{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:40:01Z","timestamp":1774528801875,"version":"3.50.1"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0102739","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T18:59:36Z","timestamp":1405623576000},"page":"e102739","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Mouse Model of Otitis Media Identifies HB-EGF as a Mediator of Inflammation-Induced Mucosal Proliferation"],"prefix":"10.1371","volume":"9","author":[{"given":"Keigo","family":"Suzukawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Tomlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwa","family":"Kurabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen I.","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen F.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"G2","DOI":"10.1016\/j.vaccine.2008.11.005","article-title":"The burden of otitis media","volume":"26","author":"MM Rovers","year":"2008","journal-title":"Vaccine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/INF.0b013e318154b24a","article-title":"The challenge of recalcitrant acute otitis media: pathogens, resistance, and treatment strategy","volume":"26","author":"E Leibovitz","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0196-0709(98)90079-5","article-title":"Bone conduction impairment in uncomplicated chronic suppurative otitis media","volume":"19","author":"Y El-Sayed","year":"1998","journal-title":"Am J Otolaryngol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0140-6736(98)05295-7","article-title":"Early surgery compared with watchful waiting for glue ear and effect on language development in preschool children: a randomised trial","volume":"353","author":"R Maw","year":"1999","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/adc.85.2.91","article-title":"Behaviour and developmental effects of otitis media with effusion into the teens","volume":"85","author":"KE Bennett","year":"2001","journal-title":"Arch Dis Child"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Wright CG, Meyerhoff WL (1994) Pathology of otitis media. Ann Otol Rhinol Laryngol Suppl 163: 24\u201326.","DOI":"10.1177\/00034894941030S507"},{"key":"ref7","unstructured":"World Health Organization (2004) Chronic suppurative otitis media: burden of illness and management options. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/pbd\/publications\/Chronicsuppurativeotitis_media.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/pbd\/publications\/Chronicsuppurativeotitis_media.pdf<\/ext-link>."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1177\/000348947108000611","article-title":"Ultrastructural pathology of the middle ear mucosa in serous otitis media","volume":"80","author":"DJ Lim","year":"1971","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/000348947708600212","article-title":"Goblet cell population in the pathological middle ear and eustachian tube of children and adults","volume":"86","author":"M Tos","year":"1977","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref10","unstructured":"Schuknecht HF (1993) Pathology of the ear. 2nd ed, Philadelphia: Lea &amp; Febiger. xv, 672."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00003086-199008000-00038","article-title":"Fibroblast growth factor. Chemical structure and biologic function","volume":"257","author":"D Gospodarowicz","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/oxfordjournals.bmb.a072333","article-title":"Fibroblast growth factors","volume":"45","author":"A Baird","year":"1989","journal-title":"Br Med Bull"},{"key":"ref13","first-page":"239","article-title":"The fibroblast growth factor family","volume":"3","author":"A Baird","year":"1991","journal-title":"Cancer Cells"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.bi.58.070189.003043","article-title":"The heparin-binding (fibroblast) growth factor family of proteins","volume":"58","author":"WH Burgess","year":"1989","journal-title":"Annu Rev Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/00016489309135769","article-title":"Growth factors during proliferation of the middle ear mucosa","volume":"113","author":"AF Ryan","year":"1993","journal-title":"Acta Otolaryngol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1288\/00005537-199403000-00018","article-title":"Acidic and basic FGF mRNA expression in the middle ear mucosa during experimental acute and chronic otitis media","volume":"104","author":"HA Koutnouyan","year":"1994","journal-title":"Laryngoscope"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3109\/00016488609108632","article-title":"Culture and characterization of rat middle-ear epithelium","volume":"101","author":"CA van Blitterswijk","year":"1986","journal-title":"Acta Otolaryngol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/00005537-200105000-00022","article-title":"Growth factors influence growth and differentiation of the middle ear mucosa","volume":"111","author":"SD Palacios","year":"2001","journal-title":"Laryngoscope"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2006.02.004","article-title":"Mouse models of induced otitis media","volume":"1091","author":"AF Ryan","year":"2006","journal-title":"Brain Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2009.02.047","article-title":"Mouse models for human otitis media","volume":"Res1277","author":"DR Trune","year":"2009","journal-title":"Brain"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1128\/IAI.01656-06","article-title":"Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media","volume":"75","author":"M Furukawa","year":"2007","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1034\/j.1600-0463.2003.1111012.x","article-title":"A mouse model for acute otitis media","volume":"111","author":"A Melhus","year":"2003","journal-title":"APMIS"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jaci.2005.07.026","article-title":"Role of mast cells in otitis media","volume":"116","author":"J Ebmeyer","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"W627","DOI":"10.1093\/nar\/gki443","article-title":"VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data","volume":"33","author":"A Hsiao","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1128\/IAI.01656-06","article-title":"Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media","volume":"75","author":"M Furukawa","year":"2007","journal-title":"Infect Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e61394","DOI":"10.1371\/journal.pone.0061394","article-title":"Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection","volume":"8","author":"A Kurabi","year":"2013","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1086\/593213","article-title":"Myeloid differentiation primary response gene 88 is required for the resolution of otitis media","volume":"198","author":"M Hernandez","year":"2008","journal-title":"J Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.0901167","article-title":"CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF\u2212\/\u2212 mice","volume":"184","author":"A Leichtle","year":"2010","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/exer.1994.1152","article-title":"Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility and differentiation of human corneal epithelial cells","volume":"59","author":"SE Wilson","year":"1994","journal-title":"Exp Eye Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1210\/en.2010-0319","article-title":"Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts","volume":"151","author":"J Shao","year":"2010","journal-title":"Endocrinology"},{"key":"ref31","first-page":"2119","article-title":"Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members","volume":"13","author":"S Morita","year":"2007","journal-title":"Mol Vis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1365-2036.2000.014s1183.x","article-title":"Effect of activin on cell growth in primary cultures of guinea pig gastric epithelial cells","volume":"14","author":"S Ogihara","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/jid.2008.366","article-title":"Macrophage inhibitory cytokine-1: a new player in melanoma development","volume":"129","author":"T Yamashita","year":"2009","journal-title":"J Invest Dermatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1634\/stemcells.21-1-5","article-title":"The unsolved enigmas of leukemia inhibitory factor","volume":"21","author":"D Metcalf","year":"2003","journal-title":"Stem Cells"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1523-1747.2002.01725.x","article-title":"The role of chemokines in melanoma tumor growth and metastasis","volume":"118","author":"AS Payne","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1091\/mbc.1.11.811","article-title":"Isolation and characterization of a macrophage-derived heparin-binding growth factor","volume":"1","author":"G Besner","year":"1990","journal-title":"Cell Regul"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1840698","article-title":"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF","volume":"251","author":"S Higashiyama","year":"1991","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1050-1738(01)00065-2","article-title":"Erbb4 and its isoforms: selective regulation of growth factor responses by naturally occurring receptor variants","volume":"10","author":"TT Junttila","year":"2000","journal-title":"Trends Cardiovasc Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1161\/01.ATV.15.10.1680","article-title":"Increased mitogenic response to heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells of diabetic rats","volume":"15","author":"K Fukuda","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1073\/pnas.91.8.2890","article-title":"T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells","volume":"91","author":"S Blotnick","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"18330","DOI":"10.1016\/S0021-9258(17)46848-7","article-title":"Heparin-binding epidermal growth factor-like growth factor expression in cultured fetal human vascular smooth muscle cells. Induction of mRNA levels and secretion of active mitogen","volume":"268","author":"SM Dluz","year":"1993","journal-title":"J Biol Chem"},{"key":"ref42","first-page":"F179","article-title":"Heparin-binding EGF-like growth factor","volume":"1333","author":"G Raab","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/1523-1747.ep12327214","article-title":"Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients","volume":"106","author":"DW McCarthy","year":"1996","journal-title":"J Invest Dermatol"},{"key":"ref44","first-page":"1584","article-title":"Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy","volume":"22","author":"S Kiso","year":"1995","journal-title":"Hepatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1172\/JCI118087","article-title":"Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury","volume":"96","author":"T Homma","year":"1995","journal-title":"J Clin Invest"},{"key":"ref46","first-page":"784","article-title":"Eosinophils expressing heparin-binding EGF-like growth factor mRNA localize around lung microvessels in pulmonary hypertension","volume":"143","author":"PP Powell","year":"1993","journal-title":"Am J Pathol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1073\/pnas.90.9.3889","article-title":"Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury","volume":"90","author":"M Marikovsky","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/jbc.M308537200","article-title":"Activation of syndecan-1 ectodomain shedding by Staphylococcus aureus alpha-toxin and beta-toxin","volume":"279","author":"PW Park","year":"2004","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H (2002) Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp 248: 171\u2013176; discussion 176\u2013180, 277\u2013282.","DOI":"10.1002\/0470860790.ch11"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1086\/379047","article-title":"Infection of U937 monocytic cells with Chlamydia pneumoniae induces extensive changes in host cell gene expression","volume":"188","author":"D Virok","year":"2003","journal-title":"J Infect Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1462-5822.2004.00366.x","article-title":"Helicobacter pylori gamma-glutamyltranspeptidase upregulates COX-2 and EGF-related peptide expression in human gastric cells","volume":"6","author":"I Busiello","year":"2004","journal-title":"Cell Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jhep.2008.06.031","article-title":"HB-EGF is a paracrine growth stimulator for early tumor prestages in inflammation-associated hepatocarcinogenesis","volume":"49","author":"S Sagmeister","year":"2008","journal-title":"J Hepatol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1462-5822.2011.01603.x","article-title":"Neisseria gonorrhoeae-induced transactivation of EGFR enhances gonococcal invasion","volume":"13","author":"KV Swanson","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1016\/S0021-9258(17)32127-0","article-title":"Heparin-binding epidermal growth factor-like growth factor is an autocrine growth factor for human keratinocytes","volume":"269","author":"K Hashimoto","year":"1994","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood-2004-09-3645","article-title":"HB-EGF\/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation","volume":"106","author":"M Krampera","year":"2005","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1083\/jcb.109.6.2741","article-title":"Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo","volume":"109","author":"WH Lai","year":"1989","journal-title":"J Cell Biol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/emboj\/20.13.3342","article-title":"N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration","volume":"20","author":"E Nishi","year":"2001","journal-title":"EMBO J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1083\/jcb.200303017","article-title":"Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF","volume":"163","author":"D Nanba","year":"2003","journal-title":"J Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"30127","DOI":"10.1074\/jbc.M010237200","article-title":"BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation","volume":"276","author":"J Lin","year":"2001","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1128\/IAI.68.7.4024-4031.2000","article-title":"Expression of cytokine genes during pneumococcal and nontypeable Haemophilus influenzae acute otitis media in the rat","volume":"68","author":"M Melhus","year":"2000","journal-title":"Infect Immun"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1095\/biolreprod.104.038539","article-title":"Role of neutrophils in matrix metalloproteinase activity in the preimplantation mouse uterus","volume":"73","author":"E Daimon","year":"2005","journal-title":"Biol Reprod"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.brainres.2006.02.004","article-title":"Mouse models of induced otitis media","volume":"1091","author":"AF Ryan","year":"2006","journal-title":"Brain Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.tripleo.2010.06.022","article-title":"Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus","volume":"110","author":"K Kumagai","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1182\/blood.V94.9.3169","article-title":"Granulocyte-macrophage colony-stimulating factor induces expression of heparin-binding epidermal growth factor-like growth factor\/diphtheria toxin receptor and sensitivity to diphtheria toxin in human neutrophils","volume":"94","author":"F Vinante","year":"1999","journal-title":"Blood"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"17255","DOI":"10.1074\/jbc.M211835200","article-title":"The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades","volume":"278","author":"H Takenobu","year":"2003","journal-title":"J Biol Chem"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e27720","DOI":"10.1371\/journal.pone.0027720","article-title":"LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling","volume":"6","author":"HW Lue","year":"2011","journal-title":"PLoS One"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e34944","DOI":"10.1371\/journal.pone.0034944","article-title":"Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene","volume":"7","author":"C Tian","year":"2012","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"22799","DOI":"10.1074\/jbc.M111.337378","article-title":"Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway","volume":"287","author":"J Lee","year":"2012","journal-title":"J Biol Chem"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1164\/rccm.201210-1843CI","article-title":"Chronic bronchitis and chronic obstructive pulmonary disease","volume":"187","author":"V Kim","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11882-007-0073-4","article-title":"Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps","volume":"7","author":"R Pawankar","year":"2007","journal-title":"Curr Allergy Asthma Rep"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0102739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T12:24:36Z","timestamp":1649679876000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0102739"}},"subtitle":[],"editor":[{"given":"Nades","family":"Palaniyar","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":70,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2014,7,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0102739","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]}}}