{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:21:23Z","timestamp":1790814083642,"version":"4.1.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T00:00:00Z","timestamp":1405900800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102603","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T05:50:34Z","timestamp":1406008234000},"page":"e102603","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Characterization of Subtle Brain Abnormalities in a Mouse Model of Hedgehog Pathway Antagonist-Induced Cleft Lip and Palate"],"prefix":"10.1371","volume":"9","author":[{"given":"Robert J.","family":"Lipinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter T.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shonagh K.","family":"O'Leary-Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob J.","family":"Ament","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Pecevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary P.","family":"Cofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Budin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Everson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Allan","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen K.","family":"Sulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/01.smj.0000209093.78617.3a","article-title":"The multidisciplinary evaluation and management of cleft lip and palate","volume":"99","author":"NH Robin","year":"2006","journal-title":"South Med J"},{"key":"ref2","unstructured":"Waitzman N, Scheffler RM, Romano PS (1996) The cost of birth defects: estimates of the value of prevention. Lanham, Md.: University Press of America. xiv, 262 p."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1597\/1545-1569(1999)036<0001:PIICCS>2.3.CO;2","article-title":"Psychological issues in craniofacial care: state of the art","volume":"36","author":"MC Endriga","year":"1999","journal-title":"Cleft Palate Craniofac J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1601-6343.2007.00394.x","article-title":"A developmental approach to mental health for children and adolescents with orofacial clefts","volume":"10","author":"BR Collett","year":"2007","journal-title":"Orthod Craniofac Res"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Conrad AL, Richman L, Nopoulos P, Dailey S (2009) Neuropsychological Functioning in Children with Non-Syndromic Cleft of the Lip and\/or Palate. Child Neuropsychol: 1\u201314.","DOI":"10.1080\/09297040802691120"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/jpepsy\/jsp047","article-title":"Reading in children with orofacial clefts versus controls","volume":"35","author":"BR Collett","year":"2010","journal-title":"J Pediatr Psychol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1016\/S0028-3932(02)00043-X","article-title":"Cognitive dysfunction in adult males with non-syndromic clefts of the lip and\/or palate","volume":"40","author":"P Nopoulos","year":"2002","journal-title":"Neuropsychologia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1542\/peds.97.4.529","article-title":"Cognition, communication, and hearing in young children with cleft lip and palate and in control children: a longitudinal study","volume":"97","author":"LJ Jocelyn","year":"1996","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Wehby GL, Collet B, Barron S, Romitti PA, Ansley TN, <etal>et al<\/etal>.. (2014) Academic Achievement of Children and Adolescents With Oral Clefts. Pediatrics.","DOI":"10.1542\/peds.2013-3072"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1044\/jshr.2302.447","article-title":"Cognitive patterns and learning disabilities of cleft palate children with verbal deficits","volume":"23","author":"LC Richman","year":"1980","journal-title":"J Speech Hear Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1597\/1545-1569(1998)035<0127:LDSAAG>2.3.CO;2","article-title":"Learning disability, school achievement, and grade retention among children with cleft: a two-center study","volume":"35","author":"HL Broder","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"ref12","first-page":"21","article-title":"Reading disability in children with clefts","volume":"25","author":"LC Richman","year":"1988","journal-title":"Cleft Palate J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1597\/1545-1569(2003)040<0154:DTRDOC>2.0.CO;2","article-title":"Do the reading disabilities of children with cleft fit into current models of developmental dyslexia?","volume":"40","author":"LC Richman","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"ref14","first-page":"763","article-title":"Relationships among intelligence, speech proficiency, and hearing sensitivity in children with cleft palates","volume":"7","author":"RE Estes","year":"1970","journal-title":"Cleft Palate J"},{"key":"ref15","first-page":"7","article-title":"Effects of recurrent middle ear effusion in preschool years on language and learning","volume":"3","author":"RJ Sak","year":"1982","journal-title":"J Dev Behav Pediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00125817-200201000-00001","article-title":"Structural brain abnormalities in adult males with clefts of the lip and\/or palate","volume":"4","author":"P Nopoulos","year":"2002","journal-title":"Genet Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archpedi.161.8.753","article-title":"Abnormal brain structure in children with isolated clefts of the lip or palate","volume":"161","author":"P Nopoulos","year":"2007","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1469-7580.2009.01084.x","article-title":"Three-dimensional morphometric analysis of brain shape in nonsyndromic orofacial clefting","volume":"214","author":"SM Weinberg","year":"2009","journal-title":"J Anat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/00016359509005963","article-title":"Human prenatal craniofacial development related to brain development under normal and pathologic conditions","volume":"53","author":"I Kjaer","year":"1995","journal-title":"Acta Odontol Scand"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/dvg.20710","article-title":"Mechanisms that underlie co-variation of the brain and face","volume":"49","author":"RS Marcucio","year":"2011","journal-title":"Genesis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ydbio.2005.04.030","article-title":"Molecular interactions coordinating the development of the forebrain and face","volume":"284","author":"RS Marcucio","year":"2005","journal-title":"Dev Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1242\/dev.026583","article-title":"A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm","volume":"136","author":"D Hu","year":"2009","journal-title":"Development"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/383407a0","article-title":"Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function","volume":"383","author":"C Chiang","year":"1996","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ajmg.c.30247","article-title":"Holoprosencephaly and holoprosencephaly-like phenotypes: Review of facial and molecular findings in patients from a craniofacial hospital in Brazil","volume":"154C","author":"A Richieri-Costa","year":"2010","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/8.13.2479","article-title":"The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly","volume":"8","author":"L Nanni","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/jmedgenet-2012-101008","article-title":"Genotypic and phenotypic analysis of 396 individuals with mutations in Sonic Hedgehog","volume":"49","author":"BD Solomon","year":"2012","journal-title":"J Med Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/bdra.20656","article-title":"Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications","volume":"88","author":"RJ Lipinski","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/toxsci\/kfn076","article-title":"Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse","volume":"104","author":"RJ Lipinski","year":"2008","journal-title":"Toxicol Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e43067","DOI":"10.1371\/journal.pone.0043067","article-title":"Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent","volume":"7","author":"RJ Lipinski","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neuroimage.2007.05.013","article-title":"High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology","volume":"37","author":"GA Johnson","year":"2007","journal-title":"Neuroimage"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1530-0277.2009.00921.x","article-title":"Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8","volume":"33","author":"SE Parnell","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"ref32","first-page":"7962251","article-title":"Automatic Skull-stripping of Rat MRI\/DTI Scans and Atlas Building","volume":"7962","author":"I Oguz","year":"2011","journal-title":"Proceedings - Society of Photo-Optical Instrumentation Engineers"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neuroimage.2011.03.031","article-title":"Microscopic diffusion tensor atlas of the mouse brain","volume":"56","author":"Y Jiang","year":"2011","journal-title":"Neuroimage"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ajmg.c.30238","article-title":"Neuroimaging Advances in Holoprosencephaly: Refining the Spectrum of the Midline Malformation","volume":"154C","author":"JS Hahn","year":"2010","journal-title":"American Journal of Medical Genetics Part C-Seminars in Medical Genetics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/bdra.20295","article-title":"Holoprosencephaly: Clinical, anatomic, and molecular dimensions","volume":"76","author":"MM Cohen","year":"2006","journal-title":"Birth Defects Research Part a-Clinical and Molecular Teratology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ajmg.a.36333","article-title":"Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse","volume":"164","author":"A Aerts","year":"2014","journal-title":"Am J Med Genet A"},{"key":"ref37","first-page":"840","article-title":"Olfactory deficits in boys with cleft palate","volume":"82","author":"RA Richman","year":"1988","journal-title":"Pediatrics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0022-3476(78)81141-X","article-title":"Prevalence of growth hormone deficiency in children with cleft lip or palate","volume":"93","author":"D Rudman","year":"1978","journal-title":"J Pediatr"},{"key":"ref39","first-page":"576","article-title":"Pituitary growth hormone insufficiency associated with cleft lip and palate. An embryonal developmental defect","volume":"24","author":"Z Laron","year":"1969","journal-title":"Helv Paediatr Acta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1136\/adc.53.12.952","article-title":"Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate","volume":"53","author":"A Roitman","year":"1978","journal-title":"Arch Dis Child"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/pr.2012.12","article-title":"Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and\/or palate","volume":"71","author":"E van der Plas","year":"2012","journal-title":"Pediatric Research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1597\/1545-1569(2000)037<0441:ABMIPW>2.0.CO;2","article-title":"Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysis","volume":"37","author":"P Nopoulos","year":"2000","journal-title":"Cleft Palate Craniofac J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1552-6569.2001.tb00072.x","article-title":"Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and\/or palate","volume":"11","author":"P Nopoulos","year":"2001","journal-title":"J Neuroimaging"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e928","DOI":"10.1542\/peds.2005-1788","article-title":"Third ventricle enlargement among newborn infants with trisomy 21","volume":"117","author":"MS Schimmel","year":"2006","journal-title":"Pediatrics"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Muller M, Esser R, Kotter K, Voss J, Muller A, <etal>et al<\/etal>.. (2013) Third ventricular enlargement in early stages of multiple sclerosis is a predictor of motor and neuropsychological deficits: a cross-sectional study. BMJ Open 3.","DOI":"10.1136\/bmjopen-2013-003582"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12663-010-0058-z","article-title":"Ophthalmic considerations in cleft lip and palate patients","volume":"10","author":"S Anchlia","year":"2011","journal-title":"J Maxillofac Oral Surg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/154405910608500210","article-title":"Origin of the deciduous upper lateral incisor and its clinical aspects","volume":"85","author":"M Hovorakova","year":"2006","journal-title":"J Dent Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1597\/1545-1569(1998)035<0154:DPOPAP>2.3.CO;2","article-title":"Distribution patterns of primary and permanent dentition in children with unilateral complete cleft lip and palate","volume":"35","author":"TP Tsai","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000337543","article-title":"Hedgehog signalling in development of the secondary palate","volume":"16","author":"MT Cobourne","year":"2012","journal-title":"Front Oral Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1601-6343.2009.01462.x","article-title":"Face shape of unaffected parents with cleft affected offspring: combining three-dimensional surface imaging and geometric morphometrics","volume":"12","author":"SM Weinberg","year":"2009","journal-title":"Orthod Craniofac Res"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0106607","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T00:00:00Z","timestamp":1408924800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T23:42:26Z","timestamp":1717112546000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102603"}},"subtitle":[],"editor":[{"given":"Jingwu","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,21]]},"references-count":50,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102603","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0106607","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,21]]}}}