone.0046705","article-title":"Heterogeneity in white blood cells has potential to confound DNA methylation measurements","volume":"7","author":"BT Adalsteinsson","year":"2012","journal-title":"PLoS ONE"},{"key":"ref30","unstructured":"Warnes GR, Bolker B, Bonebakker L, Gentleman R, Liaw WHA, et al. (2014) gplots: Various R programming tools for plotting data. 1.12.1 ed."},{"key":"ref31","article-title":"Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network","author":"S Aslibekyan","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/bioinformatics\/btr006","article-title":"Robust linear regression methods in association studies","volume":"27","author":"VM Lourenco","year":"2011","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/sj.hdy.6800717","article-title":"Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix","volume":"95","author":"J Li","year":"2005","journal-title":"Heredity (Edinb)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-59745-251-9_14","article-title":"Analysis of genomic DNA with the UCSC genome browser","volume":"537","author":"J Pevsner","year":"2009","journal-title":"Methods Mol Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"K Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e005066","DOI":"10.1161\/JAHA.112.005066","article-title":"Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in framingham offspring study participants","volume":"2","author":"NR Matthan","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1161\/01.ATV.17.10.1910","article-title":"Lovastatin decreases de novo cholesterol synthesis and LDL Apo B-100 production rates in combined-hyperlipidemic males","volume":"17","author":"M Cuchel","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1742-1241.2001.tb11168.x","article-title":"Cholesterol absorption inhibition: a strategy for cholesterol-lowering therapy","volume":"55","author":"TA Miettinen","year":"2001","journal-title":"Int J Clin Pract"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1172\/JCI113107","article-title":"Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype","volume":"80","author":"YA Kesaniemi","year":"1987","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1194\/jlr.M900032-JLR200","article-title":"Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial","volume":"51","author":"NR Matthan","year":"2010","journal-title":"J Lipid Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1194\/jlr.P900039-JLR200","article-title":"Alterations in cholesterol absorption\/synthesis markers characterize Framingham offspring study participants with CHD","volume":"50","author":"NR Matthan","year":"2009","journal-title":"J Lipid Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e13467","DOI":"10.1371\/journal.pone.0013467","article-title":"The relationships of markers of cholesterol homeostasis with carotid intima-media thickness","volume":"5","author":"O Weingartner","year":"2010","journal-title":"PLoS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1194\/jlr.P002899","article-title":"The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality","volume":"51","author":"G Silbernagel","year":"2010","journal-title":"J Lipid Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.metabol.2008.10.015","article-title":"The metabolism of plant sterols is disturbed in postmenopausal women with coronary artery disease","volume":"58","author":"H Gylling","year":"2009","journal-title":"Metabolism"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.numecd.2005.04.001","article-title":"Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the Prospective Cardiovascular Munster (PROCAM) study","volume":"16","author":"G Assmann","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0735-1097(00)00527-1","article-title":"Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women","volume":"35","author":"RA Rajaratnam","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/meta.2002.36298","article-title":"Serum plant sterols as a potential risk factor for coronary heart disease","volume":"51","author":"T Sudhop","year":"2002","journal-title":"Metabolism"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1194\/jlr.P000471","article-title":"Phytosterol plasma concentrations and coronary heart disease in the prospective Spanish EPIC cohort","volume":"51","author":"V Escurriol","year":"2010","journal-title":"J Lipid Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.atherosclerosis.2006.10.032","article-title":"Moderately elevated plant sterol levels are associated with reduced cardiovascular risk\u2014the LASA study","volume":"196","author":"K Fassbender","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1194\/jlr.M600371-JLR200","article-title":"Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study","volume":"48","author":"S Pinedo","year":"2007","journal-title":"J Lipid Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1161\/01.ATV.0000149140.00499.92","article-title":"No association between plasma levels of plant sterols and atherosclerosis in mice and men","volume":"24","author":"KR Wilund","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.atherosclerosis.2008.06.014","article-title":"Association of plasma phytosterol concentrations with incident coronary heart disease Data from the CORA study, a case-control study of coronary artery disease in women","volume":"203","author":"E Windler","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"E911","DOI":"10.1152\/ajpendo.00328.2001","article-title":"Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans","volume":"282","author":"RE Ostlund Jr","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1194\/jlr.M300368-JLR200","article-title":"Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men","volume":"45","author":"J Pihlajamaki","year":"2004","journal-title":"J Lipid Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/oxfordjournals.aje.a115479","article-title":"Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population","volume":"131","author":"TA Miettinen","year":"1990","journal-title":"Am J Epidemiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/08910600500519854","article-title":"Examination of intestinal conversion of cholesterol to coprostanol in 633 healthy subjects reveals an age- and sex-dependent pattern","volume":"17","author":"P Benno","year":"2005","journal-title":"Microb Ecol Health Dis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mam.2009.02.003","article-title":"Cholesterol oxidation products in the vascular remodeling due to atherosclerosis","volume":"30","author":"G Poli","year":"2009","journal-title":"Mol Aspects Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(98)00196-8","article-title":"Oxysterols and atherosclerosis","volume":"142","author":"AJ Brown","year":"1999","journal-title":"Atherosclerosis"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1194\/jlr.M027102","article-title":"The role of oxysterols in control of endothelial stiffness","volume":"53","author":"TP Shentu","year":"2012","journal-title":"J Lipid Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11745-010-3393-4","article-title":"Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence","volume":"45","author":"R Micha","year":"2010","journal-title":"Lipids"},{"key":"ref61","first-page":"1283","article-title":"Fatty acid composition of serum lipids in patients with type 2 diabetes","volume":"58","author":"M Korani","year":"2012","journal-title":"Clin Lab"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.metabol.2009.07.010","article-title":"Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia Project","volume":"59","author":"JC Lopez-Alvarenga","year":"2010","journal-title":"Metabolism"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0026-0495(65)90004-1","article-title":"Serum cholesterol response to changes in the diet: IV. Particular saturated fatty acids in the diet","volume":"14","author":"A Keys","year":"1965","journal-title":"Metabolism"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3945\/ajcn.110.004622","article-title":"The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?","volume":"93","author":"A Astrup","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/MCO.0b013e328359e6ac","article-title":"Diverse physiological effects of long-chain saturated fatty acids: implications for cardiovascular disease","volume":"16","author":"MR Flock","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1093\/ajcn\/77.5.1146","article-title":"Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials","volume":"77","author":"RP Mensink","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3945\/ajcn.2009.27661","article-title":"Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review","volume":"91","author":"JE Hunter","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1017\/S0954422408116997","article-title":"Dairy product consumption and the metabolic syndrome","volume":"21","author":"LE van Meijl","year":"2008","journal-title":"Nutr Res Rev"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1079\/BJN20041257","article-title":"A comparison of the effects of cheese and butter on serum lipids, haemostatic variables and homocysteine","volume":"92","author":"AS Biong","year":"2004","journal-title":"Br J Nutr"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/07315724.2004.10719358","article-title":"Does fat in milk, butter and cheese affect blood lipids and cholesterol differently?","volume":"23","author":"T Tholstrup","year":"2004","journal-title":"J Am Coll Nutr"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/sj.ejcn.1602211","article-title":"Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects","volume":"59","author":"PJ Nestel","year":"2005","journal-title":"Eur J Clin Nutr"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3168\/jds.2010-3571","article-title":"Survey of the fatty acid composition of retail milk in the United States including regional and seasonal variations","volume":"94","author":"AM O'Donnell-Megaro","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/oby.2003.82","article-title":"mRNA levels of the insulin-signaling molecule SORBS1 in the adipose depots of nondiabetic women","volume":"11","author":"WS Yang","year":"2003","journal-title":"Obes Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2337\/diabetes.45.6.755","article-title":"Associations of fasting blood glucose with cholesterol absorption and synthesis in nondiabetic middle-aged men","volume":"45","author":"TE Stranberg","year":"1996","journal-title":"Diabetes"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/ajcn\/72.1.82","article-title":"Introducing a new component of the metabolic syndrome: low cholesterol absorption","volume":"72","author":"P Simonen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri1003","article-title":"Semaphorins in interactions between T cells and antigen-presenting cells","volume":"3","author":"H Kikutani","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0955-0674(00)00260-X","article-title":"Semaphorin-mediated axonal guidance via Rho-related G proteins","volume":"13","author":"BP Liu","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(00)80063-X","article-title":"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates","volume":"99","author":"L Tamagnone","year":"1999","journal-title":"Cell"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/sj.embor.7400114","article-title":"To move or not to move? Semaphorin signalling in cell migration","volume":"5","author":"L Tamagnone","year":"2004","journal-title":"EMBO Rep"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1101\/gad.1167304","article-title":"Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2","volume":"18","author":"T Toyofuku","year":"2004","journal-title":"Genes Dev"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1073\/pnas.0803386105","article-title":"Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses","volume":"105","author":"BP O'Connor","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2009.10.005","article-title":"Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis","volume":"79","author":"A Sadanandam","year":"2010","journal-title":"Microvasc Res"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.ATV.0000100402.69997.C3","article-title":"Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization","volume":"24","author":"C Johnson","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.CIR.0000121728.14930.DE","article-title":"Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth","volume":"109","author":"A Luttun","year":"2004","journal-title":"Circulation"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00048.2003","article-title":"Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture","volume":"85","author":"AC Newby","year":"2005","journal-title":"Physiol Rev"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1128\/MCB.01748-06","article-title":"FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription","volume":"27","author":"H Li","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/geno.2000.6472","article-title":"Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse","volume":"72","author":"Y Liang","year":"2001","journal-title":"Genomics"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2156-13-12","article-title":"Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5","volume":"13","author":"DK Nolan","year":"2012","journal-title":"BMC Genet"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1474-4422(12)70234-X","article-title":"Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies","volume":"11","author":"M Traylor","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1161\/STROKEAHA.112.665760","article-title":"Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations","volume":"43","author":"S Bevan","year":"2012","journal-title":"Stroke"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/eurjhf\/hfs176","article-title":"Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study","volume":"15","author":"JG Smith","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1101\/gr.3694705","article-title":"Exploring relationships and mining data with the UCSC Gene Sorter","volume":"15","author":"WJ Kent","year":"2005","journal-title":"Genome Res"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00424-009-0768-6","article-title":"Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease","volume":"460","author":"R Kohler","year":"2010","journal-title":"Pflugers Arch"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1161\/01.RES.0000196557.93717.95","article-title":"Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk","volume":"97","author":"M Senti","year":"2005","journal-title":"Circ Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1172\/JCI30836","article-title":"The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans","volume":"118","author":"K Toyama","year":"2008","journal-title":"J Clin Invest"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"43123","DOI":"10.1074\/jbc.M111.262741","article-title":"GDP-mannose-4,6-dehydratase (GMDS) deficiency renders colon cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor- and CD95-mediated apoptosis by inhibiting complex II formation","volume":"286","author":"K Moriwaki","year":"2011","journal-title":"J Biol Chem"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1471-4159.2012.07796.x","article-title":"Subcellular localization and transcription regulatory potency of KCNIP\/Calsenilin\/DREAM\/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression","volume":"123","author":"P Pruunsild","year":"2012","journal-title":"J Neurochem"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuroscience.2010.11.051","article-title":"KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons","volume":"176","author":"ML Bourdeau","year":"2011","journal-title":"Neuroscience"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"11836","DOI":"10.1073\/pnas.182426699","article-title":"Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator","volume":"99","author":"S Surapureddi","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1517\/14728222.2012.715633","article-title":"PPARalpha as a therapeutic target in inflammation-associated diseases","volume":"16","author":"P Gervois","year":"2012","journal-title":"Expert Opin Ther Targets"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng.784","article-title":"Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease","volume":"43","author":"H Schunkert","year":"2011","journal-title":"Nat Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0099509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T01:21:09Z","timestamp":1689297669000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0099509"}},"subtitle":[],"editor":[{"given":"Daniel","family":"Monleon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":101,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0099509","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}