{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:46Z","timestamp":1787021926613,"version":"build-2736575974"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0101448","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T13:43:40Z","timestamp":1404308620000},"page":"e101448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Domain Specific Changes in Cognition at High Altitude and Its Correlation with Hyperhomocysteinemia"],"prefix":"10.1371","volume":"9","author":[{"given":"Vijay K.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpana B.","family":"Hota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidhu B.","family":"Mahapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Vashishtha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil K.","family":"Hota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsering","family":"Norboo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi B.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"ref1","first-page":"94","article-title":"Effect of chronic hypobaric hypoxia on components of the human event related potential","volume":"120","author":"SB Singh","year":"2004","journal-title":"Indian J Med Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/WNL.39.2.210","article-title":"Persistent cognitive impairment in climbers after repeated s q qexposure to extreme altitude","volume":"39","author":"M Regard","year":"1989","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0163-1047(05)80023-8","article-title":"Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion","volume":"62","author":"B Shukitt-Hale","year":"1994","journal-title":"Behav Neural Biol"},{"key":"ref4","first-page":"2953","article-title":"Lactate during exercise at extreme altitude","volume":"45","author":"JB West","year":"1986","journal-title":"Fed Proc"},{"key":"ref5","first-page":"678","article-title":"Effects of different stay durations on attentional performance during two mountain expeditions","volume":"71","author":"M Bonnon","year":"2000","journal-title":"Aviat Space Environ Med"},{"key":"ref6","first-page":"168","article-title":"Hyperhomocysteinemia in Alzheimer dementia patients and cognitive decline after 6 months follow-up period","volume":"19","author":"MC Tu","year":"2010","journal-title":"Acta Neurol Taiwan"},{"key":"ref7","first-page":"234","article-title":"Homocysteine Metabolism: Nutritional Modulation and Impact on Health and Disease","volume":"2","author":"AL Miller","year":"1997","journal-title":"Alternative Medicine Review"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/jcbfm.2013.1","article-title":"Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation","volume":"33","author":"TL Sudduth","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/an.112.002535","article-title":"The role of B vitamins in preventing and treating cognitive impairment and decline","volume":"3","author":"MS Morris","year":"2012","journal-title":"Adv Nutr"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Curr\u00f2 M, Gugliandolo A, Gangemi C, Risitano R, Lentile R, <etal>et al<\/etal>.. (2014) Toxic Effects of Mildly Elevated Homocysteine Concentrations in Neuronal-Like Cells. Neurochem Res [In press].","DOI":"10.1007\/s11064-014-1338-7"},{"key":"ref11","first-page":"584","article-title":"Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia Epigenetics","volume":"8","author":"M Kinoshita","year":"2013"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1212\/01.WNL.0000129986.19019.5D","article-title":"Total homocysteine and cognition in a tri-ethnic cohort, the Northern Manhattan Study","volume":"63","author":"CB Wright","year":"2004","journal-title":"Neurology"},{"key":"ref13","first-page":"321","article-title":"From mild cognitive impairment to Alzheimer&apos;s disease-influence of homocysteine, vitamin B<sub>12<\/sub> and folic acid on cognition over time, results from one-year follow-up","volume":"43","author":"J Siuda","year":"2009","journal-title":"Neurol Neurochir Pol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000126914","article-title":"Homocysteine, folic acid and cognition in a large community-based sample of elderly people-the 3C Dijon Study","volume":"30","author":"JS Vidal","year":"2008","journal-title":"Neuroepidemiology"},{"key":"ref15","unstructured":"World Health Organization, Switzerland (2008) WHO STEPS. Surveillance. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/chp\/steps\" xlink:type=\"simple\">www.who.int\/chp\/steps<\/ext-link>. Accessed 2008 Aug 12."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"AT Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"ref17","unstructured":"Roach RC, Bartsch P, Oelz O, Hackett PH, Lake Louise AMS Scoring Consensus Committee (1993) The Lake Louise acute mountain sickness scoring system. In: Sutton JR, Houston CS, Coates G, editors.Hypoxia and Molecular Biology: Burlingto: Queen City Press. pp. 272\u2013274."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1001\/archpsyc.1983.01790060110016","article-title":"The Mini-Mental State Examination","volume":"40","author":"MF Folstein","year":"1983","journal-title":"Arch Gen Psychiatry"},{"key":"ref19","first-page":"411","article-title":"Multi-Domain Cognitive Screening Test for neuropsychological assessment for cognitive decline in acclimatized low landers staying at high altitude","volume":"136","author":"SK Hota","year":"2012","journal-title":"Indian J Med Res"},{"key":"ref20","unstructured":"Raven JC, Court JH, Raven J (1992) Manual for Raven&apos;s standard progressive matrices. Oxford: Oxford Psychologists Press."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U","article-title":"Clock-drawing, is it the ideal cognitive screening test?","volume":"15","author":"KI Schulman","year":"2000","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref22","unstructured":"Bender L (1938) A visual-motor Gestalt test and its clinical use. American Orthopsychiatric Association Monograph Series Number 3. New York: American Orthopsychiatric Association."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00223980.1989.10542974","article-title":"The sensitivity of the Bender-Gestalt Test as a screening instrument for neuropsychological impairment in older adults","volume":"123","author":"RB Margolis","year":"1989","journal-title":"J Psychol"},{"key":"ref24","first-page":"9","article-title":"Learning of serial digits leads to frontal activation in functional MR imaging","volume":"12","author":"HM Karaka\u015f","year":"2006","journal-title":"Diagn Interv Radiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1037\/0033-2909.109.2.163","article-title":"Half a century of research on the Stroop effect, an integrative review","volume":"109","author":"CM MacLeod","year":"1991","journal-title":"Psycholl Bull"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1207\/S15324826AN0802_4","article-title":"The symbol trail making test, test development and utility as a measure of cognitive impairment","volume":"8","author":"SW Barncord","year":"2001","journal-title":"Appl Neuropsychol"},{"key":"ref27","unstructured":"Lezak MD (1995) Neuropsychological assessment. 3<sup>rd<\/sup> ed. New York: Oxford University Press."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.med.49.1.31","article-title":"Homocysteine and cardiovascular disease","volume":"49","author":"H Refsum","year":"1998","journal-title":"Annu Rev Med"},{"key":"ref29","first-page":"11","article-title":"Physiological responses and evaluation of effects of BMI, smoking and drinking in high altitude acclimatization: a cohort study in Chinese Han young males","volume":"8","author":"QQ Peng","year":"2013","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/ham.2009.1085","article-title":"Minimal effects on human memory following long term living at moderate altitude","volume":"12","author":"J Zhang","year":"2011","journal-title":"High Alt Med Bio"},{"key":"ref31","first-page":"993","article-title":"Cognitive performance during short acclimation to severe hypoxia","volume":"68","author":"D Leifflen","year":"1997","journal-title":"Aviat Space Environ Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s004240050671","article-title":"Cognitive performance during a simulated climb of Mount Everest, implications for brain function and central adaptive processes under chronic hypoxic stress","volume":"436","author":"JH Abraini","year":"1998","journal-title":"Pflugers Arch"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.amjmed.2005.07.062","article-title":"Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging","volume":"119","author":"N Fayed","year":"2006","journal-title":"Am J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00634375","article-title":"New evidence from magnetic resonance imaging of brain changes after climbs at extreme altitude","volume":"70","author":"E Garrido","year":"1995","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"ref35","first-page":"52","article-title":"Effect of high altitude HA on event related brain potentials","volume":"47","author":"SB Singh","year":"2003","journal-title":"Indian J Physiol Pharmacol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4149\/gpb_2011_04_389","article-title":"The effects of chronic long-term intermittent hypobaric hypoxia on blood rheology parameters","volume":"30","author":"N Yelmen","year":"2011","journal-title":"Gen Physiol Biophys"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/jramc-157-01-07","article-title":"Hematological changes at altitude","volume":"157","author":"K Wheatley","year":"2011","journal-title":"JR Army Med Corps"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1515\/CCLM.2007.356","article-title":"The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases","volume":"45","author":"R Obeid","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.atherosclerosis.2011.02.027","article-title":"Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study","volume":"216","author":"RP Kloppenborg","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/j.1468-1331.2008.02243.x","article-title":"Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areas","volume":"15","author":"M Di Paola","year":"2008","journal-title":"Eur J Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1580\/PR19-04.1","article-title":"Recurrent sagittal sinus thrombosis occurring at high altitude during expeditions to Cho Oyu","volume":"17","author":"SC Skaiaa","year":"2006","journal-title":"Wilderness Environ Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuint.2007.04.003","article-title":"Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach","volume":"51","author":"SK Hota","year":"2007","journal-title":"Neurochem Int"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0101448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T06:28:22Z","timestamp":1565591302000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0101448"}},"subtitle":[],"editor":[{"given":"Sonia","family":"Brucki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,2]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0101448","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,2]]}}}