{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:35Z","timestamp":1791156515852,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0100217","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T20:51:33Z","timestamp":1403211093000},"page":"e100217","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":118,"title":["Spontaneous Colitis in Muc2-Deficient Mice Reflects Clinical and Cellular Features of Active Ulcerative Colitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Ulf A.","family":"Wenzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rydstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Jonstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hengst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin EV.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Velcich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"\u00d6hman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Strid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Sj\u00f6vall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar C.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"ref1","first-page":"15064","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA","volume":"105","author":"MEV Johansson","year":"2008"},{"key":"ref2","first-page":"4659","article-title":"Colloquium Paper: The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA","volume":"108","author":"MEV Johansson","year":"2011"},{"key":"ref3","first-page":"255","article-title":"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science","volume":"334","author":"S Vaishnava","year":"2011"},{"key":"ref4","first-page":"188","article-title":"The goblet cell: a key player in ischaemia-reperfusion injury. Gut","volume":"62","author":"MEV Johansson","year":"2013"},{"key":"ref5","first-page":"2066","article-title":"Inflammatory bowel disease. N Engl J Med","volume":"361","author":"C Abraham","year":"2009"},{"key":"ref6","first-page":"1606","article-title":"Ulcerative colitis. Lancet","volume":"380","author":"I Ord\u00e1s","year":"2012"},{"key":"ref7","first-page":"307","article-title":"Genetics and pathogenesis of inflammatory bowel disease. Nature","volume":"474","author":"B Khor","year":"2011"},{"key":"ref8","first-page":"281","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut","volume":"63","author":"MEV Johansson","year":"2014"},{"key":"ref9","first-page":"1330","article-title":"Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet","volume":"41","author":"Consortium UK IBD Genetics","year":"2009"},{"key":"ref10","first-page":"1726","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2. Science","volume":"295","author":"A Velcich","year":"2002"},{"key":"ref11","first-page":"357","article-title":"IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology","volume":"144","author":"SZ Hasnain","year":"2013"},{"key":"ref12","first-page":"91","article-title":"T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol","volume":"150","author":"L Dianda","year":"1997"},{"key":"ref13","first-page":"307","article-title":"Oxazolone-induced colitis in BALB\/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. J Pharmacol Sci","volume":"96","author":"R Kojima","year":"2004"},{"key":"ref14","first-page":"G667","article-title":"Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice. Am J Physiol Gastrointest Liver Physiol","volume":"301","author":"N Burger-van Paassen","year":"2011"},{"key":"ref15","first-page":"e6020","article-title":"<italic>Chlamydia pneumoniae<\/italic> hides inside apoptotic neutrophils to silently infect and propagate in macrophages. PLoS ONE","volume":"4","author":"J Rupp","year":"2009"},{"key":"ref16","unstructured":"Pfaffl MW (2006) Relative quantification. In: Dorak, MT, editor. Real-time PCR. New York: Taylor and Francis. 63\u201382."},{"key":"ref17","first-page":"1388","article-title":"Bacterial colonization leads to the colonic secretion of RELM\u03b2\/FIZZ2, a novel goblet cell-specific protein","volume":"125","author":"W HE","year":"2003","journal-title":"YGAST"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.4049\/jimmunol.178.9.5789","article-title":"Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral <italic>Salmonella<\/italic> infection","volume":"178","author":"A Rydstr\u00f6m","year":"2007","journal-title":"J Immunol"},{"key":"ref19","first-page":"1141","article-title":"The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn\u2019s disease and ulcerative colitis patients. J Med Microbiol","volume":"55","author":"R Bibiloni","year":"2006"},{"key":"ref20","first-page":"733","article-title":"Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell\/APC ratio, source of mouse strain, and regional localization. J Immunol","volume":"187","author":"TL Denning","year":"2011"},{"key":"ref21","first-page":"323","article-title":"Dendritic cell and macrophage heterogeneity in vitro &amp; in vivo. Immunity","volume":"35","author":"D Hashimoto","year":"2011"},{"key":"ref22","first-page":"498","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6C<sup>hi<\/sup> monocyte precursors. Mucosal Immunol","volume":"6","author":"CC Bain","year":"2012"},{"key":"ref23","first-page":"139","article-title":"Inflammation switches the differentiation program of Ly6C<sup>hi<\/sup> monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med","volume":"209","author":"A Rivollier","year":"2012"},{"key":"ref24","first-page":"427","article-title":"Unravelling the pathogenesis of inflammatory bowel disease. Nature","volume":"448","author":"RJ Xavier","year":"2007"},{"key":"ref25","first-page":"1190","article-title":"Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse. Inflamm Bowel Dis","volume":"15","author":"JP Gisbert","year":"2009"},{"key":"ref26","first-page":"104","article-title":"Intestinal CD103<sup>\u2212<\/sup> dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunol","volume":"6","author":"V Cerovic","year":"2012"},{"key":"ref27","first-page":"354","article-title":"An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity. Mucosal Immunol","volume":"4","author":"RD Eri","year":"2010"},{"key":"ref28","first-page":"773","article-title":"CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. Eur J Immunol","volume":"41","author":"B Weber","year":"2011"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI45538","article-title":"Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice","volume":"121","author":"J Fu","year":"2011","journal-title":"J Clin Invest"},{"key":"ref30","first-page":"557","article-title":"E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity","volume":"32","author":"KRR Siddiqui","year":"2010"},{"key":"ref31","first-page":"6843","article-title":"An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. The J. Immunol","volume":"184","author":"AM Platt","year":"2010"},{"key":"ref32","first-page":"502","article-title":"Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity","volume":"31","author":"C Varol","year":"2009"},{"key":"ref33","first-page":"1995","article-title":"A role for CD47 in the development of experimental colitis mediated by SIRPalpha<sup>+<\/sup>CD103<sup>\u2212<\/sup> dendritic cells. J Exp Med","volume":"206","author":"G Fortin","year":"2009"},{"key":"ref34","first-page":"21","article-title":"Loss of CD103<sup>+<\/sup> intestinal dendritic cells during colonic inflammation. World J Gastroenterol","volume":"16","author":"UG Strauch","year":"2010"},{"key":"ref35","first-page":"3150","article-title":"CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur J Immunol","volume":"42","author":"S Tamoutounour","year":"2012"},{"key":"ref36","first-page":"2269","article-title":"Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23\/IFN-gamma axis. J Clin Invest","volume":"118","author":"N Kamada","year":"2008"},{"key":"ref37","first-page":"e69839","article-title":"Lesional accumulation of CD163-expressing cells in the gut of patients with inflammatory bowel disease. PLoS ONE","volume":"8","author":"E Franz\u00e8","year":"2013"},{"key":"ref38","first-page":"595","article-title":"Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory\/T effector cell balance and oral tolerance induction. Gut","volume":"59","author":"G Matteoli","year":"2010"},{"key":"ref39","first-page":"1481","article-title":"Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut","volume":"58","author":"ID Iliev","year":"2009"},{"key":"ref40","first-page":"2139","article-title":"Small intestinal CD103<sup>+<\/sup> dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med","volume":"205","author":"E Jaensson","year":"2008"},{"key":"ref41","first-page":"186","article-title":"Density of CD163<sup>+<\/sup>CD11c<sup>+<\/sup> Dendritic Cells Increases and CD103<sup>+<\/sup> Dendritic cells decreases in the coeliac lesion. Scand J Immunol","volume":"74","author":"ACR Beitnes","year":"2011"},{"key":"ref42","first-page":"415","article-title":"Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol","volume":"10","author":"C Varol","year":"2010"},{"key":"ref43","first-page":"412","article-title":"Intestinal CD103<sup>+<\/sup> dendritic cells: master regulators of tolerance? Trends Immunol","volume":"32","author":"CL Scott","year":"2011"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0100217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:16:10Z","timestamp":1540232170000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0100217"}},"subtitle":[],"editor":[{"given":"Markus M.","family":"Heimesaat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0100217","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}