{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:24:45Z","timestamp":1792189485215,"version":"4.4.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0100682","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T20:35:15Z","timestamp":1403296515000},"page":"e100682","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Toxin Diversity Revealed by a Transcriptomic Study of Ornithoctonus huwena"],"prefix":"10.1371","volume":"9","author":[{"given":"Yiya","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanze","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongzhi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1134\/S0006297909130069","article-title":"Molecular diversity of spider venom","volume":"74","author":"AA Vassilevski","year":"2009","journal-title":"Biochemistry (Mosc)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(10)62230-1","article-title":"Spider bite","volume":"378","author":"GK Isbister","year":"2011","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13315","DOI":"10.1074\/jbc.R109.076596","article-title":"Use of venom peptides to probe ion channel structure and function","volume":"285","author":"S Dutertre","year":"2010","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/nsmb.1679","article-title":"Interactions between lipids and voltage sensor paddles detected with tarantula toxins","volume":"16","author":"M Milescu","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.toxicon.2006.09.024","article-title":"Tarantula toxins interacting with voltage sensors in potassium channels","volume":"49","author":"KJ Swartz","year":"2007","journal-title":"Toxicon"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.200709869","article-title":"Tarantula toxins interact with voltage sensors within lipid membranes","volume":"130","author":"M Milescu","year":"2007","journal-title":"J Gen Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature03873","article-title":"Voltage-sensor activation with a tarantula toxin as cargo","volume":"436","author":"LR Phillips","year":"2005","journal-title":"nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature02632","article-title":"A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom","volume":"430","author":"SY Lee","year":"2004","journal-title":"nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0041-0101(01)00199-4","article-title":"Pharmacology and biochemistry of spider venoms","volume":"40","author":"LD Rash","year":"2002","journal-title":"Toxicon"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00726-010-0516-4","article-title":"Venomics: a new paradigm for natural products-based drug discovery","volume":"40","author":"I Vetter","year":"2011","journal-title":"Amino Acids"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1586\/14789450.5.5.731","article-title":"Proteome and peptidome profiling of spider venoms","volume":"5","author":"S Liang","year":"2008","journal-title":"Expert Rev Proteomics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.toxicon.2012.04.337","article-title":"Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads","volume":"60","author":"JK Klint","year":"2012","journal-title":"Toxicon"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbd.2010.01.001","article-title":"Venomics of the spider Ornithoctonus huwena based on transcriptomic versus proteomic analysis","volume":"5","author":"L Jiang","year":"2010","journal-title":"Comp Biochem Physiol Part D Genomics Proteomics"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, et al. (2013) Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Mol Cell Proteomics.","DOI":"10.1074\/mcp.M113.030353"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.toxicon.2008.03.024","article-title":"Molecular diversification based on analysis of expressed sequence tags from the venom glands of the Chinese bird spider Ornithoctonus huwena","volume":"51","author":"L Jiang","year":"2008","journal-title":"Toxicon"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1007011904904","article-title":"Indentification of venom proteins of spider S. huwena on two-dimensional electrophoresis gel by N-terminal microsequencing and mass spectrometric peptide mapping","volume":"19","author":"S Liang","year":"2000","journal-title":"J Protein Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1021\/pr0700192","article-title":"Proteomic and peptidomic characterization of the venom from the Chinese bird spider, Ornithoctonus huwena Wang","volume":"6","author":"C Yuan","year":"2007","journal-title":"J Proteome Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2164-12-259","article-title":"Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing","volume":"12","author":"J Durban","year":"2011","journal-title":"BMC Genomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.margen.2011.09.002","article-title":"Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome","volume":"5","author":"AO Lluisma","year":"2012","journal-title":"Mar Genomics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2011.10.001","article-title":"High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors","volume":"59","author":"Y Terrat","year":"2012","journal-title":"Toxicon"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jgg.2011.02.003","article-title":"The impact of next-generation sequencing on genomics","volume":"38","author":"J Zhang","year":"2011","journal-title":"J Genet Genomics"},{"key":"ref22","first-page":"251364","article-title":"Comparison of next-generation sequencing systems","volume":"2012","author":"L Liu","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"A Conesa","year":"2005","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/bib\/bbn017","article-title":"MEGA: a biologist-centric software for evolutionary analysis of DNA and protein sequences","volume":"9","author":"S Kumar","year":"2008","journal-title":"Brief Bioinform"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/bib\/5.2.150","article-title":"MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment","volume":"5","author":"S Kumar","year":"2004","journal-title":"Brief Bioinform"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1471-2164-9-279","article-title":"Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags","volume":"9","author":"F Fernandes-Pedrosa Mde","year":"2008","journal-title":"BMC Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.toxicon.2008.08.003","article-title":"Transcriptome analysis revealed novel possible venom components and cellular processes of the tarantula Chilobrachys jingzhao venom gland","volume":"52","author":"J Chen","year":"2008","journal-title":"Toxicon"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.cbpa.2007.01.027","article-title":"Cost of venom regeneration in Parabuthus transvaalicus (Arachnida: Buthidae)","volume":"147","author":"Z Nisani","year":"2007","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1242\/jeb.01713","article-title":"Intraspecific variation of venom injected by fish-hunting Conus snails","volume":"208","author":"JA Jakubowski","year":"2005","journal-title":"J Exp Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.peptides.2009.03.019","article-title":"Remarkable inter- and intra-species complexity of conotoxins revealed by LC\/MS","volume":"30","author":"J Davis","year":"2009","journal-title":"Peptides"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.toxicon.2010.02.025","article-title":"Dramatic intraspecimen variations within the injected venom of Conus consors: an unsuspected contribution to venom diversity","volume":"55","author":"S Dutertre","year":"2010","journal-title":"Toxicon"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1554","DOI":"10.1371\/journal.pntd.0001554","article-title":"A transcriptomic view of the proteome variability of newborn and adult Bothrops jararaca snake venoms","volume":"6","author":"A Zelanis","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0041-0101(96)00072-4","article-title":"Blockade of neuromuscular transmission by huwentoxin-I, purified from the venom of the Chinese bird spider Selenocosmia huwena","volume":"35","author":"PA Zhou","year":"1997","journal-title":"Toxicon"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0041-0101(00)00150-1","article-title":"The effect of Huwentoxin-I on Ca(2+) channels in differentiated NG108\u201315 cells, a patch-clamp study","volume":"39","author":"K Peng","year":"2001","journal-title":"Toxicon"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1074\/jbc.M513542200","article-title":"Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena","volume":"281","author":"Z Liu","year":"2006","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1745-7270.2006.00191.x","article-title":"Nuclear magnetic resonance studies on huwentoxin-XI from the Chinese bird spider Ornithoctonus huwena: 15N labeling and sequence-specific 1H, 15N nuclear magnetic resonance assignments","volume":"38","author":"K Peng","year":"2006","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e3414","DOI":"10.1371\/journal.pone.0003414","article-title":"Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas","volume":"3","author":"CH Yuan","year":"2008","journal-title":"PLoS ONE"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.jmb.2008.07.063","article-title":"Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor","volume":"382","author":"E Zakharova","year":"2008","journal-title":"J Mol Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1021\/pr1000016","article-title":"Molecular diversification of peptide toxins from the tarantula Haplopelma hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic, and genomic analyses","volume":"9","author":"X Tang","year":"2010","journal-title":"J Proteome Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1007\/s00018-010-0359-x","article-title":"Venom components from Citharischius crawshayi spider (Family Theraphosidae): exploring transcriptome, venomics, and function","volume":"67","author":"E Diego-Garcia","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/pmic.200600785","article-title":"Proteomic and peptidomic analysis of the venom from Chinese tarantula Chilobrachys jingzhao","volume":"7","author":"Z Liao","year":"2007","journal-title":"Proteomics"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Duan Z, Cao R, Jiang L, Liang S (2012) A combined de novo protein sequencing and cDNA library approach to the venomic analysis of Chinese spider Araneus ventricosus. J Proteomics.","DOI":"10.1016\/j.jprot.2012.10.011"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.zool.2009.04.001","article-title":"Transcriptome analysis of the venom glands of the Chinese wolf spider Lycosa singoriensis","volume":"113","author":"Y Zhang","year":"2010","journal-title":"Zoology (Jena)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/prot.20390","article-title":"A novel strategy for the identification of toxinlike structures in spider venom","volume":"59","author":"S Kozlov","year":"2005","journal-title":"Proteins"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2199-8-32","article-title":"Selection strategy and the design of hybrid oligonucleotide primers for RACE-PCR: cloning a family of toxin-like sequences from Agelena orientalis","volume":"8","author":"Z Pan","year":"2007","journal-title":"BMC Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Violette A, Biass D, Dutertre S, Koua D, Piquemal D, et al. (2012) Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach. J Proteomics.","DOI":"10.1016\/j.jprot.2012.06.001"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1186\/1471-2164-14-708","article-title":"Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies","volume":"14","author":"V Lavergne","year":"2013","journal-title":"BMC Genomics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-14-531","article-title":"The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms","volume":"14","author":"MJ Margres","year":"2013","journal-title":"BMC Genomics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.toxicon.2004.02.005","article-title":"An overview of peptide toxins from the venom of the Chinese bird spider Selenocosmia huwena Wang [ = Ornithoctonus huwena (Wang)]","volume":"43","author":"S Liang","year":"2004","journal-title":"Toxicon"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"47564","DOI":"10.1074\/jbc.M204063200","article-title":"Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena","volume":"277","author":"K Peng","year":"2002","journal-title":"J Biol Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF01024931","article-title":"Assignment of the three disulfide bridges of huwentoxin-I, a neurotoxin from the spider selenocosmia huwena","volume":"12","author":"D Zhang","year":"1993","journal-title":"J Protein Chem"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1023\/A:1020663619657","article-title":"Three-dimensional structure of Selenocosmia huwena lectin-I (SHL-I) from the venom of the spider Selenocosmia huwena by 2D-NMR","volume":"18","author":"S Lu","year":"1999","journal-title":"J Protein Chem"},{"key":"ref54","first-page":"976","article-title":"Purification and characterization of a neurotoxic peptide huwentoxin-III and a natural inactive mutant from the venom of the spider Selenocosmia huwena Wang (Ornithoctonus huwena Wang)","volume":"35","author":"RH Huang","year":"2003","journal-title":"Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.peptides.2011.10.029","article-title":"The effects of huwentoxin-I on the voltage-gated sodium channels of rat hippocampal and cockroach dorsal unpaired median neurons","volume":"34","author":"M Wang","year":"2012","journal-title":"Peptides"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"27301","DOI":"10.1074\/jbc.M111.246876","article-title":"Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV","volume":"286","author":"Y Xiao","year":"2011","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1631\/jzus.B0900393","article-title":"Mechanism of action of two insect toxins huwentoxin-III and hainantoxin-VI on voltage-gated sodium channels","volume":"11","author":"RL Wang","year":"2010","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2007.12.014","article-title":"Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom","volume":"582","author":"M Deng","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.cell.2010.03.052","article-title":"A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain","volume":"141","author":"CJ Bohlen","year":"2010","journal-title":"cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj2570509","article-title":"Purification and N-terminal partial sequence of anti-epilepsy peptide from venom of the scorpion Buthus martensii Karsch","volume":"257","author":"XH Zhou","year":"1989","journal-title":"Biochem J"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1523\/JNEUROSCI.22-06-02023.2002","article-title":"Kurtoxin, a gating modifier of neuronal high- and low-threshold ca channels","volume":"22","author":"SS Sidach","year":"2002","journal-title":"J Neurosci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jsb.2005.12.005","article-title":"Crystal structure of a highly acidic neurotoxin from scorpion Buthus tamulus at 2.2A resolution reveals novel structural features","volume":"155","author":"M Sharma","year":"2006","journal-title":"J Struct Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1074\/jbc.272.13.8320","article-title":"Makatoxin I, a novel toxin isolated from the venom of the scorpion Buthus martensi Karsch, exhibits nitrergic actions","volume":"272","author":"J Gong","year":"1997","journal-title":"J Biol Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/3669","article-title":"Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin","volume":"1","author":"RS Chuang","year":"1998","journal-title":"Nat Neurosci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-5793(03)01175-X","article-title":"Isolation of delta-missulenatoxin-Mb1a, the major vertebrate-active spider delta-toxin from the venom of Missulena bradleyi (Actinopodidae)","volume":"554","author":"SJ Gunning","year":"2003","journal-title":"FEBS Lett"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1046\/j.1471-4159.2003.01685.x","article-title":"Novel excitatory Conus peptides define a new conotoxin superfamily","volume":"85","author":"EC Jimenez","year":"2003","journal-title":"J Neurochem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"9929","DOI":"10.1021\/bi700797f","article-title":"Structure and sodium channel activity of an excitatory I1-superfamily conotoxin","volume":"46","author":"O Buczek","year":"2007","journal-title":"Biochemistry"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/BJ20051678","article-title":"Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system","volume":"395","author":"L Sanz","year":"2006","journal-title":"Biochem J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cbpb.2012.06.002","article-title":"Accelerated evolution and functional divergence of scorpion short-chain K+ channel toxins after speciation","volume":"163","author":"B Gao","year":"2012","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/oxfordjournals.molbev.a026412","article-title":"Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails","volume":"17","author":"TF Duda Jr","year":"2000","journal-title":"Mol Biol Evol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.toxicon.2011.02.001","article-title":"The tale of a resting gland: transcriptome of a replete venom gland from the scorpion Hottentotta judaicus","volume":"57","author":"D Morgenstern","year":"2011","journal-title":"Toxicon"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nchembio.441","article-title":"Messy biology and the origins of evolutionary innovations","volume":"6","author":"DS Tawfik","year":"2010","journal-title":"Nat Chem Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e65984","DOI":"10.1371\/journal.pone.0065984","article-title":"Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel","volume":"8","author":"M Rong","year":"2013","journal-title":"PLoS ONE"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jms.1389","article-title":"Venomics: unravelling the complexity of animal venoms with mass spectrometry","volume":"43","author":"P Escoubas","year":"2008","journal-title":"J Mass Spectrom"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0100682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:56:44Z","timestamp":1588971404000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0100682"}},"subtitle":[],"editor":[{"given":"Paulo L.","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":74,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0100682","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]}}}