{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:38Z","timestamp":1790790818070,"version":"4.1.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0101974","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T17:21:36Z","timestamp":1405099296000},"page":"e101974","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Inhibition of Angiotensin II-Induced Cardiac Hypertrophy and Associated Ventricular Arrhythmias by a p21 Activated Kinase 1 Bioactive Peptide"],"prefix":"10.1371","volume":"9","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee K.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek A.","family":"Terrar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Solaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd2193","article-title":"Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface","volume":"6","author":"TA McKinsey","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.RES.0000111522.02730.56","article-title":"Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes","volume":"94","author":"Y Ke","year":"2004","journal-title":"Circ Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/01.RES.0000266742.51389.a4","article-title":"Regulation of L-Type Calcium Channel and Delayed Rectifier Potassium Channel Activity by p21-Activated Kinase-1 in Guinea Pig Sinoatrial Node Pacemaker Cells","volume":"100","author":"Y Ke","year":"2007","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.pbiomolbio.2009.01.007","article-title":"Regulation of cardiac excitation and contraction by p21 activated kinase-1","volume":"98","author":"Y Ke","year":"2008","journal-title":"Prog Biophys Mol Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1161\/01.RES.0000266742.51389.a4","article-title":"Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells","volume":"100","author":"Y Ke","year":"2007","journal-title":"Circ Res"},{"key":"ref6","first-page":"2702","article-title":"PAK1 is a novel signal transducer attenuating cardiac hypertrophy","volume":"2702\u201315","author":"W Liu","year":"2011","journal-title":"Circulation 124(24)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.yjmcc.2011.09.016","article-title":"Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1\/2 and inhibition of protein phosphatase 2A","volume":"51","author":"DM Taglieri","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1161\/01.CIR.98.21.2334","article-title":"Sudden Cardiac Death","volume":"98","author":"DP Zipes","year":"1998","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0008-6363(99)00023-1","article-title":"Mechanisms of remodeling of gap junction distributions and the development of anatomic substrates of arrhythmias","volume":"42","author":"JE Saffitz","year":"1999","journal-title":"Cardiovasc Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/CIRCRESAHA.108.184044","article-title":"Gap Junction Remodeling and Spironolactone-Dependent Reverse Remodeling in the Hypertrophied Heart","volume":"104","author":"J Qu","year":"2009","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/jmcc.2000.1293","article-title":"Gap Junction Remodeling in Hypertrophied Left Ventricles of Aortic-banded Rats: Prevention by Angiotensin II Type 1 Receptor Blockade","volume":"33","author":"L Emdad","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"DM Bers","year":"2008","journal-title":"Annu Rev Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ymeth.2005.05.017","article-title":"Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction","volume":"37","author":"A Beeser","year":"2005","journal-title":"Methods"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/sj.onc.1209983","article-title":"The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity","volume":"26","author":"M Thullberg","year":"2006","journal-title":"Oncogene"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1083\/jcb.201010059","article-title":"Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration","volume":"193","author":"VD Delorme-Walker","year":"2011","journal-title":"J Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1128\/MCB.17.3.1129","article-title":"Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes","volume":"17","author":"E Manser","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/sj.onc.1209983","article-title":"The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity","volume":"26","author":"M Thullberg","year":"2007","journal-title":"Oncogene"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2125.1999.00871.x","article-title":"Regression of left ventricular hypertrophy; what are appropriate therapeutic objectives?","volume":"47","author":"DJ Sheridan","year":"1999","journal-title":"Br J Clin Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvr163","article-title":"Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43","volume":"92","author":"X Ai","year":"2011","journal-title":"Cardiovasc Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI7798","article-title":"Wnt-1 regulation of connexin43 in cardiac myocytes","volume":"105","author":"Z Ai","year":"2000","journal-title":"J Clin Invest"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0101974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T18:54:03Z","timestamp":1565636043000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0101974"}},"subtitle":[],"editor":[{"given":"Sadashiva","family":"Karnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,11]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0101974","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,11]]}}}