{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:14:27Z","timestamp":1779236067293,"version":"3.51.4"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0100545","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T20:25:04Z","timestamp":1403727904000},"page":"e100545","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Analysis of Cross-Reactive Neutralizing Antibodies in Human HFMD Serum with an EV71 Pseudovirus-Based Assay"],"prefix":"10.1371","volume":"9","author":[{"given":"Huafei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiheng","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenglun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/1040841X.2011.580723","article-title":"The virology and developments toward control of human enterovirus 71","volume":"37","author":"L Yi","year":"2011","journal-title":"Crit Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.vaccine.2012.10.032","article-title":"Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: current genotyping of EV71 does not reflect their antigenicity","volume":"31","author":"Y Chen","year":"2013","journal-title":"Vaccine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1743-422X-7-300","article-title":"Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large-scale outbreaks from 2008","volume":"7","author":"Z Zhu","year":"2010","journal-title":"Virol J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"LE Schmidt NJ","year":"1974","journal-title":"J Infect Dis"},{"key":"ref5","first-page":"731","article-title":"2 cases of meningeal syndrome, probably caused by enterovirus 71 (EV71)","volume":"40","author":"DL Hancil J","year":"1985","journal-title":"Cesk Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF01317504","article-title":"Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria","volume":"60","author":"M Chumakov","year":"1979","journal-title":"Arch Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.7883\/yoken1952.33.167","article-title":"Epidemic of hand, foot and mouth disease in Gifu Prefecture in 1978","volume":"33","author":"OM Miwa C","year":"1980","journal-title":"Jpn J Med Sci Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1574-6976.2002.tb00601.x","article-title":"An overview of the evolution of enterovirus 71 and its clinical and public health significance","volume":"26","author":"PC McMinn","year":"2002","journal-title":"FEMS Microbiol Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"LP Solomon T","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1743-422X-7-277","article-title":"Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008","volume":"7","author":"YP Huang","year":"2010","journal-title":"Virol J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998","volume":"73","author":"BA Brown","year":"1999","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"P McMinn","year":"2001","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00705-005-0684-9","article-title":"Molecular epidemiology of enterovirus 71 over two decades in an Australian urban community","volume":"151","author":"SA Sanders","year":"2006","journal-title":"Arch Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3201\/eid0904.020395","article-title":"Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes","volume":"9","author":"MJ Cardosa","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7883\/yoken.JJID.2009.254","article-title":"Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007","volume":"62","author":"M Iwai","year":"2009","journal-title":"Jpn J Infect Dis"},{"key":"ref16","first-page":"437","article-title":"[Epidemiology and etiology of hand-foot-and-mouth disease in Shanghai, 2009]","volume":"26","author":"Z Teng","year":"2010","journal-title":"Bing Du Xue Bao"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3201\/eid1311.070632","article-title":"Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005","volume":"13","author":"PV Tu","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.virusres.2008.07.015","article-title":"The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007","volume":"137","author":"YP Huang","year":"2008","journal-title":"Virus Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e25662","DOI":"10.1371\/journal.pone.0025662","article-title":"The persistent circulation of enterovirus 71 in People&apos;s Republic of China: causing emerging nationwide epidemics since 2008","volume":"6","author":"X Tan","year":"2011","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"F-C Zhu","year":"2013","journal-title":"The Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e79599","DOI":"10.1371\/journal.pone.0079599","article-title":"The cross-neutralizing activity of enterovirus 71 subgenotype c4 vaccines in healthy chinese infants and children","volume":"8","author":"Q Mao","year":"2013","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1128\/JVI.02856-06","article-title":"An attenuated strain of enterovirus 71 belonging to genotype a showed a broad spectrum of antigenicity with attenuated neurovirulence in cynomolgus monkeys","volume":"81","author":"M Arita","year":"2007","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1016\/j.vaccine.2009.03.060","article-title":"Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007","volume":"27","author":"K Mizuta","year":"2009","journal-title":"Vaccine"},{"key":"ref24","first-page":"91","article-title":"Safe and Objective Assay of Enterovirus 71 Neutralizing","volume":"28","author":"Jin Jun","year":"2012","journal-title":"CHEM RES CHINESE UNIVERSITIES"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/1743-422X-10-250","article-title":"Establishment of cell lines with increased susceptibility to EV71\/CA16 by stable overexpression of SCARB2","volume":"10","author":"X Li","year":"2013","journal-title":"Virol J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e56341","DOI":"10.1371\/journal.pone.0056341","article-title":"Complete genome analysis of the C4 subgenotype strains of enterovirus 71: predominant recombination C4 viruses persistently circulating in China for 14 years","volume":"8","author":"Y Zhang","year":"2013","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1743-422X-7-94","article-title":"An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China","volume":"7","author":"Y Zhang","year":"2010","journal-title":"Virol J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e64116","DOI":"10.1371\/journal.pone.0064116","article-title":"Development and evaluation of a pseudovirus-luciferase assay for rapid and quantitative detection of neutralizing antibodies against enterovirus 71","volume":"8","author":"X Wu","year":"2013","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/nbt0898-702b","article-title":"RLU and studies using the luciferase reporter gene","volume":"16","author":"JM Vicat","year":"1998","journal-title":"Nat Biotechnol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jviromet.2012.07.011","article-title":"Optimization and proficiency testing of a pseudovirus-based assay for detection of HIV-1 neutralizing antibody in China","volume":"185","author":"J Nie","year":"2012","journal-title":"J Virol Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e27895","DOI":"10.1371\/journal.pone.0027895","article-title":"Emergence and transmission pathways of rapidly evolving evolutionary branch C4a strains of human enterovirus 71 in the Central Plain of China","volume":"6","author":"Y Zhang","year":"2011","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jviromet.2012.11.014","article-title":"Development of a Coxsackievirus A16 neutralization assay based on pseudoviruses for measurement of neutralizing antibody titer in human serum","volume":"187","author":"J Jin","year":"2013","journal-title":"J Virol Methods"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/088922200308792","article-title":"Diversity of envelope glycoprotein from human immunodeficiency virus type 1 of recent seroconverters in Thailand","volume":"16","author":"FE McCutchan","year":"2000","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/bmb\/58.1.19","article-title":"Evolutionary and immunological implications of contemporary HIV-1 variation","volume":"58","author":"B Korber","year":"2001","journal-title":"Br Med Bull"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ni0304-233","article-title":"HIV vaccine design and the neutralizing antibody problem","volume":"5","author":"DR Burton","year":"2004","journal-title":"Nat Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vaccine.2012.10.084","article-title":"Seasonal influenza vaccine efficacy and its determinants in children and non-elderly adults: a systematic review with meta-analyses of controlled trials","volume":"31","author":"CA DiazGranados","year":"2012","journal-title":"Vaccine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e79783","DOI":"10.1371\/journal.pone.0079783","article-title":"Formalin-Inactivated EV71 Vaccine Candidate Induced Cross-Neutralizing Antibody against Subgenotypes B1, B4, B5 and C4A in Adult Volunteers","volume":"8","author":"AH Chou","year":"2013","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e2067","DOI":"10.1371\/journal.pntd.0002067","article-title":"Cross-reactive neutralizing antibody responses to enterovirus 71 infections in young children: implications for vaccine development","volume":"7","author":"ML Huang","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-010-0472-9","article-title":"Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008","volume":"41","author":"H Yu","year":"2010","journal-title":"Virus Genes"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e32405","DOI":"10.1371\/journal.pone.0032405","article-title":"Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China","volume":"7","author":"X Wang","year":"2012","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jviromet.2013.07.051","article-title":"Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013","volume":"193","author":"JS Wu","year":"2013","journal-title":"J Virol Methods"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1016\/j.vaccine.2012.03.010","article-title":"Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: a randomized, placebo-controlled, double-blind, Phase I clinical trial","volume":"30","author":"YP Li","year":"2012","journal-title":"Vaccine"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1128\/CVI.00491-13","article-title":"Immunogenicity, safety, and lot consistency of a novel inactivated enterovirus 71 vaccine in Chinese children aged 6 to 59 months","volume":"20","author":"YM Hu","year":"2013","journal-title":"Clin Vaccine Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00705-011-1136-3","article-title":"Antigenicity, animal protective effect and genetic characteristics of candidate vaccine strains of enterovirus 71","volume":"157","author":"Q Mao","year":"2012","journal-title":"Arch Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JCM.43.8.3835-3839.2005","article-title":"Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People&apos;s Republic of China","volume":"43","author":"L Li","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/JCM.02338-09","article-title":"Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China","volume":"48","author":"Y Zhang","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"11967","DOI":"10.1128\/JVI.00902-12","article-title":"A neonatal mouse model of coxsackievirus A16 for vaccine evaluation","volume":"86","author":"Q Mao","year":"2012","journal-title":"J Virol"},{"key":"ref49","first-page":"1537","article-title":"Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China","volume":"17","author":"K Zhao","year":"2011","journal-title":"Emerg Infect Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0100545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T15:46:00Z","timestamp":1689349560000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0100545"}},"subtitle":[],"editor":[{"given":"Xiao-Fang","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0100545","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]}}}