{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T14:02:37Z","timestamp":1792936957464,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102503","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T14:08:14Z","timestamp":1405346894000},"page":"e102503","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Radial Scars and Subsequent Breast Cancer Risk: A Meta-Analysis"],"prefix":"10.1371","volume":"9","author":[{"given":"Mengmeng","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanliang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1056\/NEJM198501173120303","article-title":"Risk factors for breast cancer in women with proliferative breast disease","volume":"312","author":"WD Dupont","year":"1985","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJMoa044383","article-title":"Benign breast disease and the risk of breast cancer","volume":"353","author":"LC Hartmann","year":"2005","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1524-4741.2007.00388.x","article-title":"Breast cancer incidence in a cohort of women with benign breast disease from a multiethnic, primary health care population","volume":"13","author":"MJ Worsham","year":"2007","journal-title":"Breast J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10549-008-0198-8","article-title":"Risk factors for breast cancer from benign breast disease in a diverse population","volume":"118","author":"MJ Worsham","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/00000478-200306000-00017","article-title":"Benign breast disease and breast cancer risk: morphology and beyond","volume":"27","author":"SJ Schnitt","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10549-013-2535-9","article-title":"Radial scars and subsequent breast cancer risk: results from the Nurses\u2019 Health Studies","volume":"139","author":"SA Aroner","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"ref7","unstructured":"Linell F, Ljungberg O, Andersson I (1980) Breast carcinoma. Aspects of early stages, progression and related problems. Acta Pathol Microbiol Scand Suppl: 1\u2013233."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0002-9610(00)00506-7","article-title":"A better understanding of the term radial scar","volume":"180","author":"TA King","year":"2000","journal-title":"Am J Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0046-8177(84)80083-0","article-title":"Subgross pathologic features and incidence of radial scars in the breast","volume":"15","author":"SR Wellings","year":"1984","journal-title":"Hum Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1365-2559.1997.d01-600.x","article-title":"Pathology of R4 spiculated lesions in the breast screening programme","volume":"30","author":"AG Douglas-Jones","year":"1997","journal-title":"Histopathology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1148\/radiology.195.3.7753984","article-title":"Mammographic lesions suggestive of radial scars: microscopic findings in 40 cases","volume":"195","author":"C Frouge","year":"1995","journal-title":"Radiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2559.1993.tb01194.x","article-title":"Carcinoma and atypical hyperplasia in radial scars and complex sclerosing lesions: importance of lesion size and patient age","volume":"23","author":"JP Sloane","year":"1993","journal-title":"Histopathology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/ajcp\/71.3.240","article-title":"A non-encapsulated sclerosing lesion of the breast","volume":"71","author":"ER Fisher","year":"1979","journal-title":"Am J Clin Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10549-007-9569-9","article-title":"Risk of neoplastic transformation in asymptomatic radial scar. Analysis of 117 cases","volume":"107","author":"E Manfrin","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2559.1985.tb02446.x","article-title":"An autopsy study of radial scar in the female breast","volume":"9","author":"M Nielsen","year":"1985","journal-title":"Histopathology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/1097-0142(19870301)59:5<1019::AID-CNCR2820590528>3.0.CO;2-N","article-title":"Radial scars in women with breast cancer","volume":"59","author":"M Nielsen","year":"1987","journal-title":"Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1056\/NEJM199902113400604","article-title":"Radial scars in benign breast-biopsy specimens and the risk of breast cancer","volume":"340","author":"TW Jacobs","year":"1999","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2214\/ajr.174.4.1741075","article-title":"Role of sonography in evaluation of radial scars of the breast","volume":"174","author":"MA Cohen","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0720-048X(92)90196-G","article-title":"Radial scars detected mammographically in a breast cancer screening programme","volume":"15","author":"E Azavedo","year":"1992","journal-title":"Eur J Radiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ejso.2005.04.004","article-title":"All radial scars\/complex sclerosing lesions seen on breast screening mammograms should be excised","volume":"31","author":"T Fasih","year":"2005","journal-title":"Eur J Surg Oncol"},{"key":"ref21","unstructured":"Ottawa Hospital Research Institute Website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\" xlink:type=\"simple\">http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp<\/ext-link>."},{"key":"ref22","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"N Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"CB Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00000478-200204000-00003","article-title":"Histopathologic types of benign breast lesions and the risk of breast cancer: case-control study","volume":"26","author":"AM Shaaban","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/cncr.21730","article-title":"Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies","volume":"106","author":"ME Sanders","year":"2006","journal-title":"Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10549-007-9605-9","article-title":"Breast cancer risk in women with radial scars in benign breast biopsies","volume":"108","author":"JC Berg","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10552-010-9508-7","article-title":"A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer","volume":"21","author":"GC Kabat","year":"2010","journal-title":"Cancer Causes Control"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/hupa.2002.30190","article-title":"Radial scars of the breast and breast carcinomas have similar alterations in expression of factors involved in vascular stroma formation","volume":"33","author":"TW Jacobs","year":"2002","journal-title":"Hum Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/hupa.2002.125375","article-title":"Molecular and genetic abnormalities in radial scar","volume":"33","author":"M Iqbal","year":"2002","journal-title":"Hum Pathol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ejso.2004.08.004","article-title":"Radial scar, complex sclerosing lesion and risk of breast cancer. Analysis of 175 cases in Northern Ireland","volume":"30","author":"JA Patterson","year":"2004","journal-title":"Eur J Surg Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ejso.2011.04.011","article-title":"Long term follow-up and risk of breast cancer after a radial scar or complex sclerosing lesion has been identified in a benign open breast biopsy","volume":"37","author":"DM Bunting","year":"2011","journal-title":"Eur J Surg Oncol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T21:01:11Z","timestamp":1540328471000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102503"}},"subtitle":[],"editor":[{"given":"Annie N. Y.","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,14]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102503","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,14]]}}}