{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:46Z","timestamp":1787021926959,"version":"build-2736575974"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102382","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T14:01:27Z","timestamp":1407247287000},"page":"e102382","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Serum miRNA Signature in Moyamoya Disease"],"prefix":"10.1371","volume":"9","author":[{"given":"Dongwei","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"E20","DOI":"10.3171\/2011.3.FOCUS1151","article-title":"Moyamoya disease: a review of histopathology, biochemistry, and genetics","volume":"30","author":"DG Weinberg","year":"2011","journal-title":"Neurosurg Focus"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1474-4422(08)70240-0","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"S Kuroda","year":"2008","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/cns.12130","article-title":"Impaired dynamic cerebral autoregulation in moyamoya disease","volume":"19","author":"J Chen","year":"2013","journal-title":"CNS NeurosciTher"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s00234-013-1291-1","article-title":"Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease","volume":"55","author":"DW Dai","year":"2013","journal-title":"Neuroradiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e68986","DOI":"10.1371\/journal.pone.0068986","article-title":"Hemodynamic segmentation of brain perfusion images with delay and dispersion effects using an expectation-maximization algorithm","volume":"8","author":"CF Lu","year":"2013","journal-title":"PLoS One"},{"key":"ref6","first-page":"1836","article-title":"&quot;Ivy sign&quot; on fluid-attenuated inversion-recovery images in childhood moyamoya disease","volume":"20","author":"M Maeda","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3174\/ajnr.A1504","article-title":"The leptomeningeal &quot;ivy sign&quot; on fluid-attenuated inversion recovery MR imaging in Moyamoya disease: a sign of decreased cerebral vascular reserve","volume":"30","author":"N Mori","year":"2009","journal-title":"Am J Neuroradiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/ene.12202","article-title":"High resolution MRI difference between moyamoya disease and intracranial atherosclerosis","volume":"20","author":"YJ Kim","year":"2013","journal-title":"Eur J Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/RLI.0b013e3182981137","article-title":"Effect of Delayed Transit Time on Arterial Spin Labeling: Correlation With Dynamic Susceptibility Contrast Perfusion Magnetic Resonance in Moyamoya Disease","volume":"48","author":"TJ Yun","year":"2013","journal-title":"Invest Radiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/STROKEAHA.111.621300","article-title":"Moyamoya disease in China: its clinical features and outcomes","volume":"43","author":"L Duan","year":"2012","journal-title":"Stroke"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000333424","article-title":"Paediatric moyamoya in mainland France: a comprehensive survey of academic neuropaediatric centres","volume":"33","author":"M Kossorotoff","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1159\/000319893","article-title":"Association of a functional polymorphism in the MMP-3 gene with Moyamoya Disease in the Chinese Han population","volume":"30","author":"H Li","year":"2010","journal-title":"Cerebrovasc Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s10038-004-0143-6","article-title":"A novel susceptibility locus for moyamoya disease on chromosome 8q23","volume":"49","author":"K Sakurai","year":"2004","journal-title":"J Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1161\/01.STR.31.4.930","article-title":"Linkage of familial moyamoya disease (spontaneous occlusion of the circle of Willis) to chromosome 17q25","volume":"31","author":"T Yamauchi","year":"2000","journal-title":"Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajhg.2009.04.007","article-title":"Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and moyamoya disease, along with thoracic aortic disease","volume":"84","author":"DC Guo","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s12199-009-0116-7","article-title":"A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians","volume":"15","author":"W Liu","year":"2010","journal-title":"Environ Health Prevent Med"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, et al. (2010) Polymorphisms in TGFB1 and PDGFRB are associated with Moyamoya disease in European patients. Acta Neurochir: 1\u20138.","DOI":"10.1007\/s00701-010-0711-9"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e48179","DOI":"10.1371\/journal.pone.0048179","article-title":"Molecular analysis of RNF213 gene for moyamoya disease in the Chinese Han population","volume":"7","author":"Z Wu","year":"2012","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbrc.2013.07.004","article-title":"Downregulation of Securin by the variant RNF213 R4810K (rs112735431, G&gt;A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients","volume":"438","author":"T Hitomi","year":"2013","journal-title":"BiochemBiophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.gene.2013.05.083","article-title":"Impacts and interactions of PDGFRB, MMP-3, TIMP-2, and RNF213 polymorphisms on the risk of Moyamoya disease in Han Chinese human subjects","volume":"526","author":"X Wang","year":"2013","journal-title":"Gene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"F Kamada","year":"2010","journal-title":"J Hum Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"W Liu","year":"2011","journal-title":"Plos ONE"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1016\/S1470-2045(12)70073-6","article-title":"microRNAs in cancer management","volume":"13","author":"YW Kong","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2008.07.085","article-title":"hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells","volume":"1236","author":"L Shi","year":"2008","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-011-0679-1","article-title":"MicroRNAs involved in the EGFR\/PTEN\/AKT pathway in gliomas","volume":"106","author":"Y Wang","year":"2012","journal-title":"J Neurooncol"},{"key":"ref26","first-page":"213","article-title":"Upregulation of microRNA-100 predicts poor prognosis in patients with pediatric acute myeloid leukemia","volume":"5","author":"J Bai","year":"2012","journal-title":"Onco Targets Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1073\/pnas.1100048108","article-title":"MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer","volume":"108","author":"M Boeri","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1476-4598-9-306","article-title":"Serum microRNAs as non-invasive biomarkers for cancer","volume":"9","author":"JC Brase","year":"2010","journal-title":"Mol Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e23925","DOI":"10.1371\/journal.pone.0023925","article-title":"Early second-trimester serum miRNA profiling predicts gestational diabetes mellitus","volume":"6","author":"C Zhao","year":"2011","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/1471-2407-13-478","article-title":"Decreased miR-106a inhibits glioma cell glucose uptake and proliferation by targeting SLC2A3 in GBM","volume":"13","author":"DW Dai","year":"2013","journal-title":"BMC Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1593\/tlo.09256","article-title":"Circulating miR-210 as a Novel Hypoxia Marker in Pancreatic Cancer","volume":"3","author":"AS Ho","year":"2010","journal-title":"Transl Oncol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1158\/1940-6207.CAPR-09-0094","article-title":"MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease","volume":"2","author":"J Wang","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1161\/STROKEAHA.107.513408","article-title":"Moyamoya disease in Europeans","volume":"39","author":"M Kraemer","year":"2008","journal-title":"Stroke"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/eurheartj\/ehq013","article-title":"Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans","volume":"31","author":"GK Wang","year":"2010","journal-title":"Eur Heart J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"PS Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ymeth.2010.01.032","article-title":"Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR),","volume":"50","author":"EM Kroh","year":"2010","journal-title":"Methods"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-62703-107-3_17","article-title":"Molecular network analysis of diseases and drugs in KEGG","volume":"939","author":"M Kanehisa","year":"2013","journal-title":"Methods Mol Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkr988","article-title":"KEGG for integration and interpretation of large-scale molecular datasets","volume":"40","author":"M Kanehisa","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3892\/ol.2012.609","article-title":"Regulation of let-7 and its target oncogenes (Review)","volume":"3","author":"X Wang","year":"2012","journal-title":"Oncol Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/PPO.0b013e318258b60a","article-title":"The microRNA-17-92 family of microRNA clusters in development and disease","volume":"18","author":"CP Concepcion","year":"2012","journal-title":"Cancer J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/cdd.2009.69","article-title":"miR-15a and miR-16-1 in cancer: discovery, function and future perspectives","volume":"17","author":"RI Aqeilan","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1159\/000258197","article-title":"MiR-106b and MiR-15b modulate apoptosis and angiogenesis in myocardial infarction","volume":"29","author":"Z Liu","year":"2012","journal-title":"Cell Physiol Biochem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/CS20100043","article-title":"Gene expression profiling in whole blood of patients with coronary artery disease","volume":"119","author":"C Taurino","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/ajh.2011.116","article-title":"MicroRNA-130a mediates proliferation of vascular smooth muscle cells in hypertension","volume":"24","author":"WH Wu","year":"2011","journal-title":"Am J Hypertens"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/bjc.2012.330","article-title":"Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer","volume":"107","author":"T Sasahira","year":"2012","journal-title":"Br J Cancer"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1097\/HJH.0b013e32833a4922","article-title":"MicroRNA-125a\/b-5p inhibits endothelin-1 expression in vascular endothelial cells","volume":"28","author":"D Li","year":"2010","journal-title":"J Hypertens"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jnnp.2009.191817","article-title":"Plasma matrix metalloproteinases, cytokines and angiogenic factors in moyamoya disease","volume":"81","author":"HS Kang","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"W Liu","year":"2011","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first Moyamoya disease gene","volume":"56","author":"F Kamada","year":"2011","journal-title":"J Hum Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1212\/WNL.0b013e318249f71f","article-title":"Homozygous c.14576G&gt;A variant of RNF213 predicts early-onset and severe form of moyamoya disease","volume":"78","author":"S Miyatake","year":"2012","journal-title":"Neurology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.ajhg.2011.04.017","article-title":"Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya","volume":"88","author":"S Miskinyte","year":"2011","journal-title":"Am J Hum Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.exphem.2010.10.004","article-title":"Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature","volume":"38","author":"N Scholer","year":"2010","journal-title":"Exp Hematol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"811","DOI":"10.7150\/ijbs.4439","article-title":"Human circulating microRNA-1 and microRNA-126 as potential novel indicators for acute myocardial infarction","volume":"8","author":"G Long","year":"2012","journal-title":"Int J Biol Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e40169","DOI":"10.1371\/journal.pone.0040169","article-title":"Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF","volume":"7","author":"Q Bi","year":"2012","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"N Kosaka","year":"2010","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"J Skog","year":"2008","journal-title":"Nat Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T11:50:28Z","timestamp":1565697028000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102382"}},"subtitle":[],"editor":[{"given":"Balraj","family":"Mittal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102382","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}