{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:50:15Z","timestamp":1791539415068,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0100129","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:02:25Z","timestamp":1403136145000},"page":"e100129","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Boswellic Acid-Containing Extract Ameliorates Schistosomiasis Liver Granuloma and Fibrosis through Regulating NF-\u03baB Signaling in Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Miao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"B\u00fcchele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maohong","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dake","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Simmet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1756-3305-4-234","article-title":"Neglected tropical diseases and the millennium development goals: why the \u201cother diseases\u201d matter: reality versus rhetoric","volume":"4","author":"DH Molyneux","year":"2011","journal-title":"Parasit Vectors"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"P Steinmann","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref3","first-page":"557","article-title":"Endemic status of schistosomiasis in People\u2019s Republic of China in 2012","volume":"25","author":"SZ Li","year":"2013","journal-title":"Zhongguo xue xi chong bing fang zhi za zhi"},{"key":"ref4","first-page":"307","article-title":"Influence factors of schistosoma japonum infection among fishermen in eastern dongting lake region. Zhongguo xue xi chong bing fang zhi za zhi","volume":"31","author":"XL Yu","year":"2013"},{"key":"ref5","first-page":"314","article-title":"Image analysis of ultrasonography on the liver and spleen of chronic schistosomiasis patients: a report of 447 cases Zhongguo xue xi chong bing fang zhi za zhi","volume":"28","author":"XH Wang","year":"2008"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.actatropica.2008.04.003","article-title":"Schistosomiasis and hepatic fibrosis regression","volume":"108","author":"ZA Andrade","year":"2008","journal-title":"Acta Trop"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1086\/314999","article-title":"Susceptibility to periportal (Symmers) fibrosis in human Schistosoma mansoni infections: evidence that intensity and duration of infection, gender, and inherited factors are critical in disease progression","volume":"180","author":"Q Mohamed-Ali","year":"1999","journal-title":"J Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-\u03baB signaling","volume":"132","author":"MS Hayden","year":"2008","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.21459","article-title":"Hepatic fibrosis 2006: report of the Third AASLD Single Topic Conference","volume":"45","author":"SL Friedman","year":"2007","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrgastro.2010.213","article-title":"NF-\u03baB in the liver\u2013linking injury, fibrosis and hepatocellular carcinoma","volume":"8","author":"T Luedde","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actatropica.2008.05.027","article-title":"Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection","volume":"108","author":"IR Caldas","year":"2008","journal-title":"Acta Trop"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.4049\/jimmunol.181.10.7214","article-title":"IL-10 and TGF-\u03b2redundantly protect against severe liver injury and mortality during acute schistosomiasis","volume":"181","author":"DR Herbert","year":"2008","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actatropica.2008.04.016","article-title":"The role of chemokines in controlling granulomatous inflammation in Schistosoma mansoni infection","volume":"108","author":"PR Souza","year":"2008","journal-title":"Acta Trop"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.exppara.2011.09.014","article-title":"Evidence of intra-hepatic vascular proliferation remodeling early after cure in experimental schistosomiasis mansoni: an immunohistochemical descriptive study","volume":"130","author":"NS Abdel fattah","year":"2012","journal-title":"Exp Parasitol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.exppara.2011.01.016","article-title":"Evaluation of the role of angiogenic factors in the pathogenesis of schistosomiasis","volume":"128","author":"F Shariati","year":"2011","journal-title":"Exp Parasitol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2165\/11586800-000000000-00000","article-title":"Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data","volume":"50","author":"M Abdel-tawab","year":"2011","journal-title":"Clin Pharmacokinet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.phymed.2010.03.003","article-title":"Modulation of the immune system by Boswellia serrata extracts and boswellic acids","volume":"17","author":"HP Ammon","year":"2010","journal-title":"Phytomedicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2362.2008.01955.x","article-title":"Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid","volume":"38","author":"G Latella","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1749-8546-6-36","article-title":"Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats","volume":"6","author":"EN Ali","year":"2011","journal-title":"Chin Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00436-012-3237-7","article-title":"A boswellic acid-containing extract attenuates hepatic granuloma in C57BL\/6 mice infected with Schistosoma japonicum","volume":"112","author":"M Liu","year":"2013","journal-title":"Parasitol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/hep.22725","article-title":"NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis","volume":"49","author":"X Hou","year":"2009","journal-title":"Hepatology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0026-895X(25)08764-4","article-title":"Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-\u03b2-boswellic acid","volume":"47","author":"H Safayhi","year":"1995","journal-title":"Mol Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1476-5381.1996.tb15235.x","article-title":"Acetyl-11-keto-\u03b2-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity","volume":"117","author":"ER Sailer","year":"1996","journal-title":"Br J Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1476-5381.2010.01020.x","article-title":"Inhibition of microsomal prostaglandin E<sub>2<\/sub> synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense","volume":"162","author":"U Siemoneit","year":"2011","journal-title":"Br J Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"G798","DOI":"10.1152\/ajpgi.00433.2004","article-title":"Effects of Boswellia serrata in mouse models of chemically induced colitis","volume":"288","author":"PR Kiela","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1074\/jbc.M409477200","article-title":"Inhibition of I\u03baB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo","volume":"280","author":"T Syrovets","year":"2005","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/ATVBAHA.107.155606","article-title":"Antiinflammatory and antiatherogenic effects of the NF-\u03baB inhibitor acetyl-11-keto-\u03b2-boswellic acid in LPS-challenged ApoE\u2212\/\u2212 mice","volume":"28","author":"C Cuaz-p\u00e9rolin","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.4049\/jimmunol.174.1.498","article-title":"Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-\u03b1 induction in monocytes by direct interaction with I\u03baB kinases","volume":"174","author":"T Syrovets","year":"2005","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bmcl.2011.10.112","article-title":"Acyl derivatives of boswellic acids as inhibitors of NF-\u03baB and STATs","volume":"22","author":"A Kumar","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"R Bataller","year":"2012","journal-title":"J Clin Invest"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"SL Friedman","year":"2004","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gut.50.6.891","article-title":"Transcriptional regulation of hepatic stellate cell activation","volume":"50","author":"DA Mann","year":"2002","journal-title":"Gut"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/hep.21036","article-title":"Proteasome inhibition induces hepatic stellate cell apoptosis","volume":"43","author":"A Anan","year":"2006","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"SL Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.ijpara.2006.04.015","article-title":"A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis","volume":"36","author":"PB Bartley","year":"2006","journal-title":"Int J Parasitol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s001099900019","article-title":"Molecular and biological properties of vascular endothelial growth factor","volume":"77","author":"N Ferrara","year":"1999","journal-title":"J Mol Med"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Giatromanolaki A, Kotsiou S, Koukourakis MI, Sivridis E (2007) Angiogenic factor expression in hepatic cirrhosis. Mediators Inflamm: 67187.","DOI":"10.1155\/2007\/67187"},{"key":"ref38","first-page":"907","article-title":"Vascular endothelial growth factor level in chronic liver diseases","volume":"32","author":"MM Makhlouf","year":"2002","journal-title":"J Egypt Soc Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.4049\/jimmunol.162.7.4122","article-title":"Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection","volume":"162","author":"PG Fallon","year":"1999","journal-title":"J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.actatropica.2008.04.006","article-title":"Eosinophil activation status, cytokines and liver fibrosis in Schistosoma mansoni infected patients","volume":"108","author":"D Silveira-lemos","year":"2008","journal-title":"Acta Trop"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e26943","DOI":"10.1371\/journal.pone.0026943","article-title":"Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets","volume":"6","author":"B Park","year":"2011","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.phymed.2011.06.035","article-title":"Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE)","volume":"18","author":"AM Shehata","year":"2011","journal-title":"Phytomedicine"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mvr.2011.08.002","article-title":"Boswellic acid inhibits inflammatory angiogenesis in a murine sponge model","volume":"82","author":"S Saraswati","year":"2011","journal-title":"Microvasc Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.4049\/jimmunol.0900521","article-title":"Targeting NF-\u03baB with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis","volume":"183","author":"H Wang","year":"2006","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/hep.22934","article-title":"The etiology of liver damage imparts cytokines transforming growth factor \u03b21 or interleukin-13 as driving forces in fibrogenesis","volume":"50","author":"HL Weng","year":"2009","journal-title":"Hepatology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0100129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:24:31Z","timestamp":1746271471000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0100129"}},"subtitle":[],"editor":[{"given":"Laurent","family":"R\u00e9nia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,18]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0100129","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,18]]}}}