{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:29:08Z","timestamp":1790389748590,"version":"4.1.0"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0099766","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T20:07:24Z","timestamp":1402430844000},"page":"e99766","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Efficacy of a Crosslinked Hyaluronic Acid-Based Hydrogel as a Tear Film Supplement: A Masked Controlled Study"],"prefix":"10.1371","volume":"9","author":[{"given":"David L.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda K.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","article-title":"The epidemiology of dry eye disease: Report of the epidemiology subcommittee of the International Dry Eye Work Shop (2007)","volume":"5","author":"JA Smith","year":"2007","journal-title":"Ocul Surf"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cvsm.2007.12.002","article-title":"Immunopathogenesis of keratoconjunctivitis sicca in the dog","volume":"38","author":"DL Williams","year":"2008","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1001\/archopht.1989.01070020276038","article-title":"Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: treatment with cyclosporine eye drops","volume":"107","author":"RL Kaswan","year":"1989","journal-title":"Arch Ophthalmol"},{"key":"ref4","first-page":"1057","article-title":"The impact of topical cyclosporine A emulsion 0.05% on the outcomes of patients with keratoconjunctivitis sicca. Curr Med Res Opin","volume":"21","author":"K Stonecipher","year":"2005"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/112067219800800206","article-title":"Polyacrylic acid gel in patients with dry eyes: a randomised comparison with polyvinyl alcohol","volume":"8","author":"AJ Bron","year":"1998","journal-title":"Eur J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1016\/S0142-9612(02)00194-1","article-title":"Hyaluronic acid hydrogel in the treatment of osteoarthritis","volume":"23","author":"R Barbucci","year":"2002","journal-title":"Biomaterials"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.optm.2010.08.003","article-title":"A review of hyaluronan and its ophthalmic applications","volume":"82","author":"MJ Rah","year":"2011","journal-title":"Optometry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3233\/BIR-1994-31302","article-title":"Viscoelasticity of hyaluronic acid with different molecular weights","volume":"31","author":"Y Kobayashi","year":"1994","journal-title":"Biorheology"},{"key":"ref9","first-page":"62","article-title":"Sodium hyaluronate eyedrops enhance tear film stability","volume":"40","author":"T Hamano","year":"1996","journal-title":"Jpn J Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/jbm.a.32481","article-title":"Comparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ophthalmic applications","volume":"92A","author":"F Guillaumie","year":"2010","journal-title":"J Biomed Mater Res Part A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/bip.1968.360060603","article-title":"Rheology of hyaluronic acid","volume":"6","author":"DA Gibbs","year":"1968","journal-title":"Biopolymers"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/OPTH.S1439","article-title":"Use of viscoelastic substance in ophthalmic surgery \u2013 focus on sodium hyaluronate","volume":"2","author":"T Higashide","year":"2008","journal-title":"Clin Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/00003226-200405000-00015","article-title":"Development of a rabbit model of tear film instability and evaluation of viscosity of artificial tear preparations","volume":"23","author":"S Nakamura","year":"2004","journal-title":"Cornea"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Yang G, Prestwich GD, Mann BK (2011) Thiolated carboxymethyl hyaluronic acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci Article ID 851593: 1-7. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.hindawi.com\/isrn\/veterinary.science\/2011\/851593\/\" xlink:type=\"simple\">http:\/\/www.hindawi.com\/isrn\/veterinary.science\/2011\/851593\/<\/ext-link>. Accessed 20 February 2014.","DOI":"10.5402\/2011\/851593"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1463-5224.2010.00771.x","article-title":"A crosslinked hyaluronan gel accelerate healing of corneal epithelial abrasion and alkali burn injuries in rabbits","volume":"13","author":"G Yang","year":"2010","journal-title":"Vet Ophthalmol"},{"key":"ref16","unstructured":"Williams DL, Mann BK (2013) A crosslinked HA-based hydrogel ameliorates dry eye symptoms in dogs. Int J Biomater Article ID 460437. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.hindawi.com\/journals\/ijbm\/2013\/460437\/\" xlink:type=\"simple\">http:\/\/www.hindawi.com\/journals\/ijbm\/2013\/460437\/<\/ext-link>. Accessed 20 February 2014."},{"key":"ref17","first-page":"229","article-title":"Comparison of hyaluronic acid-containing topical eye drops with carbomer-based topical ocular gel as a tear replacement in canine keratoconjunctivitis sicca; a prospective study in twenty-five dogs","volume":"3","author":"DL Williams","year":"2012","journal-title":"Vet Res Forum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"MF Festing","year":"2002","journal-title":"ILAR J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/bjo.71.9.645","article-title":"Eyes or patients? Traps for the unwary in the statistical analysis of ophthalmological studies","volume":"71","author":"RG Newcombe","year":"1987","journal-title":"Br J Ophthalmol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0099766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T12:51:47Z","timestamp":1716814307000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0099766"}},"subtitle":[],"editor":[{"given":"Elisabeth","family":"Engel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0099766","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,10]]}}}