{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:15:38Z","timestamp":1767179738100,"version":"build-2238731810"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0100870","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T13:17:27Z","timestamp":1405084647000},"page":"e100870","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Minjong","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwi Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Jin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Gwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Jun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hwan","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kook Lae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1572-0241.2006.01034.x","article-title":"Spectrum of liver histology in presumed decompensated alcoholic liver disease","volume":"102","author":"DA Elphick","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref2","first-page":"170","article-title":"Alcoholism and alcoholic liver disease: focusing on epidemiological investigation in Asia","volume":"4","author":"YM Li","year":"2005","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.hepres.2004.08.016","article-title":"Recent understanding of immunological aspects in alcoholic hepatitis","volume":"30","author":"H Saito","year":"2004","journal-title":"Hepatol Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1185\/030079905X56493","article-title":"Alcoholic hepatitis: from pathogenesis to treatment","volume":"21","author":"S Sougioultzis","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2004.050781","article-title":"Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score","volume":"54","author":"EH Forrest","year":"2005","journal-title":"Gut"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.hep.2003.09.038","article-title":"Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone","volume":"38","author":"P Mathurin","year":"2003","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM196607142750201","article-title":"Prognosis in acute liver disease of the alcoholic patient","volume":"275","author":"WG Hardison","year":"1966","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1053\/gast.1996.v110.pm8964410","article-title":"Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone","volume":"110","author":"P Mathurin","year":"1996","journal-title":"Gastroenterology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hep.20503","article-title":"MELD accurately predicts mortality in patients with alcoholic hepatitis","volume":"41","author":"W Dunn","year":"2005","journal-title":"Hepatology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1111\/j.1572-0241.2008.02104.x","article-title":"A new scoring system for prognostic stratification of patients with alcoholic hepatitis","volume":"103","author":"M Dominguez","year":"2008","journal-title":"The American journal of gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0016-5085(78)90401-8","article-title":"Corticosteroid therapy of alcoholic hepatitis","volume":"75","author":"WC Maddrey","year":"1978","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids","volume":"45","author":"A Louvet","year":"2007","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.3748\/wjg.v12.i43.6909","article-title":"Current concepts and controversies in the treatment of alcoholic hepatitis","volume":"12","author":"C Rongey","year":"2006","journal-title":"World journal of gastroenterology: WJG"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.gtc.2011.06.008","article-title":"Alcoholic hepatitis: prognostic models and treatment","volume":"40","author":"AK Singal","year":"2011","journal-title":"Gastroenterology clinics of North America"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1046\/j.1440-1746.2003.03217.x","article-title":"Pathogenesis and management of alcoholic hepatitis","volume":"18","author":"PS Haber","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/archinte.162.19.2236","article-title":"Racial and ethnic differences in alcohol-associated aspartate aminotransferase and gamma-glutamyltransferase elevation","volume":"162","author":"SH Stewart","year":"2002","journal-title":"Archives of internal medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0899-3289(00)00054-7","article-title":"Models of care in New York State Medicaid substance abuse clinics. Range of services and linkages to medical care","volume":"12","author":"C Laine","year":"2000","journal-title":"Journal of substance abuse"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jhep.2003.06.003","article-title":"Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease","volume":"41","author":"F Vidal","year":"2004","journal-title":"J Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/alcalc\/agg021","article-title":"Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area","volume":"38","author":"T Konishi","year":"2003","journal-title":"Alcohol Alcohol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00197271","article-title":"Distribution of ADH2 and ALDH2 genotypes in different populations","volume":"88","author":"HW Goedde","year":"1992","journal-title":"Hum Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1530-0277.1993.tb05673.x","article-title":"Alcohol consumption and alcoholic liver disease: evidence of a threshold level of effects of ethanol","volume":"17","author":"VT Savolainen","year":"1993","journal-title":"Alcohol Clin Exp Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/j.1572-0241.1998.00587.x","article-title":"Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology","volume":"93","author":"AJ McCullough","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1751-2980.2010.00470.x","article-title":"Diagnosis and management of alcoholic liver disease","volume":"12","author":"AJ McCullough","year":"2011","journal-title":"Journal of digestive diseases"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0169-2607(97)00043-6","article-title":"Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions","volume":"54","author":"H Heinzl","year":"1997","journal-title":"Comput Methods Programs Biomed"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/sim.4154","article-title":"On the C-statistics for evaluating overall adequacy of risk prediction procedures with censored survival data","volume":"30","author":"H Uno","year":"2011","journal-title":"Statistics in medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1541-0420.2008.00995.x","article-title":"Generalized maximally selected statistics","volume":"64","author":"T Hothorn","year":"2008","journal-title":"Biometrics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S0168-8278(13)60119-1","article-title":"Spontaneous decrease in liver injury does not strongly predict evaluation of patients with severe alcoholic hepatitis treated with corticosteroids","volume":"58","author":"FA A. Louvet","year":"2013","journal-title":"Journal of hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1053\/j.gastro.2011.02.017","article-title":"A revised model for end-stage liver disease optimizes prediction of mortality among patients awaiting liver transplantation","volume":"140","author":"MD Leise","year":"2011","journal-title":"Gastroenterology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMoa0801209","article-title":"Hyponatremia and mortality among patients on the liver-transplant waiting list","volume":"359","author":"WR Kim","year":"2008","journal-title":"The New England journal of medicine"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Forrest EH, Gleeson D (2012) Is a liver biopsy necessary in alcoholic hepatitis? J Hepatol 56: 1427\u20131428; author reply 1428\u20131429.","DOI":"10.1016\/j.jhep.2011.12.028"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0167184","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0100870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T19:42:45Z","timestamp":1649619765000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0100870"}},"subtitle":[],"editor":[{"given":"Salvatore","family":"Petta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0100870","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}