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http:\/\/wwwalzcouk\/research\/statistics<\/ext-link>."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e66252","DOI":"10.1371\/journal.pone.0066252","article-title":"Prevalence studies of dementia in mainland china, Hong Kong and Taiwan: a systematic review and meta-analysis","volume":"8","author":"YT Wu","year":"2013","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/S0140-6736(13)60221-4","article-title":"Epidemiology of Alzheimer\u2019s disease and other forms of dementia in China, 1990\u20132010: a systematic review and analysis","volume":"381","author":"KY Chan","year":"2013","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"LE 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