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Beijing: Peking Medical University and Peking Union Medical College coadunation united Press. pp. 215\u2013218."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/em.20660","article-title":"Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese hamster ovary cells","volume":"52","author":"S Wang","year":"2011","journal-title":"Environ Mol Mutagen"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0891-5849(00)00408-1","article-title":"Role of glutathione S-transferases in oxidative stress induced male germ cell apoptosis","volume":"29","author":"AV Rao","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/j.1939-4640.1987.tb00973.x","article-title":"Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa","volume":"8","author":"JG Alvarez","year":"1987","journal-title":"J Androl"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1093\/humrep\/dei231","article-title":"Sperm DNA fragmentation: threshold value in male fertility","volume":"20","author":"M Sergerie","year":"2005","journal-title":"Hum Reprod"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/j.1939-4640.2002.tb02324.x","article-title":"Oxidative stress and male infertility: from research bench to clinical practice","volume":"23","author":"RA Saleh","year":"2002","journal-title":"J Androl"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.toxlet.2008.07.020","article-title":"Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice","volume":"181","author":"ST Yang","year":"2008","journal-title":"Toxicol Lett"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000076824","article-title":"Inhibition of lactate dehydrogenase C4(LDH-C4)blocks capacitation of mouse sperm in vitro","volume":"103","author":"C Duan","year":"2003","journal-title":"Cytogenet Genome Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.exger.2008.02.004","article-title":"Effects of ageing and Alzheimer&apos;s disease on mitochondrial function of human platelets","volume":"43","author":"C Shi","year":"2008","journal-title":"Exp Gerontol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0101572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T09:36:32Z","timestamp":1716975392000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0101572"}},"subtitle":[],"editor":[{"given":"David L.","family":"McCormick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,8]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0101572","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,8]]}}}