{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:35:11Z","timestamp":1773308111895,"version":"3.50.1"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102307","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T18:54:27Z","timestamp":1405623267000},"page":"e102307","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Limitation of Number of Strains and Persistence of False Positive Loci in QTL Mapping Using Recombinant Inbred Strains"],"prefix":"10.1371","volume":"9","author":[{"given":"Lishi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaifen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weikuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1058889","article-title":"In silico mapping of complex disease-related traits in mice","volume":"292","author":"A Grupe","year":"2001","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.294.5551.2423a","article-title":"In silico mapping of mouse quantitative trait loci","volume":"294","author":"EJ Chesler","year":"2001","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.294.5551.2423a","article-title":"In silico mapping of mouse quantitative trait loci","volume":"294","author":"A Darvasi","year":"2001","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1000331","DOI":"10.1371\/journal.pgen.1000331","article-title":"Mouse genome-wide association mapping needs linkage analysis to avoid false-positive Loci","volume":"5","author":"G Manenti","year":"2009","journal-title":"PLoS Genet"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Ioannidis JP (2005) Why most published research findings are false. PLoS Med 2(8): e124. Epub 2005 Aug 30.","DOI":"10.1371\/journal.pmed.0020124"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1371\/journal.pmed.0040168","article-title":"Why most published research findings are false: problems in the analysis","volume":"4(4)","author":"S Goodman","year":"2007","journal-title":"PLoS Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg1206","article-title":"Complex Trait Consortium. The nature and identification of quantitative trait loci: a community&apos;s view","volume":"4","author":"O Abiola","year":"2003","journal-title":"Nat Rev Genet"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, <etal>et al<\/etal>.. (2005) Uncovering regulatory pathways that affect hematopoietic stem cell function using &apos;genetical genomics&apos;. Nat Genet 37: 225\u2013232. Epub 2005 Feb 13.","DOI":"10.1038\/ng1497"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.cell.2012.08.012","article-title":"Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits","volume":"150","author":"PA Andreux","year":"2012","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/gbb.12029","article-title":"High-precision genetic mapping of behavioral traits in the diversity outbred mouse population","volume":"12(4)","author":"RW Logan","year":"2013","journal-title":"Genes Brain Behav"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1101\/gr.113886.110","article-title":"Genetic analysis in the Collaborative Cross breeding population","volume":"21(8)","author":"VM Philip","year":"2011","journal-title":"Genome Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1128\/JVI.00514-09","article-title":"Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice","volume":"83","author":"AC Boon","year":"2009","journal-title":"Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2202-10-44","article-title":"The genetic control of neocortex volume and covariation with neocortical gene expression in mice","volume":"10","author":"SM Gaglani","year":"2009","journal-title":"BMC Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e18405","DOI":"10.1371\/journal.pone.0018405","article-title":"Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation","volume":"6","author":"P Porcu","year":"2011","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1601-183X.2009.00540.x","article-title":"High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains","volume":"9","author":"VM Philip","year":"2010","journal-title":"Genes Brain Behav"},{"key":"ref16","first-page":"1351","article-title":"KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice","volume":"79(6)","author":"J Ryan","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1152\/physiolgenomics.00056.2006","article-title":"Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains","volume":"26(3)","author":"M Buresova","year":"2006","journal-title":"Physiol Genomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1385\/NI:1:4:299","article-title":"WebQTL: Web-based complex trait analysis","volume":"1","author":"J Wang","year":"2003","journal-title":"Neuroinformatics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4238\/2013.September.18.1","article-title":"Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective","volume":"12","author":"Y Huang","year":"2013","journal-title":"Genet Mol Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/j.1530-0277.2002.tb02463.x","article-title":"Genetic dissection of quantitative trait loci specifying sedative\/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines","volume":"26","author":"B Bennett","year":"2002","journal-title":"Alcohol Clin Exp Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T23:09:46Z","timestamp":1565651386000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102307"}},"subtitle":[],"editor":[{"given":"Chunyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102307","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]}}}