{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:54:48Z","timestamp":1778770488409,"version":"3.51.4"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T00:00:00Z","timestamp":1406073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102737","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T22:02:30Z","timestamp":1406152950000},"page":"e102737","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Role of Dystrophin in Airway Smooth Muscle Phenotype, Contraction and Lung Function"],"prefix":"10.1371","volume":"9","author":[{"given":"Pawan","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujata","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald L.","family":"Stelmack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Halayko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","article-title":"Dystrophin: the protein product of the Duchenne muscular dystrophy locus","volume":"51","author":"EP Hoffman","year":"1987","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1474-4422(03)00585-4","article-title":"Dystrophin and mutations: one gene, several proteins, multiple phenotypes","volume":"2","author":"F Muntoni","year":"2003","journal-title":"Lancet neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/01.RES.0000126574.61061.25","article-title":"The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma","volume":"94","author":"KA Lapidos","year":"2004","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbadis.2006.05.010","article-title":"Dystrophin, its interactions with other proteins, and implications for muscular dystrophy","volume":"1772","author":"JM Ervasti","year":"2007","journal-title":"Biochimica et biophysica acta"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.120.5.1159","article-title":"Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle","volume":"120","author":"AJ North","year":"1993","journal-title":"J Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1139\/y05-107","article-title":"The association of caveolae, actin, and the dystrophin-glycoprotein complex: a role in smooth muscle phenotype and function?","volume":"83","author":"AJ Halayko","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"L57","DOI":"10.1152\/ajplung.00378.2007","article-title":"Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation","volume":"294","author":"P Sharma","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0959-437X(91)80033-I","article-title":"Duchenne muscular dystrophy","volume":"1","author":"JS Chamberlain","year":"1991","journal-title":"Current opinion in genetics & development"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0140-6736(90)91364-G","article-title":"Dystrophin function","volume":"335","author":"AE Emery","year":"1990","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Mokri B, Engel AG (1998) Duchenne dystrophy: electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber. 1975. Neurology 51: 1 and 10 pages following.","DOI":"10.1212\/WNL.51.1.1-a"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archneur.1976.00500050001001","article-title":"Pathogenesis of muscular dystrophies","volume":"33","author":"LP Rowland","year":"1976","journal-title":"Archives of neurology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/WNL.28.7.670","article-title":"Studies of sarcolemmal integrity in myopathic muscle","volume":"28","author":"WG Bradley","year":"1978","journal-title":"Neurology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00019052-199704000-00016","article-title":"Muscular dystrophies and the dystrophin-glycoprotein complex","volume":"10","author":"V Straub","year":"1997","journal-title":"Curr Opin Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJM198807073190103","article-title":"Gastric hypomotility in Duchenne\u2019s muscular dystrophy","volume":"319","author":"RJ Barohn","year":"1988","journal-title":"N Engl J Med"},{"key":"ref15","first-page":"742","article-title":"Symptoms of upper gastrointestinal dysfunction in Duchenne muscular dystrophy: case-control study","volume":"71","author":"KM Jaffe","year":"1990","journal-title":"Arch Phys Med Rehabil"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1073\/pnas.81.4.1189","article-title":"X chromosome-linked muscular dystrophy (mdx) in the mouse","volume":"81","author":"G Bulfield","year":"1984","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.2662404","article-title":"The molecular basis of muscular dystrophy in the mdx mouse: a point mutation","volume":"244","author":"P Sicinski","year":"1989","journal-title":"Science"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0022-510X(94)00276-T","article-title":"mdx mice show progressive weakness and muscle deterioration with age","volume":"129","author":"C Pastoret","year":"1995","journal-title":"Journal of the neurological sciences"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/mus.880181011","article-title":"Age-related differences in regeneration of dystrophic (mdx) and normal muscle in the mouse","volume":"18","author":"C Pastoret","year":"1995","journal-title":"Muscle & nerve"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1469-7793.2001.00591.x","article-title":"Force and power output of fast and slow skeletal muscles from mdx mice 6\u201328 months old","volume":"535","author":"GS Lynch","year":"2001","journal-title":"The Journal of physiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2990.1988.tb00890.x","article-title":"The mdx mouse skeletal muscle myopathy: II. Contractile properties","volume":"14","author":"GR Coulton","year":"1988","journal-title":"Neuropathology and applied neurobiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mus.880070903","article-title":"Muscle development in mdx mutant mice","volume":"7","author":"J Dangain","year":"1984","journal-title":"Muscle & nerve"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/334154a0","article-title":"The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs","volume":"334","author":"BJ Cooper","year":"1988","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ajmg.1320420320","article-title":"Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy: a review","volume":"42","author":"BA Valentine","year":"1992","journal-title":"American journal of medical genetics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/apmr.2002.35109","article-title":"Eccentric contraction injury in dystrophic canine muscle","volume":"83","author":"MK Childers","year":"2002","journal-title":"Archives of physical medicine and rehabilitation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/mus.20298","article-title":"Skinned single fibers from normal and dystrophin-deficient dogs incur comparable stretch-induced force deficits","volume":"31","author":"MK Childers","year":"2005","journal-title":"Muscle & nerve"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-61737-982-6_7","article-title":"Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements","volume":"709","author":"JN Kornegay","year":"2011","journal-title":"Methods in molecular biology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/mus.880111008","article-title":"Muscular dystrophy in a litter of golden retriever dogs","volume":"11","author":"JN Kornegay","year":"1988","journal-title":"Muscle & nerve"},{"key":"ref29","first-page":"909","article-title":"Feline muscular dystrophy with dystrophin deficiency","volume":"135","author":"JL Carpenter","year":"1989","journal-title":"The American journal of pathology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/oxfordjournals.bmb.a072353","article-title":"Animal models of Duchenne and Becker muscular dystrophy","volume":"45","author":"BJ Cooper","year":"1989","journal-title":"British medical bulletin"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/oxfordjournals.jhered.a110543","article-title":"Canine muscular dystrophy: confirmation of X-linked inheritance","volume":"79","author":"BJ Cooper","year":"1988","journal-title":"The Journal of heredity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0960-8966(94)90082-5","article-title":"Deletion of the dystrophin muscle promoter in feline muscular dystrophy","volume":"4","author":"NJ Winand","year":"1994","journal-title":"Neuromuscular disorders: NMD"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00003677-200304000-00004","article-title":"Lateral force transmission across costameres in skeletal muscle","volume":"31","author":"RJ Bloch","year":"2003","journal-title":"Exercise and sport sciences reviews"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"13591","DOI":"10.1074\/jbc.R200021200","article-title":"Costameres: the Achilles\u2019 heel of Herculean muscle","volume":"278","author":"JM Ervasti","year":"2003","journal-title":"The Journal of biological chemistry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)80533-4","article-title":"Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy","volume":"90","author":"RM Grady","year":"1997","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1023\/A:1005364713451","article-title":"Rapid recovery following contraction-induced injury to in situ skeletal muscles in mdx mice","volume":"19","author":"SV Brooks","year":"1998","journal-title":"Journal of muscle research and cell motility"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1023\/A:1014587918367","article-title":"Tibialis anterior muscles in mdx mice are highly susceptible to contraction-induced injury","volume":"22","author":"C Dellorusso","year":"2001","journal-title":"Journal of muscle research and cell motility"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1440-1681.2007.04865.x","article-title":"Diaphragm muscle strip preparation for evaluation of gene therapies in mdx mice","volume":"35","author":"JA Faulkner","year":"2008","journal-title":"Clinical and experimental pharmacology & physiology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/BF00121296","article-title":"Increased susceptibility of EDL muscles from mdx mice to damage induced by contractions with stretch","volume":"14","author":"P Moens","year":"1993","journal-title":"Journal of muscle research and cell motility"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1073\/pnas.90.8.3710","article-title":"Dystrophin protects the sarcolemma from stresses developed during muscle contraction","volume":"90","author":"BJ Petrof","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/jcpa.2001.0526","article-title":"Muscle lesions associated with dystrophin deficiency in neonatal golden retriever puppies","volume":"126","author":"F Nguyen","year":"2002","journal-title":"Journal of comparative pathology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.nmd.2008.06.386","article-title":"Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone","volume":"18","author":"T Turgeman","year":"2008","journal-title":"Neuromuscular disorders: NMD"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"H1550","DOI":"10.1152\/ajpheart.01253.2007","article-title":"Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone","volume":"294","author":"KD Huebner","year":"2008","journal-title":"American journal of physiology Heart and circulatory physiology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1164\/ajrccm.160.6.9903131","article-title":"Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle","volume":"160","author":"ET Naureckas","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"ref45","first-page":"L197","article-title":"Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes","volume":"276","author":"AJ Halayko","year":"1999","journal-title":"Am J Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1242\/jcs.066712","article-title":"beta-Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release","volume":"123","author":"P Sharma","year":"2010","journal-title":"J Cell Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"L1406","DOI":"10.1152\/ajplung.00312.2007","article-title":"Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle","volume":"293","author":"R Gosens","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"L1091","DOI":"10.1152\/ajplung.2000.278.5.L1091","article-title":"Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes","volume":"278","author":"RW Mitchell","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"G Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Sharma P, Ryu MH, Basu S, Maltby SA, Yeganeh B, <etal>et al<\/etal>.. (2012) Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase. British Journal of Pharmacology.","DOI":"10.1111\/j.1476-5381.2012.02014.x"},{"key":"ref51","first-page":"A5294","article-title":"The Dystrophin Glycoprotein Complex (DGC) Regulates Spatial Organization And Function Of Caveolae In Human Airway Smooth Muscle Cells","volume":"181","author":"P Sharma","year":"2010","journal-title":"Am J of Respir Crit Care Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/intimm\/dxq476","article-title":"ICOS ligand expression is essential for allergic airway hyperresponsiveness","volume":"23","author":"K Kadkhoda","year":"2011","journal-title":"Int Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1165\/rcmb.2012-0060OC","article-title":"Sustained suppression of IL-13 by a vaccine attenuates airway inflammation and remodeling in mice","volume":"48","author":"Y Ma","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"McGovern TK, Robichaud A, Fereydoonzad L, Schuessler TF, Martin JG (2013) Evaluation of respiratory system mechanics in mice using the forced oscillation technique. J Vis Exp: e50172.","DOI":"10.3791\/50172"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1139\/y04-128","article-title":"Distribution of phenotypically disparate myocyte subpopulations in airway smooth muscle","volume":"83","author":"AJ Halayko","year":"2005","journal-title":"Can J Physiol Pharmacol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1165\/rcmb.2003-0272OC","article-title":"Phophatidylinositol-3 kinase\/mammalian target of rapamycin\/p70S6K regulates contractile protein accumulation in airway myocyte differentiation","volume":"31","author":"AJ Halayko","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1165\/rcmb.2007-0165OC","article-title":"Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes","volume":"37","author":"T Tran","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1152\/jappl.2001.90.1.358","article-title":"Molecular mechanisms of phenotypic plasticity in smooth muscle cells","volume":"90","author":"AJ Halayko","year":"2001","journal-title":"J Appl Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","article-title":"Regulation of differentiation of vascular smooth muscle cells","volume":"75","author":"GK Owens","year":"1995","journal-title":"Physiol Rev"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1165\/rcmb.2004-0411OC","article-title":"4E-binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy","volume":"33","author":"L Zhou","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"L1226","DOI":"10.1152\/ajplung.2000.279.6.L1226","article-title":"Caveolae from canine airway smooth muscle contain the necessary components for a role in Ca(2+) handling","volume":"279","author":"PJ Darby","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1083\/jcb.120.5.1147","article-title":"Calcium pump of the plasma membrane is localized in caveolae","volume":"120","author":"T Fujimoto","year":"1993","journal-title":"J Cell Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1083\/jcb.119.6.1507","article-title":"Localization of inositol 1,4,5-trisphosphate receptor-like protein in plasmalemmal caveolae","volume":"119","author":"T Fujimoto","year":"1992","journal-title":"The Journal of cell biology"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Gosens R, Stelmack GL, Bos ST, Dueck G, Mutawe MM, <etal>et al<\/etal>.. (2010) Caveolin-1 is Required for Contractile Phenotype Expression by Airway Smooth Muscle Cells. J Cell Mol Med.","DOI":"10.1111\/j.1582-4934.2010.01246.x"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"L1118","DOI":"10.1152\/ajplung.00136.2007","article-title":"Caveolins and intracellular calcium regulation in human airway smooth muscle","volume":"293","author":"YS Prakash","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/physrev.1984.64.2.455","article-title":"Structural apparatus for force transmission in smooth muscles","volume":"64","author":"G Gabella","year":"1984","journal-title":"Physiol Rev"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/280328a0","article-title":"Inhomogeneous distribution of filipin-sterol complexes in smooth-muscle cell plasma-membrane","volume":"280","author":"R Montesano","year":"1979","journal-title":"Nature"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/j.1460-2075.1985.tb02315.x","article-title":"Geometry of actin-membrane attachments in the smooth muscle cell: the localisations of vinculin and alpha-actinin","volume":"4","author":"JV Small","year":"1985","journal-title":"EMBO J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-201X.1998.00441.x","article-title":"The cytoskeleton of the vertebrate smooth muscle cell","volume":"164","author":"JV Small","year":"1998","journal-title":"Acta Physiologica Scandinavica"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1101-1014","article-title":"Akt\/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo","volume":"3","author":"SC Bodine","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/ncb1101-1009","article-title":"Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K\/Akt\/mTOR and PI(3)K\/Akt\/GSK3 pathways","volume":"3","author":"C Rommel","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/mus.24151","article-title":"Exercise increases utrophin protein expression in the mdx mouse model of Duchenne muscular dystrophy","volume":"49","author":"BS Gordon","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/S0960-8966(02)00087-1","article-title":"The role of utrophin in the potential therapy of Duchenne muscular dystrophy","volume":"12","author":"KJ Perkins","year":"2002","journal-title":"Neuromuscul Disord"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/4033","article-title":"Expression of full-length utrophin prevents muscular dystrophy in mdx mice","volume":"4","author":"J Tinsley","year":"1998","journal-title":"Nat Med"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.122.4.809","article-title":"A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin","volume":"122","author":"JM Ervasti","year":"1993","journal-title":"J Cell Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1152\/japplphysiol.00118.2007","article-title":"Altered biomechanical properties of carotid arteries in two mouse models of muscular dystrophy","volume":"103","author":"WW Dye","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref77","first-page":"929","article-title":"Mechanical properties of smooth muscle portal vein in normal and dystrophin-deficient (mdx) mice","volume":"84","author":"R Mancinelli","year":"1999","journal-title":"Exp Physiol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1093\/hmg\/ddl151","article-title":"Smooth muscle-specific dystrophin expression improves aberrant vasoregulation in mdx mice","volume":"15","author":"K Ito","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"21287","DOI":"10.1074\/jbc.M311124200","article-title":"Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes","volume":"279","author":"JL Morel","year":"2004","journal-title":"J Biol Chem"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1172\/JCI11642","article-title":"Prevention of cardiomyopathy in mouse models lacking the smooth muscle sarcoglycan-sarcospan complex","volume":"107","author":"RD Cohn","year":"2001","journal-title":"J Clin Invest"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1476-5381.2012.02014.x","article-title":"Epithelium-dependent modulation of responsiveness of airways from caveolin-1 knockout mice is mediated through cyclooxygenase-2 and 5-lipoxygenase","volume":"167","author":"P Sharma","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1152\/jappl.1989.67.3.1294","article-title":"Muscarinic receptor reserve and beta-adrenergic sensitivity in tracheal smooth muscle","volume":"67","author":"SJ Gunst","year":"1989","journal-title":"J Appl Physiol (1985)"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0014-2999(88)90331-7","article-title":"Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists","volume":"156","author":"H Meurs","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1113\/jphysiol.1988.sp017279","article-title":"Contractile properties of skeletal muscles from young, adult and aged mice","volume":"404","author":"SV Brooks","year":"1988","journal-title":"The Journal of physiology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1042\/cs0840145","article-title":"Progressive deterioration of muscles in mdx mice induced by overload","volume":"84","author":"J Dick","year":"1993","journal-title":"Clinical science"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1006812004945","article-title":"The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy","volume":"179","author":"BJ Petrof","year":"1998","journal-title":"Molecular and cellular biochemistry"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0022-510X(90)90005-8","article-title":"Dystrophin-deficient mdx muscle fibers are preferentially vulnerable to necrosis induced by experimental lengthening contractions","volume":"100","author":"B Weller","year":"1990","journal-title":"Journal of the neurological sciences"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1096\/fj.01-0030fje","article-title":"Dystrophin-deficient cardiomyocytes are abnormally vulnerable to mechanical stress-induced contractile failure and injury","volume":"15","author":"G Danialou","year":"2001","journal-title":"The FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nature03844","article-title":"Dystrophic heart failure blocked by membrane sealant poloxamer","volume":"436","author":"S Yasuda","year":"2005","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T04:40:35Z","timestamp":1649738435000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102737"}},"subtitle":[],"editor":[{"given":"Diego","family":"Fraidenraich","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,23]]},"references-count":89,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102737","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,23]]}}}