{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T06:26:15Z","timestamp":1769322375076,"version":"3.49.0"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102085","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T19:38:32Z","timestamp":1404934712000},"page":"e102085","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genome-Wide Scan Reveals LEMD3 and WIF1 on SSC5 as the Candidates for Porcine Ear Size"],"prefix":"10.1371","volume":"9","author":[{"given":"Longchao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weizhen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kebin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuebo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"ref1","unstructured":"Zhang ZG, Li BD, Chen XH (1986) Pig Breeds in China. Shanghai: Shanghai Scientific and Technical Publisher."},{"key":"ref2","unstructured":"Rothschild MF, Ruvinsky A (1998) The Genetics of the Pig. Oxon, UK: CAB International."},{"issue":"(1)","key":"ref3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ajmg.a.34352","article-title":"Microtia: Epidemiology and genetics","volume":"158A","author":"DV Luquetti","year":"2012","journal-title":"Am J Med Genet A"},{"issue":"(4)","key":"ref4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2052.2009.01867.x","article-title":"A genome scan for quantitative trait loci affecting three ear traits in a White Duroc\u00d7Chinese Erhualian resource population","volume":"40","author":"J Ma","year":"2009","journal-title":"Anim Genet"},{"issue":"(3)","key":"ref5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1365-2052.2007.01591.x","article-title":"QTL modulating ear size and erectness in pigs","volume":"38","author":"WH Wei","year":"2007","journal-title":"Anim Genet"},{"issue":"(5)","key":"ref6","doi-asserted-by":"crossref","first-page":"e1002043","DOI":"10.1371\/journal.pgen.1002043","article-title":"A missense mutation in PPARD causes a major QTL effect on ear size in pigs","volume":"7","author":"J Ren","year":"2011","journal-title":"PLoS Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1297-9686-44-6","article-title":"Fine mapping of a QTL for ear size on porcine chromosome 5 and identification of high mobility group AT-hook 2 (HMGA2) as a positional candidate gene","volume":"44","author":"P Li","year":"2012","journal-title":"Genet Sel Evol"},{"issue":"(2)","key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrg1521","article-title":"Genome-wide association studies for common diseases and complex traits","volume":"6","author":"JN Hirschhorn","year":"2005","journal-title":"Nat Rev Genet"},{"issue":"(7)","key":"ref9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng1810","article-title":"A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep","volume":"38","author":"A Clop","year":"2006","journal-title":"Nat Genet"},{"issue":"(6960)","key":"ref10","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nature02064","article-title":"A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig","volume":"425","author":"AS Van Laere","year":"2003","journal-title":"Nature"},{"issue":"(11)","key":"ref11","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrg3069","article-title":"Understanding type 1 diabetes through genetics: advances and prospects","volume":"12","author":"C Polychronakos","year":"2011","journal-title":"Nat Rev Genet"},{"issue":"(12)","key":"ref12","doi-asserted-by":"crossref","first-page":"e28600","DOI":"10.1371\/journal.pone.0028600","article-title":"A genome-wide SNP scan reveals novel loci for egg production and quality traits in white leghorn and brown-egg dwarf layers","volume":"6","author":"W Liu","year":"2011","journal-title":"PLoS One"},{"issue":"(8)","key":"ref13","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2527\/jas.2010-3138","article-title":"A genome-wide association study of meat and carcass traits in Australian cattle","volume":"89","author":"S Bolormaa","year":"2011","journal-title":"J Anim Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2156-12-43","article-title":"Genome-wide association of milk fatty acids in Dutch dairy cattle","volume":"12","author":"AC Bouwman","year":"2011","journal-title":"BMC Genet"},{"issue":"(10)","key":"ref15","doi-asserted-by":"crossref","first-page":"e13661","DOI":"10.1371\/journal.pone.0013661","article-title":"Genome-wide association studies for milk production traits in Chinese Holstein population","volume":"5","author":"L Jiang","year":"2010","journal-title":"PLoS One"},{"issue":"(2)","key":"ref16","doi-asserted-by":"crossref","first-page":"e14726","DOI":"10.1371\/journal.pone.0014726","article-title":"Genome-wide association study identifies loci for body composition and structural soundness traits in pigs","volume":"6","author":"B Fan","year":"2011","journal-title":"PLoS One"},{"issue":"(4)","key":"ref17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.7150\/ijbs.3614","article-title":"Genome-wide association analysis of meat quality traits in a porcine Large White\u00d7Minzhu intercross population","volume":"8","author":"W Luo","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"(3)","key":"ref18","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"SA Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"issue":"(1)","key":"ref19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1534\/genetics.107.075614","article-title":"Genome-wide rapid association using mixed model and regression: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis","volume":"177","author":"YS Aulchenko","year":"2007","journal-title":"Genetics"},{"issue":"(12)","key":"ref20","doi-asserted-by":"crossref","first-page":"e1274","DOI":"10.1371\/journal.pone.0001274","article-title":"A genomic Background based method for association analysis in related individuals","volume":"2","author":"N Amin","year":"2007","journal-title":"PLoS One"},{"key":"ref21","unstructured":"Madsen P, S\u00f8rensen P, Su G, Damgaard LH, Thomsen H, et al. (2006) DMU- a package for analyzing multivariate mixed models. In 8th World Congress on Genetics Applied to Livestock Production, Brasil."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1186\/1471-2156-6-S1-S134","article-title":"Power and type I error rate of false discovery rate approaches in genome-wide association studies","volume":"6","author":"Q Yang","year":"2005","journal-title":"BMC Genetics"},{"issue":"(2)","key":"ref23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/5935","article-title":"An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs","volume":"21","author":"C Nezer","year":"1999","journal-title":"Nat Genet"},{"issue":"(1)","key":"ref24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/genetics\/165.1.277","article-title":"Haplotype sharing refines the location of an imprinted quantitative trait locus with major effect on muscle mass to a 250-kb chromosome segment containing the porcine IGF2 gene","volume":"165","author":"C Nezer","year":"2003","journal-title":"Genetics"},{"issue":"(2)","key":"ref25","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"HAPLOVIEW: analysis and visual-ization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"(2)","key":"ref26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/338688","article-title":"Score tests for association between traits and haplotypes when linkage phase is ambiguous","volume":"70","author":"DJ Schaid","year":"2002","journal-title":"AMJ Hum Genet"},{"issue":"(8)","key":"ref27","doi-asserted-by":"crossref","first-page":"e1000451","DOI":"10.1371\/journal.pbio.1000451","article-title":"A Simple Genetic Architecture Underlies Morphological Variation in Dogs","volume":"8","author":"AR Boyko","year":"2010","journal-title":"PLoS Biol"},{"issue":"(4945)","key":"ref28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.2305264","article-title":"Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant","volume":"247","author":"X Xiang","year":"1990","journal-title":"Science"},{"issue":"(10)","key":"ref29","doi-asserted-by":"crossref","first-page":"e1002316","DOI":"10.1371\/journal.pgen.1002316","article-title":"Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping","volume":"7","author":"A Vaysse","year":"2011","journal-title":"PLoS Genet"},{"issue":"(280)","key":"ref30","first-page":"ra49","article-title":"Inhibition of TGF-\u03b2 signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A","volume":"6","author":"B Bourgeois","year":"2013","journal-title":"Sci Signal"},{"issue":"(3)","key":"ref31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1359\/JBMR.0301239","article-title":"Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells","volume":"19","author":"S Zhou","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"(6726)","key":"ref32","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/18899","article-title":"A new secreted protein that binds to Wnt proteins and inhibits their activites","volume":"398","author":"JC Hsieh","year":"1999","journal-title":"Nature"},{"issue":"(1)","key":"ref33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"BT MacDonald","year":"2009","journal-title":"Dev Cell"},{"issue":"(53)","key":"ref34","doi-asserted-by":"crossref","first-page":"55958","DOI":"10.1074\/jbc.M407810200","article-title":"Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells","volume":"279","author":"Q Luo","year":"2004","journal-title":"J Biol Chem"},{"issue":"(8)","key":"ref35","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1242\/dev.076463","article-title":"Dermal \u03b2-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation","volume":"139","author":"D Chen","year":"2012","journal-title":"Development"},{"issue":"(3)","key":"ref36","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jcp.21342","article-title":"Roles of Wnt signaling in bone growth, remodeling, skeletal disorders and fracture repair","volume":"215","author":"CE Macsai","year":"2008","journal-title":"J Cell Physiol"},{"issue":"(16)","key":"ref37","doi-asserted-by":"crossref","first-page":"7317","DOI":"10.1073\/pnas.1000031107","article-title":"Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis","volume":"107","author":"L Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"(23)","key":"ref38","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1242\/dev.080358","article-title":"A dual function for canonical Wnt\/\u03b2-catenin signaling in the developing mammalian cochlea","volume":"139","author":"BE Jacques","year":"2012","journal-title":"Development"},{"issue":"(13)","key":"ref39","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1242\/dev.017905","article-title":"Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode","volume":"135","author":"CS Jayasena","year":"2008","journal-title":"Development"},{"issue":"(6)","key":"ref40","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ejmg.2009.08.005","article-title":"2.3 Mb terminal deletion in 12p13.33 associated with oculoauriculovertebral spectrum and evaluation of WNT5B as a candidate gene","volume":"52","author":"C Rooryck","year":"2009","journal-title":"Eur J Med Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T12:56:04Z","timestamp":1716987364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102085"}},"subtitle":[],"editor":[{"given":"Junwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,9]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102085","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,9]]}}}